Y. Eugene Chen

Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center

Affiliated withUniversity of Michigan Medical Center

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 32	2013
Publication title Cited by 5	2019

Other Publications

Article	Year
Biochemical characterization and cellular effects of CADASIL mutants of NOTCH3. PloS one\| PubMed ID: 23028706	2012
A highly efficient method to differentiate smooth muscle cells from human embryonic stem cells. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 18029907	2007
Rad GTPase deficiency leads to cardiac hypertrophy. Circulation\| PubMed ID: 18056528	2007
Molecular recognition of nitrated fatty acids by PPAR gamma. Nature structural & molecular biology\| PubMed ID: 18604218	2008
A comparison of murine smooth muscle cells generated from embryonic versus induced pluripotent stem cells. Stem cells and development\| PubMed ID: 18795840	2009
Gene expression module-based chemical function similarity search. Nucleic acids research\| PubMed ID: 18842630	2008
PPARs and the cardiovascular system. Antioxidants & redox signaling\| PubMed ID: 19061437	2009
Beneficial effect of young oocytes for rabbit somatic cell nuclear transfer. Cloning and stem cells\| PubMed ID: 19090660	2009
PPARgamma and its ligands: therapeutic implications in cardiovascular disease. Clinical science (London, England : 1979)\| PubMed ID: 19118492	2009
Expression profiling of nuclear receptors in human and mouse embryonic stem cells. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 19196830	2009
Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation. Circulation\| PubMed ID: 19221220	2009
Vascular smooth muscle cell-selective peroxisome proliferator-activated receptor-gamma deletion leads to hypotension. Circulation\| PubMed ID: 19364979	2009
The role of peroxisome proliferator-activated receptor gamma in blood pressure regulation. Current hypertension reports\| PubMed ID: 19602323	2009
Nitro-fatty acid inhibition of neointima formation after endoluminal vessel injury. Circulation research\| PubMed ID: 19797175	2009
Human C-reactive protein does not promote atherosclerosis in transgenic rabbits. Circulation\| PubMed ID: 19901190	2009
Disruption of inducible 6-phosphofructo-2-kinase ameliorates diet-induced adiposity but exacerbates systemic insulin resistance and adipose tissue inflammatory response. The Journal of biological chemistry\| PubMed ID: 19948719	2010
miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia. Neurobiology of disease\| PubMed ID: 20053374	2010
Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actions. The Journal of biological chemistry\| PubMed ID: 20097754	2010
miR-10a contributes to retinoid acid-induced smooth muscle cell differentiation. The Journal of biological chemistry\| PubMed ID: 20118242	2010
Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation. The Journal of biological chemistry\| PubMed ID: 20439457	2010
Peroxisome proliferator-activated receptor delta regulation of miR-15a in ischemia-induced cerebral vascular endothelial injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20445066	2010
Involvement of inducible 6-phosphofructo-2-kinase in the anti-diabetic effect of peroxisome proliferator-activated receptor gamma activation in mice. The Journal of biological chemistry\| PubMed ID: 20498376	2010
Nitro-oleic acid inhibits angiotensin II-induced hypertension. Circulation research\| PubMed ID: 20558825	2010
Vascular smooth muscle cell peroxisome proliferator-activated receptor-γ deletion promotes abdominal aortic aneurysms. Journal of vascular surgery\| PubMed ID: 20630681	2010
Porous nanofibrous PLLA scaffolds for vascular tissue engineering. Biomaterials\| PubMed ID: 20673997	2010
MicroRNA-1 regulates smooth muscle cell differentiation by repressing Kruppel-like factor 4. Stem cells and development\| PubMed ID: 20799856	2011
Vascular smooth muscle cell peroxisome proliferator-activated receptor-γ mediates pioglitazone-reduced vascular lesion formation. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21088248	2011
Vascular PPARδ protects against stroke-induced brain injury. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21205987	2011
Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor. Cardiovascular research\| PubMed ID: 21382976	2011
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis. The EMBO journal\| PubMed ID: 21407177	2011
Three-dimensional growth of iPS cell-derived smooth muscle cells on nanofibrous scaffolds. Biomaterials\| PubMed ID: 21439638	2011
Combined therapeutic strategy to improve vascular endothelial function after implantation of sirolimus-eluting stents. Circulation journal : official journal of the Japanese Circulation Society\| PubMed ID: 21467654	2011
Generation of PPARγ mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning. Cell research\| PubMed ID: 21502977	2011
Platelet-derived growth factor induces Rad expression through Egr-1 in vascular smooth muscle cells. PloS one\| PubMed ID: 21559360	2011
Developmental patterns of PPAR and RXR gene expression during spermatogenesis. Frontiers in bioscience (Elite edition)\| PubMed ID: 21622127	2011
Vascular cell lineage determination and differentiation. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21677288	2011
Smooth muscle cell differentiation in vitro: models and underlying molecular mechanisms. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21677291	2011
Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1. American journal of physiology. Cell physiology\| PubMed ID: 21734188	2011
Monocyte chemotactic protein-induced protein 1 (MCPIP1) suppresses stress granule formation and determines apoptosis under stress. The Journal of biological chemistry\| PubMed ID: 21971051	2011
Inhibition of gluconeogenic genes by calcium-regulated heat-stable protein 1 via repression of peroxisome proliferator-activated receptor α. The Journal of biological chemistry\| PubMed ID: 21990353	2011
Follicular oocytes better support development in rabbit cloning than oviductal oocytes. Cellular reprogramming\| PubMed ID: 22029417	2011
Identification and mechanism of 10-carbon fatty acid as modulating ligand of peroxisome proliferator-activated receptors. The Journal of biological chemistry\| PubMed ID: 22039047	2012
Smooth muscle cells for vascular engineering. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 22096093	2011
MicroRNA and vascular smooth muscle cells. Vitamins and hormones\| PubMed ID: 22127249	2011
Endothelial lipase mediates HDL levels in normal and hyperlipidemic rabbits. Journal of atherosclerosis and thrombosis\| PubMed ID: 22240910	2012
Spatial and temporal distribution of Oct-4 and acetylated H4K5 in rabbit embryos. Reproductive biomedicine online\| PubMed ID: 22381206	2012
Yap1 protein regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin. The Journal of biological chemistry\| PubMed ID: 22411986	2012
Mitochondrial dysfunction and adipogenic reduction by prohibitin silencing in 3T3-L1 cells. PloS one\| PubMed ID: 22479600	2012
A novel strategy for deciphering dynamic conservation of gene expression relationship. Journal of molecular cell biology\| PubMed ID: 22498922	2012
Construction of vascular tissues with macro-porous nano-fibrous scaffolds and smooth muscle cells enriched from differentiated embryonic stem cells. PloS one\| PubMed ID: 22545119	2012
Vascular endothelial cell-specific microRNA-15a inhibits angiogenesis in hindlimb ischemia. The Journal of biological chemistry\| PubMed ID: 22692216	2012
Recombinant rabbit leukemia inhibitory factor and rabbit embryonic fibroblasts support the derivation and maintenance of rabbit embryonic stem cells. Cellular reprogramming\| PubMed ID: 22775411	2012
Disruption of inducible 6-phosphofructo-2-kinase impairs the suppressive effect of PPARγ activation on diet-induced intestine inflammatory response. The Journal of nutritional biochemistry\| PubMed ID: 22841546	2013
Loss of perivascular adipose tissue on peroxisome proliferator-activated receptor-γ deletion in smooth muscle cells impairs intravascular thermoregulation and enhances atherosclerosis. Circulation\| PubMed ID: 22855570	2012
Dynamic profiles of Oct-4, Cdx-2 and acetylated H4K5 in in-vivo-derived rabbit embryos. Reproductive biomedicine online\| PubMed ID: 22877942	2012
Krüppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-κB signaling pathway. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23042817	2012
Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ. The Journal of biological chemistry\| PubMed ID: 23060450	2012
Diabetic HDL is dysfunctional in stimulating endothelial cell migration and proliferation due to down regulation of SR-BI expression. PloS one\| PubMed ID: 23133640	2012
Paradoxical roles of perivascular adipose tissue in atherosclerosis and hypertension. Circulation journal : official journal of the Japanese Circulation Society\| PubMed ID: 23207957	2013
Human apolipoprotein A-II protects against diet-induced atherosclerosis in transgenic rabbits. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23241412	2013
Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in ... The Journal of biological chemistry\| PubMed ID: 23264620	2013
Electrophilic nitro-fatty acids inhibit vascular inflammation by disrupting LPS-dependent TLR4 signalling in lipid rafts. Cardiovascular research\| PubMed ID: 23334216	2013
Zc3h12c inhibits vascular inflammation by repressing NF-κB activation and pro-inflammatory gene expression in endothelial cells. The Biochemical journal\| PubMed ID: 23360436	2013
KLF11 mediates PPARγ cerebrovascular protection in ischaemic stroke. Brain : a journal of neurology\| PubMed ID: 23408111	2013
MCPIP1 negatively regulates toll-like receptor 4 signaling and protects mice from LPS-induced septic shock. Cellular signalling\| PubMed ID: 23422584	2013
Dietary obesity-induced Egr-1 in adipocytes facilitates energy storage via suppression of FOXC2. Scientific reports\| PubMed ID: 23502673	2013
Angiogenesis-Regulating microRNAs and Ischemic Stroke. Current vascular pharmacology\| PubMed ID: 23713863	2013
The Application of SILAC Mouse in Human Body Fluid Proteomics Analysis Reveals Protein Patterns Associated with IgA Nephropathy. Evidence-based complementary and alternative medicine : eCAM\| PubMed ID: 23762118	2013
MiR-27 Targets Prohibitin and Impairs Adipocyte Differentiation and Mitochondrial Function in Human Adipose-derived Stem Cells. The Journal of biological chemistry\| PubMed ID: 24133204	2013
SysFinder: A customized platform for search, comparison and assisted design of appropriate animal models based on systematic similarity. Journal of genetics and genomics = Yi chuan xue bao\| PubMed ID: 28529081	2017
Production of immunodeficient rabbits by multiplex embryo transfer and multiplex gene targeting. Scientific reports\| PubMed ID: 28939872	2017
Genomic and Transcriptomic Analysis of Hypercholesterolemic Rabbits: Progress and Perspectives. International journal of molecular sciences\| PubMed ID: 30413026	2018