anti-nuclear-antibody-screening-using-hep-2-cells

Anti-Nuclear Antibody Screening Using HEp-2 Cells

The American College of Rheumatology position statement on ANA testing stipulates the use of IIF as the gold standard method for ANA screening1. Although ...

INOVA Diagnostics, Inc.

To compare smooth muscle antibody (SMA) patterns in tissue sections with patterns in an immunofluorescence assay (IFA) using a rat intestinal epithelial cell line and results from an F-actin IgG ELISA.

'Actin-reactive' discriminated from 'non-actin-reactive' smooth muscle autoantibody by immunofluorescence reactivity with rat epithelial cell line.

Autoantibodies to the non-collagen region (NC1) of the alpha-3 subunit of collagen IV represent a serological hallmark in the diagnosis of Goodpasture's syndrome (GPS). The objective of our study was to carefully analyze the performance characteristics of a novel anti-glomerular basement membrane (GBM) chemiluminescence immunoassay (CIA).

Article	Year
'Actin-reactive' discriminated from 'non-actin-reactive' smooth muscle autoantibody by immunofluorescence reactivity with rat epithelial cell line. Pathology\| PubMed ID: 20632824	2010
Performance evaluation of a novel chemiluminescence assay for detection of anti-GBM antibodies: an international multicenter study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 21562146	2012

Carol Buchner

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