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JoVE Journal
Medicine

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Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases
 

Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases

Article DOI: 10.3791/50957
November 18th, 2013

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Summary November 18th, 2013

Recent development in gene targeting tools makes production of knockout (KO) rabbits possible. In the present work, we generated five Apolipoprotein (Apo) C-III KO rabbits using Zinc Finger Nucleases (ZFN). This work demonstrated that ZFN is a highly efficient method to produce KO rabbits.

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