Cleo Kontoravdi

Centre for Process Systems Engineering, Imperial College London

Research Area

Biography

Cleo Kontoravdi holds M.Eng. and Ph.D. degrees in Chemical Engineering from Imperial College London. After working as a R&D Scientist at Lonza Biologics she re-joined the Department of Chemical Engineering at Imperial College London, where she is now a Professor of Biological Systems Engineering.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title	2014
Publication title Cited by 1	2022

Other Publications

Article	Year
Mild hypothermic culture conditions affect residual host cell protein composition post-Protein A chromatography. mAbs\| PubMed ID: 29381421	2018
Application of global sensitivity analysis to determine goals for design of experiments: an example study on antibody-producing cell cultures. Biotechnology progress\| PubMed ID: 16080692	2005
Modeling amino acid metabolism in mammalian cells-toward the development of a model library. Biotechnology progress\| PubMed ID: 17949105	2007
Towards the implementation of quality by design to the production of therapeutic monoclonal antibodies with desired glycosylation patterns. Biotechnology progress\| PubMed ID: 20665659	2010
A dynamic mathematical model for monoclonal antibody N-linked glycosylation and nucleotide sugar donor transport within a maturing Golgi apparatus. Biotechnology progress\| PubMed ID: 21956887	2011
Metabolic network reconstruction: advances in in silico interpretation of analytical information. Current opinion in biotechnology\| PubMed ID: 22119273	2012
Genome-based kinetic modeling of cytosolic glucose metabolism in industrially relevant cell lines: Saccharomyces cerevisiae and Chinese hamster ovary cells. Bioprocess and biosystems engineering\| PubMed ID: 22286123	2012
The role of ER stress-induced apoptosis in neurodegeneration. Current Alzheimer research\| PubMed ID: 22299619	2012
Quantification of intracellular nucleotide sugars and formulation of a mathematical model for prediction of their metabolism. BMC proceedings\| PubMed ID: 22373482	2011
In situ monitoring of intracellular glucose and glutamine in CHO cell culture. PloS one\| PubMed ID: 22509313	2012
Analysis of the landscape of biologically-derived pharmaceuticals in Europe: Dominant production systems, molecule types on the rise and approval trends. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 23262060	2012
Integration of models and experimentation to optimise the production of potential biotherapeutics. Drug discovery today\| PubMed ID: 23850703	2013
A systems biology approach to optimising hosts for industrial protein production. Biotechnology letters\| PubMed ID: 23892981	2013
Systematic methodology for the development of mathematical models for biological processes. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23996448	2013
An optimized method for extraction and quantification of nucleotides and nucleotide sugars from mammalian cells. Analytical biochemistry\| PubMed ID: 24036437	2013
Comparative analysis of amino acid metabolism and transport in CHO variants with different levels of productivity. Journal of biotechnology\| PubMed ID: 24056080	2013
Analysis of Chinese hamster ovary cell metabolism through a combined computational and experimental approach. Cytotechnology\| PubMed ID: 24292563	2013
Towards controlling the glycoform: a model framework linking extracellular metabolites to antibody glycosylation. International journal of molecular sciences\| PubMed ID: 24637934	2014
A framework for the systematic design of fed-batch strategies in mammalian cell culture. Biotechnology and bioengineering\| PubMed ID: 24975682	2014
Genetically-encoded biosensors for monitoring cellular stress in bioprocessing. Current opinion in biotechnology\| PubMed ID: 25151059	2015
How does mild hypothermia affect monoclonal antibody glycosylation? Biotechnology and bioengineering\| PubMed ID: 25545631	2015
A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture. Biotechnology and bioengineering\| PubMed ID: 25899530	2015
Advances in the Development of Biotherapeutics. BioMed research international\| PubMed ID: 26078963	2015
Modelling of amorphous cellulose depolymerisation by cellulases, parametric studies and optimisation. Biochemical engineering journal\| PubMed ID: 26865832	2016
A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation. Scientific reports\| PubMed ID: 27345611	2016
Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia. Biotechnology and bioengineering\| PubMed ID: 27869292	2017
Whole-cell Escherichia coli lactate biosensor for monitoring mammalian cell cultures during biopharmaceutical production. Biotechnology and bioengineering\| PubMed ID: 28112405	2017
Cascading effect in bioprocessing-The impact of mild hypothermia on CHO cell behavior and host cell protein composition. Biotechnology and bioengineering\| PubMed ID: 28843000	2017
Exploring cellular behavior under transient gene expression and its impact on mAb productivity and Fc-glycosylation. Biotechnology and bioengineering\| PubMed ID: 28921534	2018
Host cell protein removal from biopharmaceutical preparations: Towards the implementation of quality by design. Biotechnology advances\| PubMed ID: 29654903	2018
Emerging Technologies for Low-Cost, Rapid Vaccine Manufacture. Biotechnology journal\| PubMed ID: 30537361	2019
Model-based optimization of antibody galactosylation in CHO cell culture. Biotechnology and bioengineering\| PubMed ID: 30802295	2019
Low-cost and user-friendly biosensor to test the integrity of mRNA molecules suitable for field applications. Biosensors & bioelectronics\| PubMed ID: 31100599	2019
Harnessing the potential of artificial neural networks for predicting protein glycosylation. Metabolic engineering communications\| PubMed ID: 32489858	2020
High resolution biosensor to test the capping level and integrity of mRNAs. Nucleic acids research\| PubMed ID: 33152073	2020
The era of big data: Genome-scale modelling meets machine learning. Computational and structural biotechnology journal\| PubMed ID: 33240470	2020
Resources, Production Scales and Time Required for Producing RNA Vaccines for the Global Pandemic Demand. Vaccines\| PubMed ID: 33374802	2020
Design, Development and Optimization of a Functional Mammalian Cell-Free Protein Synthesis Platform. Frontiers in bioengineering and biotechnology\| PubMed ID: 33604330	2020
Glycoengineering Chinese hamster ovary cells: a short history. Biochemical Society transactions\| PubMed ID: 33704400	2021
Correction: Kis, Z. et al. Resources, Production Scales and Time Required for Producing RNA Vaccines for the Global Pandemic Demand. 2021, , 3. Vaccines\| PubMed ID: 33804590	2021
Osmolality Effects on CHO Cell Growth, Cell Volume, Antibody Productivity and Glycosylation. International journal of molecular sciences\| PubMed ID: 33804825	2021
Quality by design modelling to support rapid RNA vaccine production against emerging infectious diseases. NPJ vaccines\| PubMed ID: 33927197	2021
Rapid development and deployment of high-volume vaccines for pandemic response. Journal of advanced manufacturing and processing\| PubMed ID: 33977274	2020
An experimental approach probing the conformational transitions and energy landscape of antibodies: a glimmer of hope for reviving lost therapeutic candidates using ionic liquid. Chemical science\| PubMed ID: 34349928	2021
Hitting the sweet spot with capillary electrophoresis: advances in N-glycomics and glycoproteomics. Current opinion in biotechnology\| PubMed ID: 34438131	2021
Rapid Antibody Glycoengineering in CHO Cells Via RNA Interference and CGE-LIF N-Glycomics. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 34611868	2022
Cell-free protein synthesis using Chinese hamster ovary cells. Methods in enzymology\| PubMed ID: 34752298	2021
Model Identifies Genetic Predisposition of Alzheimer's Disease as Key Decider in Cell Susceptibility to Stress. International journal of molecular sciences\| PubMed ID: 34769426	2021
Model-Based Planning and Delivery of Mass Vaccination Campaigns against Infectious Disease: Application to the COVID-19 Pandemic in the UK. Vaccines\| PubMed ID: 34960206	2021
Pandemic-response adenoviral vector and RNA vaccine manufacturing. NPJ vaccines\| PubMed ID: 35236838	2022
Polymer Encapsulation of Bacterial Biosensors Enables Coculture with Mammalian Cells. ACS synthetic biology\| PubMed ID: 35245022	2022
Population balance modelling captures host cell protein dynamics in CHO cell cultures. PloS one\| PubMed ID: 35320326	2022
Quality by Design for enabling RNA platform production processes. Trends in biotechnology\| PubMed ID: 35491266	2022
Immunoglobulin G N-glycan Biomarkers for Autoimmune Diseases: Current State and a Glycoinformatics Perspective. International journal of molecular sciences\| PubMed ID: 35563570	2022