Linda M Pilarski

Department of Oncology, University of Alberta

Affiliated withUniversity of Alberta Cross Cancer Institute

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 16	2014

Other Publications

Article	Year
Intraclonal homogeneity of clonotypic immunoglobulin M and diversity of nonclinical post-switch isotypes in multiple myeloma: insights into the evolution of the myeloma clone. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 11839670	2002
Leukemic B cells clonally identical to myeloma plasma cells are myelomagenic in NOD/SCID mice. Experimental hematology\| PubMed ID: 11882359	2002
CD20-directed serotherapy in patients with multiple myeloma: biologic considerations and therapeutic applications. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 11924912	2002
Clonotypic myeloma cells able to xenograft myeloma to nonobese diabetic severe combined immunodeficient mice copurify with CD34 (+) hematopoietic progenitors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 12374689	2002
In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression. Blood\| PubMed ID: 12393535	2003
The malignant clone in Waldenstrom's macroglobulinemia. Seminars in oncology\| PubMed ID: 12720122	2003
Abnormal expression of hyaluronan synthases in patients with Waldenstrom's macroglobulimenia. Seminars in oncology\| PubMed ID: 12720129	2003
Improved resolution with microchip-based enhanced field inversion electrophoresis. Electrophoresis\| PubMed ID: 12783455	2003
RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability. Molecular biology of the cell\| PubMed ID: 12808028	2003
Discussion on the safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study. Gastroenterology\| PubMed ID: 14628819	2003
Clonotypic IgM V/D/J sequence analysis in Waldenstrom macroglobulinemia suggests an unusual B-cell origin and an expansion of polyclonal B cells in peripheral blood. Blood\| PubMed ID: 14764523	2004
Genetics and cytogenetics of multiple myeloma: a workshop report. Cancer research\| PubMed ID: 14989251	2004
RHAMM expression and isoform balance predict aggressive disease and poor survival in multiple myeloma. Blood\| PubMed ID: 15105292	2004
A combined dielectrophoresis, traveling wave dielectrophoresis and electrorotation microchip for the manipulation and characterization of human malignant cells. Journal of microbiological methods\| PubMed ID: 15279943	2004
Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients. Blood\| PubMed ID: 15677557	2005
Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity. Cancer research\| PubMed ID: 15705883	2005
Hyaluronan and hyaluronan synthases: potential therapeutic targets in cancer. Current drug targets. Cardiovascular & haematological disorders\| PubMed ID: 15720220	2005
Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma. Blood\| PubMed ID: 15731173	2005
Origins of Waldenstrom's macroglobulinemia: does it arise from an unusual B-cell precursor? Clinical lymphoma\| PubMed ID: 15794851	2005
Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia. Clinical lymphoma\| PubMed ID: 15794859	2005
Identification of clonotypic IgH VDJ sequences in multiple myeloma. Methods in molecular medicine\| PubMed ID: 15968099	2005
A potential role for centrosomal deregulation within IgH translocation-positive myeloma. Medical hypotheses\| PubMed ID: 16023302	2005
Sensitive detection using microfluidics technology of single cell PCR products from high and low abundance IgH VDJ templates in multiple myeloma. Journal of immunological methods\| PubMed ID: 16150455	2005
SSX cancer testis antigens are expressed in most multiple myeloma patients: co-expression of SSX1, 2, 4, and 5 correlates with adverse prognosis and high frequencies of SSX-positive PCs. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 16224274	2005
Impaired class switch recombination (CSR) in Waldenstrom macroglobulinemia (WM) despite apparently normal CSR machinery. Blood\| PubMed ID: 16317092	2006
Automated screening using microfluidic chip-based PCR and product detection to assess risk of BK virus-associated nephropathy in renal transplant recipients. Electrophoresis\| PubMed ID: 16960845	2006
Ten years and counting: so what do we know about t(4;14)(p16;q32) multiple myeloma. Leukemia & lymphoma\| PubMed ID: 17107900	2006
Molecular characterization of Waldenstrom's macroglobulinemia reveals frequent occurrence of two B-cell clones having distinct IgH VDJ sequences. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17404080	2007
Microfluidic chips for detecting the t(4;14) translocation and monitoring disease during treatment using reverse transcriptase-polymerase chain reaction analysis of IgH-MMSET hybrid transcri... The Journal of molecular diagnostics : JMD\| PubMed ID: 17591936	2007
Microfluidic platform for single nucleotide polymorphism genotyping of the thiopurine S-methyltransferase gene to evaluate risk for adverse drug events. The Journal of molecular diagnostics : JMD\| PubMed ID: 17690215	2007
Establishment of BCWM.1 cell line for Waldenström's macroglobulinemia with productive in vivo engraftment in SCID-hu mice. Experimental hematology\| PubMed ID: 17761288	2007
The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment for multiple myeloma. British journal of haematology\| PubMed ID: 18076711	2008
An inexpensive and portable microchip-based platform for integrated RT-PCR and capillary electrophoresis. The Analyst\| PubMed ID: 18299747	2008
A unique three-dimensional model for evaluating the impact of therapy on multiple myeloma. Blood\| PubMed ID: 18535198	2008
Analysis of clonotypic switch junctions reveals multiple myeloma originates from a single class switch event with ongoing mutation in the isotype-switched progeny. Blood\| PubMed ID: 18577707	2008
Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia. Blood\| PubMed ID: 18815290	2008
Altered expression of fibronectin and collagens I and IV in multiple myeloma and monoclonal gammopathy of undetermined significance. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 19001640	2009
An integrated microfluidic chip for chromosome enumeration using fluorescence in situ hybridization. Lab on a chip\| PubMed ID: 19023479	2008
Strategies for enhancing the speed and integration of microchip genetic amplification. Electrophoresis\| PubMed ID: 19053066	2008
The relationships among physiologic variables, quality of life, and fatigue in patients with multiple myeloma. Oncology nursing forum\| PubMed ID: 19273410	2009
Genetic abnormalities in Waldenström's macroglobulinemia. Clinical lymphoma & myeloma\| PubMed ID: 19362966	2009
Aberrant splice variants of HAS1 (Hyaluronan Synthase 1) multimerize with and modulate normally spliced HAS1 protein: a potential mechanism promoting human cancer. The Journal of biological chemistry\| PubMed ID: 19451652	2009
Promiscuity of translocation partners in multiple myeloma. Journal of cellular biochemistry\| PubMed ID: 20127714	2010
Multiple myeloma may include microvessel endothelial cells of malignant origin. Leukemia & lymphoma\| PubMed ID: 20233053	2010
In-gel technology for PCR genotyping and pathogen detection. Analytical chemistry\| PubMed ID: 20809605	2010
In a patient with biclonal Waldenstrom macroglobulinemia only one clone expands in three-dimensional culture and includes putative cancer stem cells. Leukemia & lymphoma\| PubMed ID: 21133724	2011
Expression, adverse prognostic significance and therapeutic small molecule inhibition of Polo-like kinase 1 in multiple myeloma. Leukemia research\| PubMed ID: 21816470	2011
Multiple Myeloma Includes Phenotypically Defined Subsets of Clonotypic CD20+ B Cells that Persist During Treatment with Rituximab. Clinical medicine. Oncology\| PubMed ID: 21892289	2008
A miniaturized and integrated gel post platform for multiparameter PCR detection of herpes simplex viruses from raw genital swabs. Lab on a chip\| PubMed ID: 22426784	2012
Differential positioning and close spatial proximity of translocation-prone genes in nonmalignant B-cells from multiple myeloma patients. Genes, chromosomes & cancer\| PubMed ID: 22489023	2012
In multiple myeloma, bone-marrow lymphocytes harboring the same chromosomal abnormalities as autologous plasma cells predict poor survival. American journal of hematology\| PubMed ID: 22495885	2012
In non-transplant patients with multiple myeloma, the pre-treatment level of clonotypic cells predicts event-free survival. Molecular cancer\| PubMed ID: 23083101	2012
Alteration of introns in a hyaluronan synthase 1 (HAS1) minigene convert Pre-mRNA [corrected] splicing to the aberrant pattern in multiple myeloma (MM): MM patients harbor similar changes. PloS one\| PubMed ID: 23301075	2013
Differential nuclear organization of translocation-prone genes in nonmalignant B cells from patients with t(14;16) as compared with t(4;14) or t(11;14) myeloma. Genes, chromosomes & cancer\| PubMed ID: 23460268	2013
An enclosed in-gel PCR amplification cassette with multi-target, multi-sample detection for platform molecular diagnostics. Lab on a chip\| PubMed ID: 23471315	2013
Aberrant splicing, hyaluronan synthases and intracellular hyaluronan as drivers of oncogenesis and potential drug targets. Current cancer drug targets\| PubMed ID: 23517594	2013
The systemic cytokine environment is permanently altered in multiple myeloma. PloS one\| PubMed ID: 23544044	2013
Frequent occurrence of highly expanded but unrelated B-cell clones in patients with multiple myeloma. PloS one\| PubMed ID: 23724106	2013
Storing self-contained gel capillary cassettes for POC medical diagnostics. Lab on a chip\| PubMed ID: 23966212	2013
A novel method for sample delivery and testing of whole blood: gel strip PCR for point of care (POC) molecular diagnostics. Lab on a chip\| PubMed ID: 23966268	2013