sensing-barrier-tissue-disruption-with-an-organic-electrochemical

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

The gastrointestinal tract is an example of barrier tissue that provides a physical barrier against entry of pathogens and toxins, while allowing the ...

Ecole Nationale Superieure des Mines

Optical pressure sensors are highly responsive and are unaffected by surrounding parameters such as electronic noise, humidity, temperature, etc. A new type of optical pressure sensor is described that demonstrates the stretchability and transparency of a polydimethylsiloxane waveguide, while also serving as a substrate. The pressure sensors are both robust and easy to fabricate over a large area.

Transparent, optical, pressure-sensitive artificial skin for large-area stretchable electronics.

Carbon allotropes possess unique and interesting physical, chemical, and electronic properties that make them attractive for next-generation electronic devices and solar cells. In this report, we describe our efforts into the fabrication of the first reported all-carbon solar cell in which all components (the anode, active layer, and cathode) are carbon based. First, we evaluate the active layer, on standard electrodes, which is composed of a bilayer of polymer sorted semiconducting single-walled carbon nanotubes and C(60). This carbon-based active layer with a standard indium tin oxide anode and metallic cathode has a maximum power conversion efficiency of 0.46% under AM1.5 Sun illumination. Next, we describe our efforts in replacing the electrodes with carbon-based electrodes, to demonstrate the first all-carbon solar cell, and discuss the remaining challenges associated with this process.

Evaluation of solution-processable carbon-based electrodes for all-carbon solar cells.

Ion flow across polarized epithelia is a tightly regulated process. Measurement of the transepithelial resistance is a highly relevant parameter for assessing the function or health of the tissue. Dynamic, electrical measurements of transepithelial ion flow are preferred as they provide the most accurate snapshot of effects of external stimuli. Enteric pathogens such as Salmonella typhimurium are known to disrupt ion flow in gastrointestinal epithelia. Here, for the first time, the use of organic transistors as a powerful potential alternative for front-line, disposable, high-throughput diagnostics of enteric pathogens is demonstrated. The transistors' ability to detect early and subtle changes in transepithelial ion flow is capitalized upon to develop a highly sensitive detector of epithelial integrity. Stable operation of the organic devices under physiological conditions is shown, followed by dynamic, pathogen-specific diagnosis of infection of epithelia. Further, operation of the device is possible in complex matrices, showing particular promise for food and safety applications.

Article	Year
Transparent, optical, pressure-sensitive artificial skin for large-area stretchable electronics. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 22641411	2012
Evaluation of solution-processable carbon-based electrodes for all-carbon solar cells. ACS nano\| PubMed ID: 23113673	2012
Dynamic Monitoring of Salmonella typhimurium Infection of Polarized Epithelia Using Organic Transistors. Advanced healthcare materials\| PubMed ID: 24497469	2014

Marc Ramuz

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