Irreversibility

Irreversibility is the condition in which a change or sequence cannot be mentally or physically returned to its starting state; in psychology, the term commonly describes a limitation in reasoning about reversible transformations. In Piagetian developmental theory, young children may focus on an object’s altered appearance and fail to represent the operations that produced the change, so they cannot mentally undo it to recognize conservation of quantity, number, or volume. Studying irreversibility helps researchers assess the development of logical and representational thought, distinguish perceptual judgments from operational reasoning, and explain how children gradually acquire more flexible problem-solving strategies.

Irreversibility - Related Videos

Research

JoVE EoE - Pancreatic Cancer

Irreversible Electroporation: A Technique for Ablating Pancreatic Tumor in Mouse

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2023

This video describes the procedure for performing irreversible electroporation (IRE) for non-thermal ablation of pancreatic tumors in mice. Both subcutaneous (SQ) and orthotopic tumors can be successfully treated with IRE in a highly controlled setting, facilitating various studies post-procedure.

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

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Cited by 47 •

2014

The murine model of irreversible unilateral ureteric obstruction (UUO) is presented together with the model of reversible UUO in which the ureteric obstruction is relieved by anastomosis of the severed ureter into the bladder. These models enable the study of renal inflammation and scarring as well as tissue remodeling.

Education

JoVE Core - Physics

Reversible and Irreversible Processes

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2023

The thermodynamic processes can be classified into reversible and irreversible processes. The processes that can be restored to their initial state are called reversible processes. It is only possible if the process is in quasi-static equilibrium, i.e., it takes place in infinitesimally small steps, and the system remains at equilibrium However, these are ideal processes and do not occur naturally. An ideal system undergoing a reversible process is always in thermodynamic equilibrium within...

Research

JoVE Journal - Biochemistry
Free Sample

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay

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2025

The quantitative irreversible tethering (qIT) assay is a fluorescence-based method of identifying covalent fragments that selectively engage with a target protein. Here, a detailed protocol is outlined to describe the qIT assay, with example results included.

Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer

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Cited by 17 •

2015

The use of the masseteric nerve as donor nerve represents a single-stage alternative to the criterion standard two-stage procedure of cross-facial nerve grafting and free muscle transfer in facial paralysis. We provide a detailed description to safely perform this technique with a gracilis muscle transfer and discuss indications and limitations.

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