Hiroaki Taniguchi

Laboratory for Genetic Code, Doshisha University

Affiliated withDoshisha University Nihon University Institute of Genetics and Animal Breeding of the Polish Academy of Sciences

Research Area

Biography

Hiroaki Taniguchi is an assistant professor and a team leader of laboratory for Genome Editing and Transcriptional Regulation at Institute of Genetics and Animal Breeding of the Polish Academy of Sciences. He received a Ph.D. from Université Laval (Faculty of Medicine, CANADA). His current research focuses on CRISPR-mediated gene editing and transcriptional gene regulation in the field of regenerative medicine, reproductive biology, and cancer biology.

JoVE Journal Publications

ArticleTotal : 6	Year
Publication title Cited by 7	2014
Publication title Cited by 4	2016
Publication title	2016
Publication title Cited by 1	2017
Publication title Cited by 6	2018

Other Publications

Article	Year
High plasma levels of matrix metalloproteinase-8 in patients with unstable angina. Atherosclerosis\| PubMed ID: 19674746	2010
The lipoxygenase pathways are involved in LH-stimulated progesterone production in bovine corpus luteum. Prostaglandins & other lipid mediators\| PubMed ID: 11789897	2002
Fas-Fas ligand system mediates luteal cell death in bovine corpus luteum. Biology of reproduction\| PubMed ID: 11870083	2002
Comparison of green tea intake in Japanese patients with and without angiographic coronary artery disease. The American journal of cardiology\| PubMed ID: 12423723	2002
Association of trypsin expression with tumour progression and matrilysin expression in human colorectal cancer. The Journal of pathology\| PubMed ID: 12533830	2003
[Expression of trypsin and cancer proliferation in colorectal neoplasms]. Nihon rinsho. Japanese journal of clinical medicine\| PubMed ID: 14574885	2003
Expression of ets-related transcriptional factor E1AF is associated with tumor progression and over-expression of matrilysin in human gastric cancer. Carcinogenesis\| PubMed ID: 14604892	2004
Plasma osteopontin levels are associated with the presence and extent of coronary artery disease. Atherosclerosis\| PubMed ID: 14612215	2003
[Beneficial effect of glucocorticosteroids for esophageal varices due to idiopathic portal hypertension following systemic lupus erythematosus]. Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology\| PubMed ID: 15045815	2004
In vivo magnetic resonance evaluation of associations between aortic atherosclerosis and both risk factors and coronary artery disease in patients referred for coronary angiography. American heart journal\| PubMed ID: 15215803	2004
Role of the GATA family of transcription factors in andrology. Journal of andrology\| PubMed ID: 15223831	2004
Association of Mycoplasma pneumoniae infection with coronary artery disease and its interaction with chlamydial infection. Atherosclerosis\| PubMed ID: 15306186	2004
Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma. Carcinogenesis\| PubMed ID: 15333466	2004
[Abnormal fluorine-18 fluorodeoxy-glucose uptakes in the aorta and subclavian artery of a 66-year-old woman]. Journal of cardiology\| PubMed ID: 15500163	2004
[Three successful case reports of advanced gastric cancer with chemotherapy]. Gan to kagaku ryoho. Cancer & chemotherapy\| PubMed ID: 15553684	2004
An oxidized low-density lipoprotein receptor gene variant is inversely associated with the severity of coronary artery disease. Clinical cardiology\| PubMed ID: 15562935	2004
Associations of plasma C-reactive protein levels with the presence and extent of coronary stenosis in patients with stable coronary artery disease. Atherosclerosis\| PubMed ID: 15585215	2005
Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of c... Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15585629	2004
Levels of matrix metalloproteinase-1 in patients with and without coronary artery disease and relation to complex and noncomplex coronary plaques. The American journal of cardiology\| PubMed ID: 15619398	2005
Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis. Carcinogenesis\| PubMed ID: 15695237	2005
Effect of lipid-lowering therapy with atorvastatin on atherosclerotic aortic plaques detected by noninvasive magnetic resonance imaging. Journal of the American College of Cardiology\| PubMed ID: 15734619	2005
GATA factors and the nuclear receptors, steroidogenic factor 1/liver receptor homolog 1, are key mutual partners in the regulation of the human 3beta-hydroxysteroid dehydrogenase type 2 prom... Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 15928316	2005
Lack of any association between persistent hepatitis B or C virus infection and coronary artery disease. Atherosclerosis\| PubMed ID: 15939074	2005
Polymorphism of the 3'-untranslated region of interleukin-12 p40 gene is not associated with the presence or severity of coronary artery disease. Circulation journal : official journal of the Japanese Circulation Society\| PubMed ID: 15988104	2005
Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers. Oncogene\| PubMed ID: 16007117	2005
Associations between serum resistin levels and insulin resistance, inflammation, and coronary artery disease. Journal of the American College of Cardiology\| PubMed ID: 16022972	2005
Protein kinase A-dependent synergism between GATA factors and the nuclear receptor, liver receptor homolog-1, regulates human aromatase (CYP19) PII promoter activity in breast cancer cells. Endocrinology\| PubMed ID: 16109788	2005
Plasma matrix metalloproteinase-8 concentrations are associated with the presence and severity of coronary artery disease. Circulation journal : official journal of the Japanese Circulation Society\| PubMed ID: 16127182	2005
Green tea consumption and serum malondialdehyde-modified LDL concentrations in healthy subjects. Journal of the American College of Nutrition\| PubMed ID: 16192258	2005
High plasma levels of osteopontin in patients with restenosis after percutaneous coronary intervention. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 16373617	2006
A possible association between coronary plaque instability and complex plaques in abdominal aorta. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 16424346	2006
LDL fractions assessed by anion-exchange high-performance liquid chromatography in patients with coronary artery disease. Atherosclerosis\| PubMed ID: 16620833	2006
Association between osteoprotegerin gene polymorphism and coronary artery disease in Japanese men. Atherosclerosis\| PubMed ID: 16678184	2006
Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 16809031	2006
LRH-1/NR5A2 cooperates with GATA factors to regulate inhibin alpha-subunit promoter activity. Molecular and cellular endocrinology\| PubMed ID: 16893604	2006
Mutational analysis of beta-catenin and the RAS-RAF signalling pathway in early flat-type colorectal tumours. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 17011185	2006
Flat-type colorectal advanced adenomas (laterally spreading tumors) have different genetic and epigenetic alterations from protruded-type advanced adenomas. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 17143260	2007
Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers. Carcinogenesis\| PubMed ID: 17183069	2007
Effect of bezafibrate therapy on atherosclerotic aortic plaques detected by MRI in dyslipidemic patients with hypertriglyceridemia. Atherosclerosis\| PubMed ID: 17196967	2008
Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability. Cancer letters\| PubMed ID: 17374440	2007
Magnetic resonance evaluation of the associations of thoracic and abdominal aortic plaques with the presence and extent of coronary artery stenosis. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance\| PubMed ID: 18066744	2007
Correlation of laterally spreading type and JC virus with methylator phenotype status in colorectal adenoma. Human pathology\| PubMed ID: 18284934	2008
A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation. BMC molecular biology\| PubMed ID: 18445271	2008
Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer. World journal of gastroenterology\| PubMed ID: 18461655	2008
LDL-3 fraction levels in patients with unstable angina: Assessment by anion-exchange high-performance liquid chromatography. Atherosclerosis\| PubMed ID: 18687436	2009
Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers. World journal of gastroenterology\| PubMed ID: 18837080	2008
The effect of human GATA4 gene mutations on the activity of target gonadal promoters. Journal of molecular endocrinology\| PubMed ID: 19008335	2009
Prognostic significance of plasma osteopontin levels in patients undergoing percutaneous coronary intervention. Circulation journal : official journal of the Japanese Circulation Society\| PubMed ID: 19023151	2009
Cross-sectional, prospective study of MRI reproducibility in the assessment of plaque burden of the carotid arteries and aorta. Nature clinical practice. Cardiovascular medicine\| PubMed ID: 19174763	2009
Effect of lipid-lowering therapy with atorvastatin on atherosclerotic aortic plaques: a 2-year follow-up by noninvasive MRI. European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology\| PubMed ID: 19242355	2009
The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA. Nucleic acids research\| PubMed ID: 19270063	2009
Cardiovascular magnetic resonance parameters of atherosclerotic plaque burden improve discrimination of prior major adverse cardiovascular events. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance\| PubMed ID: 19393089	2009
The expression of the nuclear receptors NR5A1 and NR5A2 and transcription factor GATA6 correlates with steroidogenic gene expression in the bovine corpus luteum. Molecular reproduction and development\| PubMed ID: 19455657	2009
Overexpression of beta3/gamma2 chains of laminin-5 and MMP7 in biliary cancer. World journal of gastroenterology\| PubMed ID: 19701966	2009
Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies. Cancer research\| PubMed ID: 19861541	2009
Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen. World journal of gastroenterology\| PubMed ID: 19938198	2009
Associations between plasma osteopontin levels and the severities of coronary and aortic atherosclerosis. Atherosclerosis\| PubMed ID: 20074733	2010
Epidermal growth factor receptor is an obligatory intermediate for oxytocin-induced cyclooxygenase 2 expression and prostaglandin F2 alpha production in bovine endometrial epithelial cells. Endocrinology\| PubMed ID: 20080869	2010
Associations between plasma C-reactive protein levels and the severities of coronary and aortic atherosclerosis. Journal of atherosclerosis and thrombosis\| PubMed ID: 20134100	2010
Association of glypican-3 expression with growth signaling molecules in hepatocellular carcinoma. World journal of gastroenterology\| PubMed ID: 20653060	2010
Antitumor effect of inhalatory lipopolysaccharide and synergetic effect in combination with cyclophosphamide. Anticancer research\| PubMed ID: 20871031	2010
Cytotoxic effects of activated alveolar macrophages on lung carcinoma cells via cell-to-cell contact and nitric oxide. Anticancer research\| PubMed ID: 20871032	2010
Lipopolysaccharide-activated alveolar macrophages having cytotoxicity toward lung tumor cells through cell-to-cell binding-dependent mechanism. Anticancer research\| PubMed ID: 20871035	2010
Serum resistin levels and cardiovascular events in patients undergoing percutaneous coronary intervention. Journal of atherosclerosis and thrombosis\| PubMed ID: 21071880	2011
Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 21317879	2011
A DNA methylation fingerprint of 1628 human samples. Genome research\| PubMed ID: 21613409	2012
Co-expression of laminin β3 and γ2 chains and epigenetic inactivation of laminin α3 chain in gastric cancer. International journal of oncology\| PubMed ID: 21617852	2011
The efficacy of IGF-I receptor monoclonal antibody against human gastrointestinal carcinomas is independent of k-ras mutation status. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21642381	2011
A case of anti-GA1 antibody-positive Fisher syndrome with elevated tau protein in cerebrospinal fluid. Brain & development\| PubMed ID: 21742448	2012
Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers. Cancer science\| PubMed ID: 22044563	2012
Chromatin modification of Notch targets in olfactory receptor neuron diversification. Nature neuroscience\| PubMed ID: 22197833	2011
Associations between serum lipoprotein(a) levels and the severity of coronary and aortic atherosclerosis. Atherosclerosis\| PubMed ID: 22387060	2012
Heterogeneity in clonal nature in the smoldering subtype of adult T-cell leukemia: continuity from carrier status to smoldering ATL. International journal of hematology\| PubMed ID: 22453915	2012
The LDL-cholesterol to HDL-cholesterol ratio and the severity of coronary and aortic atherosclerosis. Atherosclerosis\| PubMed ID: 22516791	2012
Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer. World journal of gastroenterology\| PubMed ID: 22719182	2012
Association between kidney dysfuction and the severity of coronary and aortic atherosclerosis. Atherosclerosis\| PubMed ID: 22770127	2012
Treatment of relapsed adult T-cell leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation: the Nagasaki Transplant Group experience. Blood\| PubMed ID: 23100309	2013
[An overview of antibody therapy against cancer]. Nihon rinsho. Japanese journal of clinical medicine\| PubMed ID: 23259378	2012
[Prevention of tumour invasion]. Nihon rinsho. Japanese journal of clinical medicine\| PubMed ID: 23513830	2012
Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids. World journal of gastroenterology\| PubMed ID: 23555160	2013
The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression. Molecular and cellular biology\| PubMed ID: 23816881	2013
The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine\| PubMed ID: 24026884	2014
Molecular analysis of the BCR-ABL1 kinase domain in chronic-phase chronic myelogenous leukemia treated with tyrosine kinase inhibitors in practice: study by the Nagasaki CML Study Group. Leukemia research\| PubMed ID: 24262285	2014
[Outcome of patients with relapsed/refractory adult T-cell leukemia-lymphoma after salvage therapy]. [Rinshō ketsueki] The Japanese journal of clinical hematology\| PubMed ID: 24452146	2013
An updated review of gastric cancer in the next-generation sequencing era: insights from bench to bedside and vice versa. World journal of gastroenterology\| PubMed ID: 24744582	2014
Chromatin regulators in neurodevelopment and disease: Analysis of fly neural circuits provides insights: Networks of chromatin regulators and transcription factors underlie Drosophila neurog... BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 25067789	2014
[Successful treatment with a combination of lenalidomide and dexamethasone for cryoglobulinemia associated with multiple myeloma]. [Rinshō ketsueki] The Japanese journal of clinical hematology\| PubMed ID: 25186485	2014
Treatment outcome of elderly patients with aggressive adult T cell leukemia-lymphoma: Nagasaki University Hospital experience. International journal of hematology\| PubMed ID: 25209605	2014
Heat shock protein 90 inhibitor NVP-AUY922 exerts potent activity against adult T-cell leukemia-lymphoma cells. Cancer science\| PubMed ID: 25263741	2014
Inhibitory mechanism of FAT4 gene expression in response to actin dynamics during Src-induced carcinogenesis. PloS one\| PubMed ID: 25679223	2015
Constitutive activation of Drosophila CncC transcription factor reduces lipid formation in the fat body. Biochemical and biophysical research communications\| PubMed ID: 26049108	2015
Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein. Cancer research\| PubMed ID: 26130649	2015
Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation. Scientific reports\| PubMed ID: 26412716	2015
CCR4 frameshift mutation identifies a distinct group of adult T cell leukaemia/lymphoma with poor prognosis. The Journal of pathology\| PubMed ID: 26847489	2016
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. Nature genetics\| PubMed ID: 27064257	2016
Induction of apoptosis by HBI-8000 in adult T-cell leukemia/lymphoma is associated with activation of Bim and NLRP3. Cancer science\| PubMed ID: 27193821	2016
Adult T-cell leukemia/lymphoma in donor cells responding to second allogeneic hematopoietic stem cell transplantation using unrelated cord blood: the Nagasaki Transplant Group experience. Leukemia & lymphoma\| PubMed ID: 27210445	2016
Systematic analysis of mutation distribution in three dimensional protein structures identifies cancer driver genes. Scientific reports\| PubMed ID: 27225414	2016
Erratum: Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. Nature genetics\| PubMed ID: 27230686	2016
USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting the proteasome gene expression. Biochemical and biophysical research communications\| PubMed ID: 27416755	2016
PD-L1 expression on neoplastic or stromal cells is respectively a poor or good prognostic factor for adult T-cell leukemia/lymphoma. Blood\| PubMed ID: 27418641	2016
Fluorescence multispectral imaging-based diagnostic system for atherosclerosis. Biomedical engineering online\| PubMed ID: 27542354	2016
Cancer stem cells in human gastrointestinal cancer. Cancer science\| PubMed ID: 27575869	2016
Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes. Biochemical and biophysical research communications\| PubMed ID: 28088524	2017
Influence of Single-Nucleotide Polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the Changes in Anthropometric Indices and Blood Measurements through Exercise-Centered Lifestyle Intervention in... International journal of molecular sciences\| PubMed ID: 29494521	2018
Manipulating Living Cells to Construct a 3D Single-Cell Assembly without an Artificial Scaffold. Polymers\| PubMed ID: 30970994	2017