initiation-metastatic-breast-carcinoma-targeting-ductal-epithelium

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

Breast cancer is a heterogeneous disease involving complex cellular interactions between the developing tumor and immune system, eventually resulting in ...

Wistar Institute

To compare post-cesarean complications between HIV-infected women on highly active antiretroviral therapy (HAART) and a matched group of non-HIV-infected women, and to evaluate predisposing risk factors for these complications in the HIV group.

Perioperative cesarean delivery morbidity among HIV-infected women under highly active antiretroviral treatment: a case-control study.

The aim of this study is to assess the efficacy of cervical interleukin-6 (IL-6) compared with cervical length and its association in the prediction of preterm delivery in symptomatic women.

Cervical interleukin-6 as a predictive test for preterm delivery in symptomatic women: preliminary results.

To summarize the molecular processes involved in fetal programming, to describe how assisted reproduction technologies (ART) may affect the epigenetic pattern of the embryo, and to highlight the current knowledge of the role of perinatal events in the subsequent development of reproductive pathology affecting infertile patients.

Reproductive medicine and inheritance of infertility by offspring: the role of fetal programming.

To assess maternal, neonatal and graft outcomes after pregnancy in patients with kidney transplantation, and to compare the immunosuppressive therapies used.

Pregnancy outcomes after kidney transplantation-immunosuppressive therapy comparison.

Threshold values of follicle count for the definition of PCO.

To ascertain if there are differences in umbilical cord blood gas analysis between immediate and delayed cord clamping.

Effect of delayed umbilical cord clamping on blood gas analysis.

The effects of acellular dermal matrix in expander-implant breast reconstruction after total skin-sparing mastectomy.

Since 1978, we have witnessed a successful evolution of assisted reproductive technology (ART), with improvement of the pregnancy rates and a growing demand. However, in recent years, there has been increasing concern regarding its safety due to the potential health impact on its infants. The raise of the developmental origins of adult disease has positioned low birth weight (LBW) as a significant health issue. Although multiple studies have associated ART with LBW, the etiology of this association remains largely unknown. We review the potential association between different components of ART and infertility with LBW, while acknowledging the limitations of interpretation of the existing literature.

Low birth weight: is it related to assisted reproductive technology or underlying infertility?

To determine the potential clinical use of cervical interleukin-6 (IL-6) as a negative predictor of preterm birth in symptomatic women. Study design: Observational prospective study carried out in a tertiary hospital.

The negative predictive value of cervical interleukin-6 for the risk assessment of preterm birth.

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. There are multiple ways to induce ovulation in PCOS patients, which will eventually provide a successful live birth. Each of these treatments varies in aggressiveness and effectiveness. Ranging from lifestyle modifications, through insulin-sensitizing agents, selective estrogen receptor modulators, aromatase inhibitors, gonadotropins, to laparoscopic ovarian drilling and assisted reproductive techniques, each method achieves ovulation induction through different mechanisms of action. This review provides a description and specific characteristics of the different methods used for ovulation induction which can help to design a personalized approach to each PCOS patient, and a general stepwise approach to ovulation induction in these patients.

Ovulation induction in women with polycystic ovary syndrome.

Abstract Objective: To assess soluble fms-like tyrosin kinase 1 (sFlt-1), free vascular endothelial growth factor (f-VEGF) and the f-VEGF/sFlt-1 quotient in twin pregnancies, and to determine if they are impaired in discordant twins. Methods: Case-control study between 18 discordant and 46 concordant twin pregnancies. Angiogenic growth factors were measured in maternal serum during pregnancy and in umbilical artery and vein at birth. Results: Discordant twins were more often conceived by assisted reproductive techniques than concordant twins. Maternal plasma f-VEGF was significantly lower in discordant twins (p = 0.04). F-VEGF and f-VEGF/sFlt-1 in the whole sample show a significant higher level in concordant twins. When we analyzed umbilical cord angiogenic factors, the smaller twin had a lower f-VEGF/sFlt-1 quotient (p = 0.01). We found no correlations between maternal or umbilical growth factors and placental or fetal weight. No difference was found in veno-arterial levels of angiogenic factors in each twin; however, there was a significant rise in arterial f-VEGF (p = 0.06) in discordant twins. Conclusion: Mothers of discordant twins have a more anti-angiogenic environment compared to those of concordant twins. We also found an anti-angiogenic environment in the small twin when we compared umbilical vein angiogenic factors against its big co-twin.

Article	Year
Perioperative cesarean delivery morbidity among HIV-infected women under highly active antiretroviral treatment: a case-control study. European journal of obstetrics, gynecology, and reproductive biology\| PubMed ID: 20675036	2010
Cervical interleukin-6 as a predictive test for preterm delivery in symptomatic women: preliminary results. European journal of obstetrics, gynecology, and reproductive biology\| PubMed ID: 21130555	2011
Reproductive medicine and inheritance of infertility by offspring: the role of fetal programming. Fertility and sterility\| PubMed ID: 21794856	2011
Pregnancy outcomes after kidney transplantation-immunosuppressive therapy comparison. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians\| PubMed ID: 22117162	2012
Threshold values of follicle count for the definition of PCO. Human reproduction (Oxford, England)\| PubMed ID: 22398257	2012
Effect of delayed umbilical cord clamping on blood gas analysis. European journal of obstetrics, gynecology, and reproductive biology\| PubMed ID: 22405491	2012
The effects of acellular dermal matrix in expander-implant breast reconstruction after total skin-sparing mastectomy. Plastic and reconstructive surgery\| PubMed ID: 23358027	2013
Low birth weight: is it related to assisted reproductive technology or underlying infertility? Fertility and sterility\| PubMed ID: 23375144	2013
The negative predictive value of cervical interleukin-6 for the risk assessment of preterm birth. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians\| PubMed ID: 23480455	2013
Ovulation induction in women with polycystic ovary syndrome. Steroids\| PubMed ID: 23707553	2013
Angiogenic growth factors in maternal and fetal serum in concordant and discordant twin pregnancies. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians\| PubMed ID: 24041202	2013

Alfredo Perales-Puchalt

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