Nikolaus Plesnila

Institute for Stroke and Dementia Research (ISD), University of Munich Medical Center

Affiliated withUniversity of Munich Medical Center University Hospital Munich Munich Cluster for Systems Neurology (SyNergy)

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 39	2013
Publication title Cited by 102	2014
Publication title	2025

Other Publications

Article	Year
Measurement of absolute values of hemoglobin oxygenation in the brain of small rodents by near infrared reflection spectrophotometry. Journal of neuroscience methods\| PubMed ID: 11856562	2002
Function of BID -- a molecule of the bcl-2 family -- in ischemic cell death in the brain. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes\| PubMed ID: 11867899	2002
Release of excitatory amino acids in the penumbra of a focal cortical necrosis. Journal of neurotrauma\| PubMed ID: 11990352	2002
Nitric oxide in the penumbra of a focal cortical necrosis in rats. Neuroscience letters\| PubMed ID: 12009523	2002
Lipid-sugar particles for intracranial drug delivery: safety and biocompatibility. Brain research\| PubMed ID: 12137923	2002
Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12415117	2002
Neuroprotection in transient focal cerebral ischemia by combination drug therapy and mild hypothermia: comparison with customary therapeutic regimen. Stroke; a journal of cerebral circulation\| PubMed ID: 12730554	2003
Relative cerebral blood flow during the secondary expansion of a cortical lesion in rats. Neuroscience letters\| PubMed ID: 12821177	2003
Combination drug therapy and mild hypothermia after transient focal cerebral ischemia in rats. Stroke; a journal of cerebral circulation\| PubMed ID: 12893947	2003
Effect of decompression craniotomy on increase of contusion volume and functional outcome after controlled cortical impact in mice. Journal of neurotrauma\| PubMed ID: 14748979	2003
Combination therapy in ischemic stroke: synergistic neuroprotective effects of memantine and clenbuterol. Stroke; a journal of cerebral circulation\| PubMed ID: 15060319	2004
Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 15087715	2004
Leukocyte-endothelium interactions during permanent focal cerebral ischemia in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 15181374	2004
Identification of brain tissue necrosis by MRI: validation by histomorphometry. Journal of neurotrauma\| PubMed ID: 15253801	2004
Role of arginine vasopressin V1 and V2 receptors for brain damage after transient focal cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 15744246	2005
Release of bradykinin and expression of kinin B2 receptors in the brain: role for cell death and brain edema formation after focal cerebral ischemia in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 15815587	2005
Motoneuron survival after C7 nerve root avulsion and replantation in the adult rabbit: effects of local ciliary neurotrophic factor and brain-derived neurotrophic factor application. Plastic and reconstructive surgery\| PubMed ID: 15923853	2005
Cluster analysis: a useful tool for the analysis of cerebral laser-Doppler scanning data. Journal of neuroscience methods\| PubMed ID: 15935225	2005
Platelet adhesion via glycoprotein IIb integrin is critical for atheroprogression and focal cerebral ischemia: an in vivo study in mice lacking glycoprotein IIb. Circulation\| PubMed ID: 16103235	2005
Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16267234	2005
Hypertonic fluid resuscitation from subarachnoid hemorrhage in rats: a comparison between small volume resuscitation and mannitol. Journal of the neurological sciences\| PubMed ID: 16343544	2006
Arterial hypotension triggers perifocal depolarizations and aggravates secondary damage in focal brain injury. Brain research\| PubMed ID: 16412395	2006
Simultaneous bilateral laser Doppler fluxmetry and electrophysiological recording during middle cerebral artery occlusion in rats. Journal of neuroscience methods\| PubMed ID: 16439028	2006
Lactacidosis-induced glial cell swelling depends on extracellular Ca2+. Neuroscience letters\| PubMed ID: 16469448	2006
Influence of the duration of ischemia and reperfusion on infarct volume and microvascular damage in mice. Neurological research\| PubMed ID: 16551441	2006
Therapeutic window of bradykinin B2 receptor inhibition after focal cerebral ischemia in rats. Neurochemistry international\| PubMed ID: 16624448	2006
An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16769887	2006
Effect of early and delayed decompressive craniectomy on secondary brain damage after controlled cortical impact in mice. Journal of neurotrauma\| PubMed ID: 16866621	2006
Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16891420	2006
Non-invasive intraoperative monitoring of blood pressure and arterial pCO2 during surgical anesthesia in mice. Journal of neuroscience methods\| PubMed ID: 16945419	2007
Bone marrow stromal cells mediate protection through stimulation of PI3-K/Akt and MAPK signaling in neurons. Neurochemistry international\| PubMed ID: 17050038	2007
Effect of oxidative stress on glial cell volume. Journal of neurotrauma\| PubMed ID: 17115914	2006
Characterization of microvascular basal lamina damage and blood-brain barrier dysfunction following subarachnoid hemorrhage in rats. Brain research\| PubMed ID: 17303089	2007
Decompression craniectomy after traumatic brain injury: recent experimental results. Progress in brain research\| PubMed ID: 17618993	2007
Aldolase C-positive cerebellar Purkinje cells are resistant to delayed death after cerebral trauma and AMPA-mediated excitotoxicity. The European journal of neuroscience\| PubMed ID: 17686042	2007
Enantio-selective effects of clenbuterol in cultured neurons and astrocytes, and in a mouse model of cerebral ischemia. European journal of pharmacology\| PubMed ID: 17869242	2007
Complex level alterations of the 2f (1)-f (2) distortion product due to hypoxia in the guinea pig. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery\| PubMed ID: 18389267	2008
Role of cortical spreading depressions for secondary brain damage after traumatic brain injury in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 18414497	2008
Egr-1 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke. The American journal of pathology\| PubMed ID: 18556777	2008
Changes of cerebral blood flow during the secondary expansion of a cortical contusion assessed by 14C-iodoantipyrine autoradiography in mice using a non-invasive protocol. Journal of neurotrauma\| PubMed ID: 18627253	2008
Expression and functional role of potassium-chloride cotransporters (KCC) in astrocytes and C6 glioma cells. Neuroscience letters\| PubMed ID: 18638521	2008
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell metabolism\| PubMed ID: 18762024	2008
Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury. The American journal of pathology\| PubMed ID: 18988795	2008
Role of vasopressin V(1a) and V2 receptors for the development of secondary brain damage after traumatic brain injury in mice. Journal of neurotrauma\| PubMed ID: 19118456	2008
Effects of transient focal cerebral ischemia in mice deficient in puma. Neuroscience letters\| PubMed ID: 19159665	2009
Brain edema formation and neurological impairment after subarachnoid hemorrhage in rats. Laboratory investigation. Journal of neurosurgery\| PubMed ID: 19425896	2009
Anatibant, a selective non-peptide bradykinin B2 receptor antagonist, reduces intracranial hypertension and histopathological damage after experimental traumatic brain injury. Neuroscience letters\| PubMed ID: 19429066	2009
Inhibition of bradykinin B2 receptors before, not after onset of experimental subarachnoid hemorrhage prevents brain edema formation and improves functional outcome. Critical care medicine\| PubMed ID: 19487935	2009
The novel nitric oxide synthase inhibitor 4-amino-tetrahydro-L-biopterine prevents brain edema formation and intracranial hypertension following traumatic brain injury in mice. Journal of neurotrauma\| PubMed ID: 19514849	2009
Mild hypothermia (33 degrees C) reduces intracranial hypertension and improves functional outcome after subarachnoid hemorrhage in rats. Neurosurgery\| PubMed ID: 19625915	2009
Level alterations of the 2f (1)-f (2) distortion product due to hypoxia in the guinea pig depend on the stimulus frequency. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery\| PubMed ID: 19629511	2010
The role of bradykinin B(1) and B(2) receptors for secondary brain damage after traumatic brain injury in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 19773800	2010
Temporal profile of thrombogenesis in the cerebral microcirculation after traumatic brain injury in mice. Journal of neurotrauma\| PubMed ID: 19803784	2010
Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death. Brain, behavior, and immunity\| PubMed ID: 19961923	2010
High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice. Annals of neurology\| PubMed ID: 20186955	2010
Standardized induction of subarachnoid hemorrhage in mice by intracranial pressure monitoring. Journal of neuroscience methods\| PubMed ID: 20457182	2010
BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor. Journal of neurochemistry\| PubMed ID: 20646170	2010
Characterization of a 3-vessel occlusion model for the induction of complete global cerebral ischemia in mice. Journal of neuroscience methods\| PubMed ID: 20688105	2010
Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21191088	2011
Contribution of bradykinin receptors to the development of secondary brain damage after experimental subarachnoid hemorrhage. Neurosurgery\| PubMed ID: 21242838	2011
Fluid resuscitation after traumatic brain injury with hypovolemic shock: still a bloody business? Critical care medicine\| PubMed ID: 21330861	2011
In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 21364604	2011
Role of apoptosis inducing factor (AIF) for hippocampal neuronal cell death following global cerebral ischemia in mice. Neuroscience letters\| PubMed ID: 21616126	2011
Contribution of matrix metalloproteinase-9 to cerebral edema and functional outcome following experimental subarachnoid hemorrhage. Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 21912109	2011
Vasopressin V(1a) receptors mediate posthemorrhagic systemic hypertension thereby determining rebleeding rate and outcome after experimental subarachnoid hemorrhage. Stroke; a journal of cerebral circulation\| PubMed ID: 21998059	2012
Experimental subarachnoid hemorrhage causes early and long-lasting microarterial constriction and microthrombosis: an in-vivo microscopy study. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 22146194	2012
Inhalation of nitric oxide prevents ischemic brain damage in experimental stroke by selective dilatation of collateral arterioles. Circulation research\| PubMed ID: 22207711	2012
Nitric oxide: considerations for the treatment of ischemic stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 22333622	2012
Paving the road to translation. Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 22343133	2012
Impact of anesthesia on pathophysiology and mortality following subarachnoid hemorrhage in rats. Experimental & translational stroke medicine\| PubMed ID: 22414527	2012
Inhalation of NO during myocardial ischemia reduces infarct size and improves cardiac function. Intensive care medicine\| PubMed ID: 22653370	2012
Connexin 36 promotes cortical spreading depolarization and ischemic brain damage. Brain research\| PubMed ID: 22960118	2012
Inhaled nitric oxide reduces secondary brain damage after traumatic brain injury in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 23188422	2013
Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction. The Journal of biological chemistry\| PubMed ID: 23430260	2013
Arginine vasopressin V1a receptor-deficient mice have reduced brain edema and secondary brain damage following traumatic brain injury. Journal of neurotrauma\| PubMed ID: 23441636	2013
In vivo temporal and spatial profile of leukocyte adhesion and migration after experimental traumatic brain injury in mice. Journal of neuroinflammation\| PubMed ID: 23448240	2013
Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]. Cell stem cell\| PubMed ID: 23561443	2013
Bradykinin in blood and cerebrospinal fluid after acute cerebral lesions: correlations with cerebral edema and intracranial pressure. Journal of neurotrauma\| PubMed ID: 23638655	2013
Pathophysiological Role of Global Cerebral Ischemia following Subarachnoid Hemorrhage: The Current Experimental Evidence. Stroke research and treatment\| PubMed ID: 23844316	2013
A semi-automated method for isolating functionally intact mitochondria from cultured cells and tissue biopsies. Analytical biochemistry\| PubMed ID: 23969012	2013
Inhaled nitric oxide protects males but not females from neonatal mouse hypoxia-ischemia brain injury. Translational stroke research\| PubMed ID: 24323275	2013
Preclinical phase III trials in translational stroke research: call for collective design of framework and guidelines. Stroke; a journal of cerebral circulation\| PubMed ID: 24407954	2014
Sustained alterations of hypothalamic tanycytes during posttraumatic hypopituitarism in male mice. Endocrinology\| PubMed ID: 24601879	2014
CO2 has no therapeutic effect on early microvasospasm after experimental subarachnoid hemorrhage. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 24865999	2014
Effect of small molecule vasopressin V1a and V2 receptor antagonists on brain edema formation and secondary brain damage following traumatic brain injury in mice. Journal of neurotrauma\| PubMed ID: 25111427	2015
Protocol for the induction of subarachnoid hemorrhage in mice by perforation of the Circle of Willis with an endovascular filament. Translational stroke research\| PubMed ID: 25123204	2014
The neuroprotective effect of 17β-estradiol is independent of its antioxidative properties. Brain research\| PubMed ID: 25148707	2014
Endothelial nitric oxide synthase mediates arteriolar vasodilatation after traumatic brain injury in mice. Journal of neurotrauma\| PubMed ID: 25363688	2015
Contributions of the immune system to the pathophysiology of traumatic brain injury - evidence by intravital microscopy. Frontiers in cellular neuroscience\| PubMed ID: 25408636	2014
Identification of the Vascular Source of Vasogenic Brain Edema following Traumatic Brain Injury Using In Vivo 2-Photon Microscopy in Mice. Journal of neurotrauma\| PubMed ID: 25585052	2015
Effect of decompressive craniectomy on outcome following subarachnoid hemorrhage in mice. Stroke\| PubMed ID: 25593134	2015
Dysfunction of mouse cerebral arteries during early aging. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 26058694	2015
Are We Barking Up the Wrong Vessels? Cerebral Microcirculation After Subarachnoid Hemorrhage. Stroke\| PubMed ID: 26152299	2015
Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Annals of neurology\| PubMed ID: 26312599	2015
Temporal Profile of MicroRNA Expression in Contused Cortex after Traumatic Brain Injury in Mice. Journal of neurotrauma\| PubMed ID: 26426744	2016
The immune system in traumatic brain injury. Current opinion in pharmacology\| PubMed ID: 26613129	2016
Nitric oxide inhalation reduces brain damage, prevents mortality, and improves neurological outcome after subarachnoid hemorrhage by resolving early pial microvasospasms. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 26661144	2016
Acute changes in neurovascular reactivity after subarachnoid hemorrhage in vivo. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 26676226	2017
The Formation of Microthrombi in Parenchymal Microvessels after Traumatic Brain Injury Is Independent of Coagulation Factor XI. Journal of neurotrauma\| PubMed ID: 26886854	2016
Phase III Preclinical Trials in Translational Stroke Research: Community Response on Framework and Guidelines. Translational stroke research\| PubMed ID: 27297402	2016
Inadequate food and water intake determine mortality following stroke in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 27449604	2017
Recent progress in translational research on neurovascular and neurodegenerative disorders. Restorative neurology and neuroscience\| PubMed ID: 28059802	2017
Inversion of neurovascular coupling after subarachnoid hemorrhage in vivo. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 28112024	2017
Decreased Secondary Lesion Growth and Attenuated Immune Response after Traumatic Brain Injury in Mice. Frontiers in neurology\| PubMed ID: 28912751	2017
Cylindromatosis mediates neuronal cell death in vitro and in vivo. Cell death and differentiation\| PubMed ID: 29352268	2018
Microvasospasms After Experimental Subarachnoid Hemorrhage Do Not Depend on Endothelin A Receptors. Stroke\| PubMed ID: 29438081	2018
Capillary flow disturbances after experimental subarachnoid hemorrhage: A contributor to delayed cerebral ischemia? Microcirculation (New York, N.Y. : 1994)\| PubMed ID: 30431201	2019
Plasminogen activator inhibitor-1 augments damage by impairing fibrinolysis after traumatic brain injury. Annals of neurology\| PubMed ID: 30843275	2019
Vasopressin V Receptors Regulate Cerebral Aquaporin 1 after Traumatic Brain Injury. Journal of neurotrauma\| PubMed ID: 31547764	2020
Quality of life up to 10 years after traumatic brain injury: a cross-sectional analysis. Health and quality of life outcomes\| PubMed ID: 32498679	2020
Decompressive Craniectomy Is Associated With Good Quality of Life Up to 10 Years After Rehabilitation From Traumatic Brain Injury. Critical care medicine\| PubMed ID: 32697486	2020
Contusion Rodent Model of Traumatic Brain Injury: Controlled Cortical Impact. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 32808258	2021
Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span. GeroScience\| PubMed ID: 33070278	2021
Potassium ions promote hexokinase-II dependent glycolysis. iScience\| PubMed ID: 33870140	2021
RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury. Acta neuropathologica communications\| PubMed ID: 34404478	2021
Scavenging Free Iron Reduces Arteriolar Microvasospasms After Experimental Subarachnoid Hemorrhage. Stroke\| PubMed ID: 34749506	2021
Immobilization of Recombinant Fluorescent Biosensors Permits Imaging of Extracellular Ion Signals. ACS sensors\| PubMed ID: 34752056	2021
A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons in Mammals from Ischemia by Reducing Intracellular Calcium-Mediated Excitotoxicity. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 34904402	2022
Dynamic tracing using ultra-bright labeling and multi-photon microscopy identifies endothelial uptake of poloxamer 188 coated poly(lactic-co-glycolic acid) nano-carriers in vivo. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 34915181	2022
Adhesion of Leukocytes to Cerebral Venules Precedes Neuronal Cell Death and Is Sufficient to Trigger Tissue Damage After Cerebral Ischemia. Frontiers in neurology\| PubMed ID: 35140676	2021
Perfusion pressure determines vascular integrity and histomorphological quality following perfusion fixation of the brain. Journal of neuroscience methods\| PubMed ID: 35151669	2022
Size-Selective Transfer of Lipid Nanoparticle-Based Drug Carriers Across the Blood Brain Barrier Via Vascular Occlusions Following Traumatic Brain Injury. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 35384294	2022
Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke. Journal of neuroinflammation\| PubMed ID: 38102677	2023
To see or not to see: In vivo nanocarrier detection methods in the brain and their challenges. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 38810705	2024
Probing intracellular potassium dynamics in neurons with the genetically encoded sensor lc-LysM GEPII 1.0 in vitro and in vivo. Scientific reports\| PubMed ID: 38877089	2024
Combining array tomography with electron tomography provides insights into leakiness of the blood-brain barrier in mouse cortex. eLife\| PubMed ID: 39102289	2024