Isabelle Broutin

Laboratoire de Cristallographie & RMN Biologiques, CNRS & Université Paris Descartes

Affiliated withCNRS & Université Paris Descartes

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 11	2014

Other Publications

Article	Year
Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. Journal of molecular biology\| PubMed ID: 11827484	2002
The PIR domain of Grb14 is an intrinsically unstructured protein: implication in insulin signaling. FEBS letters\| PubMed ID: 14623073	2003
Changes in structural dynamics of the Grb2 adaptor protein upon binding of phosphotyrosine ligand to its SH2 domain. Biochimica et biophysica acta\| PubMed ID: 15210125	2004
Solution NMR structure of the SH3 domain of human nephrocystin and analysis of a mutation-causing juvenile nephronophthisis. Proteins\| PubMed ID: 15723349	2005
Expression, purification, crystallization and preliminary X-ray studies of the outer membrane efflux proteins OprM and OprN from Pseudomonas aeruginosa. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 16511029	2005
High affinity Grb2-SH3 domain ligand incorporating Cbeta-substituted prolines in a Sos-derived decapeptide. Bioorganic & medicinal chemistry\| PubMed ID: 17113302	2007
Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: X-ray structure of Del1-9-G129R-hPRL. The Journal of biological chemistry\| PubMed ID: 17785459	2007
A non-canonical Grb2-PLC-gamma1-Sos cascade triggered by lipovitellin 1, an apolipoprotein B homologue. Cellular signalling\| PubMed ID: 17869481	2007
Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance. EMBO reports\| PubMed ID: 18292754	2008
Molecular determinants of Grb14-mediated inhibition of insulin signaling. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 19359342	2009
NKX2-1 mutations leading to surfactant protein promoter dysregulation cause interstitial lung disease in "Brain-Lung-Thyroid Syndrome". Human mutation\| PubMed ID: 20020530	2010
Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2. The Journal of biological chemistry\| PubMed ID: 20053995	2010
Structural and dynamical insights into the opening mechanism of P. aeruginosa OprM channel. Structure (London, England : 1993)\| PubMed ID: 20399187	2010
Structural characterization of the stem-stem dimerization interface between prolactin receptor chains complexed with the natural hormone. Journal of molecular biology\| PubMed ID: 20875426	2010
Mutations in INF2 are a major cause of autosomal dominant focal segmental glomerulosclerosis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 21258034	2011
Novel NOBOX loss-of-function mutations account for 6.2% of cases in a large primary ovarian insufficiency cohort. Human mutation\| PubMed ID: 21837770	2011
INF2 mutations in Charcot-Marie-Tooth disease with glomerulopathy. The New England journal of medicine\| PubMed ID: 22187985	2011
Targeting the proangiogenic VEGF-VEGFR protein-protein interface with drug-like compounds by in silico and in vitro screening. Chemistry & biology\| PubMed ID: 22195565	2011
Activity monitoring of functional OprM using a biomimetic microfluidic device. The Analyst\| PubMed ID: 22215439	2012
Photo-induced proton gradients for the in vitro investigation of bacterial efflux pumps. Scientific reports\| PubMed ID: 22400101	2012
Stoichiometry of the MexA-OprM binding, as investigated by blue native gel electrophoresis. Electrophoresis\| PubMed ID: 22589107	2012
Unusual binding of Grb2 protein to a bivalent polyproline-ligand immobilized on a SPR sensor: intermolecular bivalent binding. Biochimica et biophysica acta\| PubMed ID: 23159538	2013
Hoechst likes to play hide and seek...use it with caution! Analytical biochemistry\| PubMed ID: 23743152	2013
Contribution of asparagine 346 residue to the carbapenemase activity of CMY-2 β-lactamase. FEMS microbiology letters\| PubMed ID: 23763375	2013
Multiple mutations lead to MexXY-OprM-dependent aminoglycoside resistance in clinical strains of Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy\| PubMed ID: 24145539	2014