Florian Krammer

Department of Microbiology, Icahn School of Medicine at Mount Sinai

Affiliated withIcahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 182	2013
Publication title Cited by 10	2017

Other Publications

Article	Year
Swine-origin pandemic H1N1 influenza virus-like particles produced in insect cells induce hemagglutination inhibiting antibodies in BALB/c mice. Biotechnology journal\| PubMed ID: 20041443	2010
Trichoplusia ni cells (High Five) are highly efficient for the production of influenza A virus-like particles: a comparison of two insect cell lines as production platforms for influenza vac... Molecular biotechnology\| PubMed ID: 20300881	2010
Influenza virus-like particles as an antigen-carrier platform for the ESAT-6 epitope of Mycobacterium tuberculosis. Journal of virological methods\| PubMed ID: 20304011	2010
Alternative influenza vaccines made by insect cells. Trends in molecular medicine\| PubMed ID: 20570562	2010
Evaluation of the influenza A replicon for transient expression of recombinant proteins in mammalian cells. PloS one\| PubMed ID: 20949004	2010
Insect cells for antibody production: evaluation of an efficient alternative. Journal of biotechnology\| PubMed ID: 21477625	2011
Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22308500	2012
Efficient transmission of pandemic H1N1 influenza viruses with high-level oseltamivir resistance. Journal of virology\| PubMed ID: 22345446	2012
Influenza viruses expressing chimeric hemagglutinins: globular head and stalk domains derived from different subtypes. Journal of virology\| PubMed ID: 22398287	2012
Attenuated influenza virus construct with enhanced hemagglutinin protein expression. Journal of virology\| PubMed ID: 22398291	2012
A pan-H1 anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy in vivo. Journal of virology\| PubMed ID: 22491456	2012
Influenza virus infection in guinea pigs raised as livestock, Ecuador. Emerging infectious diseases\| PubMed ID: 22710350	2012
NS1-truncated live attenuated virus vaccine provides robust protection to aged mice from viral challenge. Journal of virology\| PubMed ID: 22787224	2012
Hemagglutinin Stalk-Reactive Antibodies Are Boosted following Sequential Infection with Seasonal and Pandemic H1N1 Influenza Virus in Mice. Journal of virology\| PubMed ID: 22787225	2012
A carboxy-terminal trimerization domain stabilizes conformational epitopes on the stalk domain of soluble recombinant hemagglutinin substrates. PloS one\| PubMed ID: 22928001	2012
1976 and 2009 H1N1 influenza virus vaccines boost anti-hemagglutinin stalk antibodies in humans. The Journal of infectious diseases\| PubMed ID: 23087428	2013
Residual baculovirus in insect cell-derived influenza virus-like particle preparations enhances immunogenicity. PloS one\| PubMed ID: 23236516	2012
H3N2 influenza virus infection induces broadly reactive hemagglutinin stalk antibodies in humans and mice. Journal of virology\| PubMed ID: 23408625	2013
Chimeric hemagglutinin influenza virus vaccine constructs elicit broadly protective stalk-specific antibodies. Journal of virology\| PubMed ID: 23576508	2013
B cell response and hemagglutinin stalk-reactive antibody production in different age cohorts following 2009 H1N1 influenza virus vaccination. Clinical and vaccine immunology : CVI\| PubMed ID: 23576673	2013
Purification of infective baculoviruses by monoliths. Journal of chromatography. A\| PubMed ID: 23587319	2013
Recombinant IgA is sufficient to prevent influenza virus transmission in guinea pigs. Journal of virology\| PubMed ID: 23698296	2013
Induction of cross-reactive antibodies to novel H7N9 influenza virus by recombinant Newcastle disease virus expressing a North American lineage H7 subtype hemagglutinin. Journal of virology\| PubMed ID: 23698299	2013
Neutralizing antibodies against previously encountered influenza virus strains increase over time: a longitudinal analysis. Science translational medicine\| PubMed ID: 23946196	2013
H7N9 influenza viruses interact preferentially with α2,3-linked sialic acids and bind weakly to α2,6-linked sialic acids. The Journal of general virology\| PubMed ID: 23950563	2013
Influenza virus hemagglutinin stalk-based antibodies and vaccines. Current opinion in virology\| PubMed ID: 23978327	2013
The emergence of H7N9 viruses: a chance to redefine correlates of protection for influenza virus vaccines. Expert review of vaccines\| PubMed ID: 24160815	2013
Adjuvants and immunization strategies to induce influenza virus hemagglutinin stalk antibodies. PloS one\| PubMed ID: 24223176	2013
One-shot vaccination with an insect cell-derived low-dose influenza A H7 virus-like particle preparation protects mice against H7N9 challenge. Vaccine\| PubMed ID: 24262313	2014
H3 stalk-based chimeric hemagglutinin influenza virus constructs protect mice from H7N9 challenge. Journal of virology\| PubMed ID: 24307585	2014
Influenza A(H7N9) virus gains neuraminidase inhibitor resistance without loss of in vivo virulence or transmissibility. Nature communications\| PubMed ID: 24326875	2013
Universal influenza virus vaccines: need for clinical trials. Nature immunology\| PubMed ID: 24352315	2014
Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets. Journal of virology\| PubMed ID: 24403585	2014
Divergent H7 immunogens offer protection from H7N9 virus challenge. Journal of virology\| PubMed ID: 24453375	2014
An H7N1 influenza virus vaccine induces broadly reactive antibody responses against H7N9 in humans. Clinical and vaccine immunology : CVI\| PubMed ID: 24943383	2014
In the shadow of hemagglutinin: a growing interest in influenza viral neuraminidase and its role as a vaccine antigen. Viruses\| PubMed ID: 24960271	2014
Advances in universal influenza virus vaccine design and antibody mediated therapies based on conserved regions of the hemagglutinin. Current topics in microbiology and immunology\| PubMed ID: 25007847	2015
Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25157133	2014
Induction of broadly reactive anti-hemagglutinin stalk antibodies by an H5N1 vaccine in humans. Journal of virology\| PubMed ID: 25210189	2014
Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin. Journal of virology\| PubMed ID: 25210195	2014
Animal models for influenza viruses: implications for universal vaccine development. Pathogens (Basel, Switzerland)\| PubMed ID: 25436508	2014
A viable recombinant rhabdovirus lacking its glycoprotein gene and expressing influenza virus hemagglutinin and neuraminidase is a potent influenza vaccine. Journal of virology\| PubMed ID: 25540378	2015
Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses. Journal of virology\| PubMed ID: 25568203	2015
An H10N8 influenza virus vaccine strain and mouse challenge model based on the human isolate A/Jiangxi-Donghu/346/13. Vaccine\| PubMed ID: 25604801	2015
Domestic pigs are susceptible to infection with influenza B viruses. Journal of virology\| PubMed ID: 25673727	2015
Preexisting human antibodies neutralize recently emerged H7N9 influenza strains. The Journal of clinical investigation\| PubMed ID: 25689254	2015
Advances in the development of influenza virus vaccines. Nature reviews. Drug discovery\| PubMed ID: 25722244	2015
Emerging influenza viruses and the prospect of a universal influenza virus vaccine. Biotechnology journal\| PubMed ID: 25728134	2015
Vaccination with adjuvanted recombinant neuraminidase induces broad heterologous, but not heterosubtypic, cross-protection against influenza virus infection in mice. mBio\| PubMed ID: 25759506	2015
High-Affinity H7 Head and Stalk Domain-Specific Antibody Responses to an Inactivated Influenza H7N7 Vaccine After Priming With Live Attenuated Influenza Vaccine. The Journal of infectious diseases\| PubMed ID: 25838266	2015
Newcastle Disease Virus-Vectored H7 and H5 Live Vaccines Protect Chickens from Challenge with H7N9 or H5N1 Avian Influenza Viruses. Journal of virology\| PubMed ID: 25926639	2015
High Affinity Antibodies against Influenza Characterize the Plasmablast Response in SLE Patients After Vaccination. PloS one\| PubMed ID: 25951191	2015
Vaccination with soluble headless hemagglutinin protects mice from challenge with divergent influenza viruses. Vaccine\| PubMed ID: 26026378	2015
Hemagglutinin Receptor Binding of a Human Isolate of Influenza A(H10N8) Virus. Emerging infectious diseases\| PubMed ID: 26079843	2015
Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy. Cell\| PubMed ID: 26140596	2015
The Quest for a Universal Flu Vaccine: Headless HA 2.0. Cell host & microbe\| PubMed ID: 26468743	2015
Hemagglutinin Stalk- and Neuraminidase-Specific Monoclonal Antibodies Protect against Lethal H10N8 Influenza Virus Infection in Mice. Journal of virology\| PubMed ID: 26512088	2015
Ion efflux and influenza infection trigger NLRP3 inflammasome signaling in human dendritic cells. Journal of leukocyte biology\| PubMed ID: 26574023	2016
Immune history profoundly affects broadly protective B cell responses to influenza. Science translational medicine\| PubMed ID: 26631631	2015
Vaccination with Vesicular Stomatitis Virus-Vectored Chimeric Hemagglutinins Protects Mice against Divergent Influenza Virus Challenge Strains. Journal of virology\| PubMed ID: 26676789	2015
Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets. Journal of virology\| PubMed ID: 26719251	2015
Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins. Journal of virology\| PubMed ID: 26764009	2016
Age Dependence and Isotype Specificity of Influenza Virus Hemagglutinin Stalk-Reactive Antibodies in Humans. mBio\| PubMed ID: 26787832	2016
New England harbor seal H3N8 influenza virus retains avian-like receptor specificity. Scientific reports\| PubMed ID: 26888262	2016
Novel universal influenza virus vaccine approaches. Current opinion in virology\| PubMed ID: 26927813	2016
Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate. mBio\| PubMed ID: 27006464	2016
Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection. PLoS pathogens\| PubMed ID: 27081859	2016
Globular Head-Displayed Conserved Influenza H1 Hemagglutinin Stalk Epitopes Confer Protection against Heterologous H1N1 Virus. PloS one\| PubMed ID: 27088239	2016
Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection. Cell host & microbe\| PubMed ID: 27281570	2016
Obesity Outweighs Protection Conferred by Adjuvanted Influenza Vaccination. mBio\| PubMed ID: 27486196	2016
Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27647907	2016
Canine H3N8 influenza vaccines partially protect mice against the canine H3N2 strain currently circulating in the United States. Vaccine\| PubMed ID: 27670073	2016
Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27698132	2016
Cross-Reactive and Cross-Neutralizing Activity of Human Mumps Antibodies Against a Novel Mumps Virus From Bats. The Journal of infectious diseases\| PubMed ID: 27811320	2017
Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination. Nature medicine\| PubMed ID: 27820605	2016
Influenza virus-specific antibody dependent cellular cytoxicity induced by vaccination or natural infection. Vaccine\| PubMed ID: 27914742	2017
Progesterone-Based Contraceptives Reduce Adaptive Immune Responses and Protection against Sequential Influenza A Virus Infections. Journal of virology\| PubMed ID: 28179523	2017
Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins. Nature immunology\| PubMed ID: 28192418	2017
A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses. PLoS pathogens\| PubMed ID: 28278235	2017
Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin. mBio\| PubMed ID: 28325769	2017
Chimeric Hemagglutinin Constructs Induce Broad Protection against Influenza B Virus Challenge in the Mouse Model. Journal of virology\| PubMed ID: 28356526	2017
Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity. Science (New York, N.Y.)\| PubMed ID: 28360135	2017
Induction of Broadly Cross-Reactive Stalk-Specific Antibody Responses to Influenza Group 1 and Group 2 Hemagglutinins by Natural H7N9 Virus Infection in Humans. The Journal of infectious diseases\| PubMed ID: 28380622	2017
An Amphibian Host Defense Peptide Is Virucidal for Human H1 Hemagglutinin-Bearing Influenza Viruses. Immunity\| PubMed ID: 28423338	2017
Stopping emerging influenza viruses at their origin. The Lancet. Infectious diseases\| PubMed ID: 28533095	2017
Novel Cross-Reactive Monoclonal Antibodies against Ebolavirus Glycoproteins Show Protection in a Murine Challenge Model. Journal of virology\| PubMed ID: 28592526	2017
A cross-clade H5N1 influenza A virus neutralizing monoclonal antibody binds to a novel epitope within the vestigial esterase domain of hemagglutinin. Antiviral research\| PubMed ID: 28633988	2017
Is It Possible to Develop a "Universal" Influenza Virus Vaccine? Toward a Universal Influenza Virus Vaccine: Potential Target Antigens and Critical Aspects for Vaccine Development. Cold Spring Harbor perspectives in biology\| PubMed ID: 28663209	2017
Synthetic TLR4 and TLR7 ligands work additively via MyD88 to induce protective antiviral immunity in mice. Journal of virology\| PubMed ID: 28724768	2017
Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes. Nature microbiology\| PubMed ID: 28827718	2017