Owen J.T. McCarty

Department of Biomedical Engineering, Oregon Health & Science University, School of Medicine

Affiliated withOregon Health & Science University, School of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 11	2014

Other Publications

Article	Year
Comparative efficacy between the glycoprotein IIb/IIIa antagonists roxifiban and orbofiban in inhibiting platelet responses in flow models of thrombosis. Journal of cardiovascular pharmacology\| PubMed ID: 11904529	2002
Fluid shear regulates the kinetics and molecular mechanisms of activation-dependent platelet binding to colon carcinoma cells. Biophysical journal\| PubMed ID: 12124268	2002
Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to platelets in shear flow. American journal of physiology. Cell physiology\| PubMed ID: 12529243	2003
Evaluation of platelet antagonists in in vitro flow models of thrombosis. Methods in molecular medicine\| PubMed ID: 14733325	2004
Preferential binding of platelets to monocytes over neutrophils under flow. Biochemical and biophysical research communications\| PubMed ID: 15721313	2005
Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. The Journal of biological chemistry\| PubMed ID: 16195235	2005
Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI. Blood\| PubMed ID: 16219796	2006
Distinct but critical roles for integrin alphaIIbbeta3 in platelet lamellipodia formation on fibrinogen, collagen-related peptide and thrombin. The FEBS journal\| PubMed ID: 17032352	2006
Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3. The Biochemical journal\| PubMed ID: 17054426	2007
GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 17110603	2007
Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates. Blood\| PubMed ID: 17227834	2007
Minimal regulation of platelet activity by PECAM-1. Platelets\| PubMed ID: 17365855	2007
The leech product saratin is a potent inhibitor of platelet integrin alpha2beta1 and von Willebrand factor binding to collagen. The FEBS journal\| PubMed ID: 17489103	2007
Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 17962622	2008
Capture of flowing endothelial cells using surface-immobilized anti-kinase insert domain receptor antibody. Tissue engineering. Part C, Methods\| PubMed ID: 18544026	2008
Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI. Blood\| PubMed ID: 18945968	2009
Distinct extracellular matrix microenvironments of progenitor and carotid endothelial cells. Journal of biomedical materials research. Part A\| PubMed ID: 18985765	2009
Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19116273	2009
Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19141632	2009
Single particle quantum dot imaging achieves ultrasensitive detection capabilities for Western immunoblot analysis. ACS nano\| PubMed ID: 19453141	2009
Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2). Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19661487	2009
Effect of sex difference on platelet adhesion, spreading and aggregate formation under flow. Thrombosis and haemostasis\| PubMed ID: 19888535	2009
Cytoskeletal structure regulates endothelial cell immunogenicity independent of fluid shear stress. American journal of physiology. Cell physiology\| PubMed ID: 19923423	2010
Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear. PloS one\| PubMed ID: 20454680	2010
Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encepha... Journal of neuroimmunology\| PubMed ID: 20546940	2010
Safety and antithrombotic efficacy of moderate platelet count reduction by thrombopoietin inhibition in primates. Science translational medicine\| PubMed ID: 20574069	2010
A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo. Blood\| PubMed ID: 20634381	2010
Molecular imaging of activated von Willebrand factor to detect high-risk atherosclerotic phenotype. JACC. Cardiovascular imaging\| PubMed ID: 20846630	2010
Breakup feared after filamin leaves GPIb. Blood\| PubMed ID: 21372161	2011
Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke. Stroke; a journal of cerebral circulation\| PubMed ID: 21512172	2011
S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation. Blood\| PubMed ID: 21757621	2011
Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes. Journal of leukocyte biology\| PubMed ID: 21807745	2011
Platelet shape change and spreading. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22130702	2012
Optical detection of indocyanine green encapsulated biocompatible poly (lactic-co-glycolic) acid nanoparticles with photothermal optical coherence tomography. Optics letters\| PubMed ID: 22378459	2012
Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis. Blood\| PubMed ID: 22442348	2012
Regulation of the mTOR-Rac1 axis in platelet function. Small GTPases\| PubMed ID: 22714420	2012
Optical quantification of cellular mass, volume, and density of circulating tumor cells identified in an ovarian cancer patient. Frontiers in oncology\| PubMed ID: 22826822	2012
Hyaluronan anchored to activated CD44 on central nervous system vascular endothelial cells promotes lymphocyte extravasation in experimental autoimmune encephalomyelitis. The Journal of biological chemistry\| PubMed ID: 22865853	2012
Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient. Frontiers in oncology\| PubMed ID: 22934287	2012
Development of coagulation factor probes for the identification of procoagulant circulating tumor cells. Frontiers in oncology\| PubMed ID: 22973554	2012
Do circulating tumor cells play a role in coagulation and thrombosis? Frontiers in oncology\| PubMed ID: 22973557	2012
Measurement of single cell refractive index, dry mass, volume, and density using a transillumination microscope. Physical review letters\| PubMed ID: 23005682	2012
Modeling and simulation of procoagulant circulating tumor cells in flow. Frontiers in oncology\| PubMed ID: 23050240	2012
Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation. American journal of physiology. Cell physiology\| PubMed ID: 23174566	2013
Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition. Circulation. Cardiovascular imaging\| PubMed ID: 23239832	2013
Gammaherpesvirus latency induces antibody-associated thrombocytopenia in mice. Journal of autoimmunity\| PubMed ID: 23245703	2013
Hyaluronan oligosaccharides perturb lymphocyte slow rolling on brain vascular endothelial cells: implications for inflammatory demyelinating disease. Matrix biology : journal of the International Society for Matrix Biology\| PubMed ID: 23333375	2013
Quantification of volume, mass, and density of thrombus formation using brightfield and differential interference contrast microscopy. Journal of biomedical optics\| PubMed ID: 23348747	2013
Physiological levels of blood coagulation factors IX and X control coagulation kinetics in an in vitro model of circulating tissue factor. Physical biology\| PubMed ID: 23585459	2013
Development of a Label-free Imaging Technique for the Quantification of Thrombus Formation. Cellular and molecular bioengineering\| PubMed ID: 23585817	2012
A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific reports\| PubMed ID: 23618955	2013
Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice. Translational stroke research\| PubMed ID: 23634198	2012
p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23640496	2013
Microfluidics and coagulation biology. Annual review of biomedical engineering\| PubMed ID: 23642241	2013
Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps via regulation of autophagy. American journal of physiology. Cell physiology\| PubMed ID: 23720022	2013
The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. American journal of physiology. Cell physiology\| PubMed ID: 23784547	2013
Role of coagulation in the recruitment of colon adenocarcinoma cells to thrombus under shear. American journal of physiology. Cell physiology\| PubMed ID: 23903698	2013
p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. PloS one\| PubMed ID: 24019894	2013
Histone deacetylase 6-mediated deacetylation of α-tubulin coordinates cytoskeletal and signaling events during platelet activation. American journal of physiology. Cell physiology\| PubMed ID: 24025866	2013
A theme series on physical biology in cancer in AJP-Cell. American journal of physiology. Cell physiology\| PubMed ID: 24067917	2014
Phosphatidylserine index as a marker of the procoagulant phenotype of acute myelogenous leukemia cells. Physical biology\| PubMed ID: 24104188	2013
Physical biology in cancer. 2. The physical biology of circulating tumor cells. American journal of physiology. Cell physiology\| PubMed ID: 24133063	2014
Rac and Cdc42 team up for platelets. Blood\| PubMed ID: 24178962	2013
Factor XII inhibition reduces thrombus formation in a primate thrombosis model. Blood\| PubMed ID: 24408325	2014
Network signatures of nuclear and cytoplasmic density alterations in a model of pre and postmetastatic colorectal cancer. Journal of biomedical optics\| PubMed ID: 24441943	2014
Measurement science in the circulatory system. Cellular and molecular bioengineering\| PubMed ID: 24563678	2014