Arthur L. Horwich

Department of Genetics, Yale School of Medicine

Affiliated withYale School of Medicine Howard Hughes Medical Institute

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 9	2014

Other Publications

Article	Year
ClpS, a substrate modulator of the ClpAP machine. Molecular cell\| PubMed ID: 11931773	2002
NMR analysis of a 900K GroEL GroES complex. Nature\| PubMed ID: 12110894	2002
Solution NMR techniques for large molecular and supramolecular structures. Journal of the American Chemical Society\| PubMed ID: 12371854	2002
Folding with and without encapsulation by cis- and trans-only GroEL-GroES complexes. The EMBO journal\| PubMed ID: 12839985	2003
Role of the gamma-phosphate of ATP in triggering protein folding by GroEL-GroES: function, structure and energetics. The EMBO journal\| PubMed ID: 14517228	2003
Chaperonin-mediated protein folding: fate of substrate polypeptide. Quarterly reviews of biophysics\| PubMed ID: 14686103	2003
Uniform and residue-specific 15N-labeling of proteins on a highly deuterated background. Journal of biomolecular NMR\| PubMed ID: 15213427	2004
Exploring the structural dynamics of the E.coli chaperonin GroEL using translation-libration-screw crystallographic refinement of intermediate states. Journal of molecular biology\| PubMed ID: 15313620	2004
A mutant chaperonin with rearranged inter-ring electrostatic contacts and temperature-sensitive dissociation. Nature structural & molecular biology\| PubMed ID: 15475965	2004
Substrate polypeptide presents a load on the apical domains of the chaperonin GroEL. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15479763	2004
Chaperoned protein disaggregation--the ClpB ring uses its central channel. Cell\| PubMed ID: 15550237	2004
No evidence for a forced-unfolding mechanism during ATP/GroES binding to substrate-bound GroEL: no observable protection of metastable Rubisco intermediate or GroEL-bound Rubisco from tritiu... FEBS letters\| PubMed ID: 15710410	2005
Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocation. Cell\| PubMed ID: 15989953	2005
Direct NMR observation of a substrate protein bound to the chaperonin GroEL. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16116078	2005
Roles of the N-domains of the ClpA unfoldase in binding substrate proteins and in stable complex formation with the ClpP protease. The Journal of biological chemistry\| PubMed ID: 16207718	2005
Probing the sequence of conformationally induced polarity changes in the molecular chaperonin GroEL with fluorescence spectroscopy. The journal of physical chemistry. B\| PubMed ID: 16375456	2005
Allosteric signaling of ATP hydrolysis in GroEL-GroES complexes. Nature structural & molecular biology\| PubMed ID: 16429154	2006
GroEL-GroES-mediated protein folding. Chemical reviews\| PubMed ID: 16683761	2006
Proton-proton Overhauser NMR spectroscopy with polypeptide chains in large structures. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17032756	2006
Global aggregation of newly translated proteins in an Escherichia coli strain deficient of the chaperonin GroEL. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17043235	2006
Disulfide formation as a probe of folding in GroEL-GroES reveals correct formation of long-range bonds and editing of incorrect short-range ones. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17283341	2007
Perturbed ATPase activity and not "close confinement" of substrate in the cis cavity affects rates of folding by tail-multiplied GroEL. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17372195	2007
Two families of chaperonin: physiology and mechanism. Annual review of cell and developmental biology\| PubMed ID: 17489689	2007
Topologies of a substrate protein bound to the chaperonin GroEL. Molecular cell\| PubMed ID: 17499047	2007
Folding trajectories of human dihydrofolate reductase inside the GroEL GroES chaperonin cavity and free in solution. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18093916	2007
Multiple states of a nucleotide-bound group 2 chaperonin. Structure (London, England : 1993)\| PubMed ID: 18400175	2008
Chaperonin chamber accelerates protein folding through passive action of preventing aggregation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18987317	2008
Requirement for binding multiple ATPs to convert a GroEL ring to the folding-active state. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19050077	2008
A small molecule inhibitor selective for a variant ATP-binding site of the chaperonin GroEL. Bioorganic & medicinal chemistry letters\| PubMed ID: 19110421	2009
An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans. PLoS genetics\| PubMed ID: 19165329	2009
Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19171884	2009
The GroEL/GroES cis cavity as a passive anti-aggregation device. FEBS letters\| PubMed ID: 19577567	2009
Chaperonin-mediated protein folding: using a central cavity to kinetically assist polypeptide chain folding. Quarterly reviews of biophysics\| PubMed ID: 19638247	2009
GroEL/GroES cycling: ATP binds to an open ring before substrate protein favoring protein binding and production of the native state. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19915138	2009
ATP-triggered ADP release from the asymmetric chaperonin GroEL/GroES/ADP7 is not the rate-limiting step of the GroEL/GroES reaction cycle. FEBS letters\| PubMed ID: 20083109	2010
Double mutant MBP refolds at same rate in free solution as inside the GroEL/GroES chaperonin chamber when aggregation in free solution is prevented. FEBS letters\| PubMed ID: 21609718	2011
Nuclear magnetic resonance spectroscopy with the stringent substrate rhodanese bound to the single-ring variant SR1 of the E. coli chaperonin GroEL. Protein science : a publication of the Protein Society\| PubMed ID: 21633984	2011
Hydrogen-deuterium exchange in vivo to measure turnover of an ALS-associated mutant SOD1 protein in spinal cord of mice. Protein science : a publication of the Protein Society\| PubMed ID: 21780215	2011
Localization of GroEL determined by in vivo incorporation of a fluorescent amino acid. Bioorganic & medicinal chemistry letters\| PubMed ID: 21890355	2011
Translational diffusion of macromolecular assemblies measured using transverse-relaxation-optimized pulsed field gradient NMR. Journal of the American Chemical Society\| PubMed ID: 21919531	2011
Protein folding in the cell: an inside story. Nature medicine\| PubMed ID: 21989012	2011
QnAs with Arthur L. Horwich. Interview by Prashant Nair. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22308493	2012
ATP-triggered conformational changes delineate substrate-binding and -folding mechanics of the GroEL chaperonin. Cell\| PubMed ID: 22445172	2012
Structure and allostery of the chaperonin GroEL. Journal of molecular biology\| PubMed ID: 23183375	2013
RNA-Seq profiling of spinal cord motor neurons from a presymptomatic SOD1 ALS mouse. PloS one\| PubMed ID: 23301088	2013
Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23359680	2013
Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23509252	2013
Chaperonin-mediated protein folding. The Journal of biological chemistry\| PubMed ID: 23803606	2013