David Sulzer

Departments of Neurology, Columbia University

Affiliated withColumbia University New York Psychiatric Institute Columbia University Medical Campus

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 10	2009
Publication title Cited by 3	2018

Other Publications

Article	Year
Regulation of quantal size by presynaptic mechanisms. Reviews in the neurosciences\| PubMed ID: 10718152	2000
Dale's principle and glutamate corelease from ventral midbrain dopamine neurons. Amino acids\| PubMed ID: 11026472	2000
Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11050221	2000
The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease. FEBS letters\| PubMed ID: 11801257	2002
Transgenic superoxide dismutase overproducer: murine. Methods in enzymology\| PubMed ID: 11912908	2002
Stimulation-dependent regulation of the pH, volume and quantal size of bovine and rodent secretory vesicles. The Journal of physiology\| PubMed ID: 12122145	2002
Altered dopamine release and uptake kinetics in mice lacking D2 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12223553	2002
Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12376616	2002
Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12388602	2002
The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12388773	2002
Dopamine transport currents are promoted from curiosity to physiology. Trends in neurosciences\| PubMed ID: 12689764	2003
Intraneuronal dopamine-quinone synthesis: a review. Neurotoxicity research\| PubMed ID: 12835101	2000
D3 dopamine autoreceptors do not activate G-protein-gated inwardly rectifying potassium channel currents in substantia nigra dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12843272	2003
Intracellular patch electrochemistry: regulation of cytosolic catecholamines in chromaffin cells. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12843288	2003
Presynaptic regulation of dopaminergic neurotransmission. Journal of neurochemistry\| PubMed ID: 14511105	2003
Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics. Trends in neurosciences\| PubMed ID: 14585596	2003
Real-time decoding of dopamine concentration changes in the caudate-putamen during tonic and phasic firing. Journal of neurochemistry\| PubMed ID: 14622108	2003
Glutamate spillover in the striatum depresses dopaminergic transmission by activating group I metabotropic glutamate receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14627643	2003
Dopamine neurons mediate a fast excitatory signal via their glutamatergic synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14749442	2004
Dopamine neurons release transmitter via a flickering fusion pore. Nature neuroscience\| PubMed ID: 14990933	2004
Regulation of the development of mesencephalic dopaminergic systems by the selective expression of glial cell line-derived neurotrophic factor in their targets. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15044553	2004
Frequency-dependent modulation of dopamine release by nicotine. Nature neuroscience\| PubMed ID: 15146187	2004
Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals. Neuron\| PubMed ID: 15157425	2004
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science (New York, N.Y.)\| PubMed ID: 15333840	2004
The neuromelanin of human substantia nigra: physiological and pathogenic aspects. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society\| PubMed ID: 15541018	2004
Neurodegeneration and neuroprotection in Parkinson disease. NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 15717014	2004
Antidepressants and the monoamine masquerade. Neuron\| PubMed ID: 15820686	2005
Mechanisms of neurotransmitter release by amphetamines: a review. Progress in neurobiology\| PubMed ID: 15955613	2005
SNAREs can promote complete fusion and hemifusion as alternative outcomes. The Journal of cell biology\| PubMed ID: 16027221	2005
Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons. Journal of neurochemistry\| PubMed ID: 16092945	2005
Analysis of exocytotic events recorded by amperometry. Nature methods\| PubMed ID: 16118635	2005
Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice. Nature neuroscience\| PubMed ID: 16234811	2005
Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines. Neuron\| PubMed ID: 16301178	2005
Alpha-synuclein overexpression increases cytosolic catecholamine concentration. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16957086	2006
A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice. Brain research\| PubMed ID: 17020749	2006
Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17108165	2006
Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease. Trends in neurosciences\| PubMed ID: 17418429	2007
Parkinson's disease: return of an old prime suspect. Neuron\| PubMed ID: 17610813	2007
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. The Journal of clinical investigation\| PubMed ID: 18172548	2008
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy\| PubMed ID: 18188003	2008
PKC theta activity maintains normal quantal size in chromaffin cells. Journal of neurochemistry\| PubMed ID: 18248621	2008
Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways. Human molecular genetics\| PubMed ID: 18276609	2008
Methamphetamine inhibits antigen processing, presentation, and phagocytosis. PLoS pathogens\| PubMed ID: 18282092	2008
Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease. Journal of neurochemistry\| PubMed ID: 18384642	2008
Repeated exposure to methamphetamine causes long-lasting presynaptic corticostriatal depression that is renormalized with drug readministration. Neuron\| PubMed ID: 18400166	2008
Secretory vesicle rebound hyperacidification and increased quantal size resulting from prolonged methamphetamine exposure. Journal of neurochemistry\| PubMed ID: 19014382	2008
Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of p... The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19228951	2009
Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. Neuron\| PubMed ID: 19409267	2009
Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals. Science (New York, N.Y.)\| PubMed ID: 19423778	2009
Presynaptic regulation of dopamine transmission in schizophrenia. Schizophrenia bulletin\| PubMed ID: 19525353	2011
Glutamate controls growth rate and branching of dopaminergic axons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19776283	2009
Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease. Neurotoxicity research\| PubMed ID: 19957214	2011
Clues to how alpha-synuclein damages neurons in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 20187229	2010
Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron\| PubMed ID: 20223200	2010
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nature neuroscience\| PubMed ID: 20383138	2010
Development of pH-responsive fluorescent false neurotransmitters. Journal of the American Chemical Society\| PubMed ID: 20540519	2010
AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. The EMBO journal\| PubMed ID: 20664521	2010
How addictive drugs disrupt presynaptic dopamine neurotransmission. Neuron\| PubMed ID: 21338876	2011
Multiple personalities in the ventral tegmental area. Neuron\| PubMed ID: 21658574	2011
Imaging presynaptic exocytosis in corticostriatal slices. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21913113	2011
4-Component relativistic magnetically induced current density using London atomic orbitals. Physical chemistry chemical physics : PCCP\| PubMed ID: 22080205	2011
Constitutive upregulation of chaperone-mediated autophagy in Huntington's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22171050	2011
Regulation of presynaptic neurotransmission by macroautophagy. Neuron\| PubMed ID: 22542182	2012
Neuronal vulnerability, pathogenesis, and Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 22791686	2013
Calcium currents regulate dopamine autoreceptors. Brain : a journal of neurology\| PubMed ID: 25057130	2014
Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits. Neuron\| PubMed ID: 25155956	2014
Voluntary adolescent drinking enhances excitation by low levels of alcohol in a subset of dopaminergic neurons in the ventral tegmental area. Neuropharmacology\| PubMed ID: 27475082	2016
Dopamine's Effects on Corticostriatal Synapses during Reward-Based Behaviors. Neuron\| PubMed ID: 29420932	2018