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JoVE Journal
Bioengineering

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Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
 

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Article DOI: 10.3791/51102
February 10th, 2014

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Summary February 10th, 2014

The Organic Electrochemical Transistor is integrated with live cells and used to monitor ion flux across the gastrointestinal epithelial barrier. In this study, an increase in ion flux, related to disruption of tight junctions, induced by the presence of the calcium chelator EGTA (ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetra acetic acid), is measured.

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