Biological Material Analysis
Biological Material Analysis - Related Videos
11:38
Volume Segmentation and Analysis of Biological Materials Using SuRVoS (Super-region Volume Segmentation) Workbench
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Cited by 10 •
2017
Segmentation of three-dimensional data from many imaging techniques is a major bottleneck in analysis of complex biological systems. Here, we describe the use of SuRVoS Workbench to semi-automatically segment volumetric data at various length-scales using example datasets from cryo-electron tomography, cryo soft X-ray tomography, and phase contrast X-ray tomography techniques.
11:57
Measuring Spatially- and Directionally-varying Light Scattering from Biological Material
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Cited by 5 •
2013
We present a non-destructive method for sampling spatial variation in the direction of light scattered from structurally complex materials. By keeping the material intact, we preserve gross-scale scattering behavior, while concurrently capturing fine-scale directional contributions with high-resolution imaging. Results are visualized in software at biologically-relevant positions and scales.
10:28
Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
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Cited by 5 •
2017
This paper presents a series of protocols for developing engineered cells and functionalized surfaces that enable synthetically engineered E. coli to control and manipulate programmable material surfaces.
11:32
Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering
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Cited by 14 •
2010
Methods for preparing an injectable matrix gel from decellularized tissue and injecting it into rat myocardium in vivo are described.
14:11
Quantification of Hydrogen Concentrations in Surface and Interface Layers and Bulk Materials through Depth Profiling with Nuclear Reaction Analysis
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Cited by 21 •
2016
We illustrate the application of 1H(15N,αγ)12C resonant nuclear reaction analysis (NRA) to quantitatively evaluate the density of hydrogen atoms on the surface, in the volume, and at an interfacial layer of solid materials. The near-surface hydrogen depth profiling of a Pd(110) single crystal and of SiO2/Si(100) stacks is described.
FAQs
The analysis links measurable parameters to how a sample behaves under defined conditions. Elasticity and viscoelasticity describe responses to force, while diffusion, surface structure, and molecular organization characterize transport and arrangement. Interpreting these quantities together helps explain how cells, tissues, biomolecules, or biomaterials respond to their environments and how those responses change during development, injury, or treatment.
Each approach emphasizes a different aspect of the sample. Microscopy examines structure and surface features, spectroscopy probes responses associated with molecular organization, mechanical testing evaluates elasticity and viscoelasticity, and transport analysis addresses diffusion. Combining these approaches provides complementary evidence rather than relying on a single measurement to represent the material’s complete physical behavior.
Controlled conditions make measurements comparable and help connect an observed response to a defined physical influence, such as light, force, heat, or an electromagnetic field. Without this control, changes in composition, structure, or behavior may be difficult to interpret. Consistent conditions therefore support quantitative comparisons among samples, developmental states, injuries, or treatments.
A study generally begins by selecting a biological sample and identifying the physical property or response of interest. Researchers then choose an appropriate measurement, expose the sample to controlled interactions such as force or light, and quantify the resulting structural, mechanical, molecular, or transport behavior. The measured parameters are finally related to biological function or material performance.
It is useful when researchers need to connect material behavior with biological performance. In biomechanics, measurements of elasticity, viscoelasticity, and response to force can support studies of tissues and cells. In biomaterials research, structural, surface, molecular, and transport measurements can inform material design and evaluation, including work related to medical-device development.
Quantitative measurements can reveal changes in biological materials associated with injury, treatment, or other altered states. Comparing physical parameters such as surface structure, molecular organization, diffusion, or mechanical response helps identify how the material differs from a reference condition. These results provide a physics-based way to investigate biological change without reducing the analysis to composition alone.