Robert H. Edwards

Departments of Neurology and Physiology, University of California School of Medicine, San Francisco

Affiliated withUniversity of California School of Medicine, San Francisco

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 10	2009

Other Publications

Article	Year
Glutamine uptake by neurons: interaction of protons with system a transporters. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 11756489	2002
Regulation of the glutamine transporter SN1 by extracellular pH and intracellular sodium ions. The Journal of physiology\| PubMed ID: 11850497	2002
The glutamine commute: take the N line and transfer to the A. The Journal of cell biology\| PubMed ID: 11980913	2002
Cell-specific expression of the glutamine transporter SN1 suggests differences in dependence on the glutamine cycle. The European journal of neuroscience\| PubMed ID: 12059969	2002
Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12388602	2002
The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12388773	2002
Vesicular neurotransmitter transporter expression in developing postnatal rodent retina: GABA and glycine precede glutamate. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12533612	2003
Postnatal development of the glutamate vesicular transporter VGLUT1 in rat cerebral cortex. Brain research. Developmental brain research\| PubMed ID: 12586437	2003
The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12598615	2003
Organic anion transport is the primary function of the SLC17/type I phosphate transporter family. PflÃ¼gers Archiv : European journal of physiology\| PubMed ID: 12811560	2004
Cellular localization of three vesicular glutamate transporter mRNAs and proteins in rat spinal cord and dorsal root ganglia. Synapse (New York, N.Y.)\| PubMed ID: 12923814	2003
Complementary distribution of vesicular glutamate transporters 1 and 2 in the nucleus accumbens of rat: Relationship to calretinin-containing extrinsic innervation and calbindin-immunoreacti... The Journal of comparative neurology\| PubMed ID: 12926012	2003
Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight. The European journal of neuroscience\| PubMed ID: 12956725	2003
Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures. Hippocampus\| PubMed ID: 14620876	2003
Complementary distribution of type 1 cannabinoid receptors and vesicular glutamate transporter 3 in basal forebrain suggests input-specific retrograde signalling by cholinergic neurons. The European journal of neuroscience\| PubMed ID: 14622230	2003
Electrochemical monitoring of transport by a vesicular monoamine transporter expressed in Xenopus oocytes. Journal of neuroscience methods\| PubMed ID: 14757360	2004
VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate. Trends in neurosciences\| PubMed ID: 15102489	2004
Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science (New York, N.Y.)\| PubMed ID: 15118123	2004
Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15163690	2004
Lipid rafts mediate the synaptic localization of alpha-synuclein. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15282274	2004
Vesicular glutamate transporter 3 expression identifies glutamatergic amacrine cells in the rodent retina. The Journal of comparative neurology\| PubMed ID: 15329888	2004
Evidence that certain retinal bipolar cells use both glutamate and GABA. The Journal of comparative neurology\| PubMed ID: 15368537	2004
The effect of rare human sequence variants on the function of vesicular monoamine transporter 2. Pharmacogenetics\| PubMed ID: 15475732	2004
Normal biogenesis and cycling of empty synaptic vesicles in dopamine neurons of vesicular monoamine transporter 2 knockout mice. Molecular biology of the cell\| PubMed ID: 15496457	2005
Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters. The Journal of comparative neurology\| PubMed ID: 15515175	2004
Antidepressants and the monoamine masquerade. Neuron\| PubMed ID: 15820686	2005
A combinatorial code for the interaction of alpha-synuclein with membranes. The Journal of biological chemistry\| PubMed ID: 16020543	2005
Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines. Neuron\| PubMed ID: 16301178	2005
Neural activity controls the synaptic accumulation of alpha-synuclein. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16306404	2005
Functional implications of neurotransmitter co-release: glutamate and GABA share the load. Current opinion in pharmacology\| PubMed ID: 16359920	2006
Changes in purinergic signaling after cerebral injury -- involvement of glutamatergic mechanisms? International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 16387466	2006
Structural variants in the vesicular monoamine transporter do not contribute to sporadic Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 16450345	2006
PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network. Pharmacological reviews\| PubMed ID: 16507879	2006
Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra. The European journal of neuroscience\| PubMed ID: 16519671	2006
Distribution of vesicular glutamate transporters 1 and 2 in the rat spinal cord, with a note on the spinocervical tract. The Journal of comparative neurology\| PubMed ID: 16786558	2006
Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Neuron\| PubMed ID: 16815333	2006
Synaptic vesicles: half full or half empty? Neuron\| PubMed ID: 16950150	2006
Alpha-synuclein overexpression increases cytosolic catecholamine concentration. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16957086	2006
Secretion of L-glutamate from osteoclasts through transcytosis. The EMBO journal\| PubMed ID: 16957773	2006
Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17108165	2006
Do different endocytic pathways make different synaptic vesicles? Current opinion in neurobiology\| PubMed ID: 17449236	2007
Thyronamines inhibit plasma membrane and vesicular monoamine transport. ACS chemical biology\| PubMed ID: 17530732	2007
Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17611277	2007
Physiology versus pathology in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17623781	2007
The neurotransmitter cycle and quantal size. Neuron\| PubMed ID: 17880890	2007
Vesicular neurotransmitter transporters as targets for endogenous and exogenous toxic substances. Annual review of pharmacology and toxicology\| PubMed ID: 17883368	2008
Pharmacology of neurotransmitter transport into secretory vesicles. Handbook of experimental pharmacology\| PubMed ID: 18064412	2008
Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. Neuron\| PubMed ID: 18215623	2008
Expression and function of the rat vesicular monoamine transporter 2. American journal of physiology. Cell physiology\| PubMed ID: 18287335	2008
Vesicular glutamate and GABA transporters sort to distinct sets of vesicles in a population of presynaptic terminals. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 18502731	2009
Vesicular glutamate transporter 3-immunoreactive pericellular baskets ensheath a distinct population of neurons in the lateral septum. Journal of chemical neuroanatomy\| PubMed ID: 18611437	2008
Fast subplasma membrane Ca2+ transients control exo-endocytosis of synaptic-like microvesicles in astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18784293	2008
Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19020024	2008
Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. Neuron\| PubMed ID: 19409267	2009
Synaptic and extrasynaptic factors governing glutamatergic retinal waves. Neuron\| PubMed ID: 19409268	2009
Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals. Science (New York, N.Y.)\| PubMed ID: 19423778	2009
Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors. Nature\| PubMed ID: 19915548	2009
Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map. Nature neuroscience\| PubMed ID: 20081852	2010
Localized topological changes of the plasma membrane upon exocytosis visualized by polarized TIRFM. The Journal of cell biology\| PubMed ID: 20142424	2010
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron\| PubMed ID: 20152114	2010
The behavior of alpha-synuclein in neurons. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 20187244	2010
Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron\| PubMed ID: 20223200	2010
Vesicular monoamine and glutamate transporters select distinct synaptic vesicle recycling pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20534840	2010
Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20554874	2010
Metabolic control of vesicular glutamate transport and release. Neuron\| PubMed ID: 20920794	2010
VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21135246	2010
RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. The Journal of cell biology\| PubMed ID: 21149569	2010
Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein. The Journal of biological chemistry\| PubMed ID: 21489994	2011
Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PloS one\| PubMed ID: 21544206	2011
Pathway-specific genetic attenuation of glutamate release alters select features of competition-based visual circuit refinement. Neuron\| PubMed ID: 21791283	2011
Expression of vesicular glutamate transporters type 1 and 2 in sensory and autonomic neurons innervating the mouse colorectum. The Journal of comparative neurology\| PubMed ID: 21800314	2011
v-SNARE composition distinguishes synaptic vesicle pools. Neuron\| PubMed ID: 21835344	2011
Genetic targeting and physiological features of VGLUT3+ amacrine cells. Visual neuroscience\| PubMed ID: 21864449	2011
Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport. Nature neuroscience\| PubMed ID: 21874016	2011
Neurotransmitter corelease: mechanism and physiological role. Annual review of physiology\| PubMed ID: 22054239	2012
Vesicular and plasma membrane transporters for neurotransmitters. Cold Spring Harbor perspectives in biology\| PubMed ID: 22199021	2012
Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia. The Journal of clinical investigation\| PubMed ID: 22214848	2012