Charles C. Richardson

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 13	2010
Publication title Cited by 3	2017

Other Publications

Article	Year
Lagging strand synthesis in coordinated DNA synthesis by bacteriophage t7 replication proteins. Journal of molecular biology\| PubMed ID: 11829500	2002
Interaction of adjacent primase domains within the hexameric gene 4 helicase-primase of bacteriophage T7. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12228732	2002
Essential amino acid residues in the single-stranded DNA-binding protein of bacteriophage T7. Identification of the dimer interface. The Journal of biological chemistry\| PubMed ID: 12379653	2002
The DNA binding domain of the gene 2.5 single-stranded DNA-binding protein of bacteriophage T7. The Journal of biological chemistry\| PubMed ID: 12496273	2003
A covalent linkage between the gene 5 DNA polymerase of bacteriophage T7 and Escherichia coli thioredoxin, the processivity factor: fate of thioredoxin during DNA synthesis. The Journal of biological chemistry\| PubMed ID: 12692131	2003
A single-stranded DNA-binding protein of bacteriophage T7 defective in DNA annealing. The Journal of biological chemistry\| PubMed ID: 12748198	2003
The carboxyl-terminal domain of bacteriophage T7 single-stranded DNA-binding protein modulates DNA binding and interaction with T7 DNA polymerase. The Journal of biological chemistry\| PubMed ID: 12766155	2003
Modular architecture of the bacteriophage T7 primase couples RNA primer synthesis to DNA synthesis. Molecular cell\| PubMed ID: 12769857	2003
Single-molecule kinetics of lambda exonuclease reveal base dependence and dynamic disorder. Science (New York, N.Y.)\| PubMed ID: 12947199	2003
Proteomic analysis of thioredoxin-targeted proteins in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15004283	2004
Effect of single-stranded DNA-binding proteins on the helicase and primase activities of the bacteriophage T7 gene 4 protein. The Journal of biological chemistry\| PubMed ID: 15044449	2004
The linker region between the helicase and primase domains of the gene 4 protein of bacteriophage T7. Role in helicase conformation and activity. The Journal of biological chemistry\| PubMed ID: 15044475	2004
The arginine finger of bacteriophage T7 gene 4 helicase: role in energy coupling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15070725	2004
A unique region in bacteriophage t7 DNA polymerase important for exonucleolytic hydrolysis of DNA. The Journal of biological chemistry\| PubMed ID: 15292168	2004
The highly processive DNA polymerase of bacteriophage T5. Role of the unique N and C termini. The Journal of biological chemistry\| PubMed ID: 15377656	2004
Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15528277	2004
A unique loop in T7 DNA polymerase mediates the binding of helicase-primase, DNA binding protein, and processivity factor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15795374	2005
Acidic residues in the nucleotide-binding site of the bacteriophage T7 DNA primase. The Journal of biological chemistry\| PubMed ID: 15917241	2005
DNA-induced switch from independent to sequential dTTP hydrolysis in the bacteriophage T7 DNA helicase. Molecular cell\| PubMed ID: 16427007	2006
DNA primase acts as a molecular brake in DNA replication. Nature\| PubMed ID: 16452983	2006
Primer initiation and extension by T7 DNA primase. The EMBO journal\| PubMed ID: 16642036	2006
Oligomeric states of bacteriophage T7 gene 4 primase/helicase. Journal of molecular biology\| PubMed ID: 16777142	2006
The C-terminal residues of bacteriophage T7 gene 4 helicase-primase coordinate helicase and DNA polymerase activities. The Journal of biological chemistry\| PubMed ID: 16807231	2006
Essential residues in the C terminus of the bacteriophage T7 gene 2.5 single-stranded DNA-binding protein. The Journal of biological chemistry\| PubMed ID: 16807232	2006
Single molecule force spectroscopy of salt-dependent bacteriophage T7 gene 2.5 protein binding to single-stranded DNA. The Journal of biological chemistry\| PubMed ID: 17050544	2006
Genomewide screens for Escherichia coli genes affecting growth of T7 bacteriophage. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17135349	2006
Exchange of DNA polymerases at the replication fork of bacteriophage T7. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17369350	2007
Dynamic DNA helicase-DNA polymerase interactions assure processive replication fork movement. Molecular cell\| PubMed ID: 17707227	2007
Inadequate inhibition of host RNA polymerase restricts T7 bacteriophage growth on hosts overexpressing udk. Molecular microbiology\| PubMed ID: 18067538	2008
Acidic C-terminal tail of the ssDNA-binding protein of bacteriophage T7 and ssDNA compete for the same binding surface. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18238893	2008
Communication between subunits critical to DNA binding by hexameric helicase of bacteriophage T7. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18574147	2008
Gene 1.7 of bacteriophage T7 confers sensitivity of phage growth to dideoxythymidine. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18599435	2008
Peptide ligands specific to the oxidized form of Escherichia coli thioredoxin. Biochimica et biophysica acta\| PubMed ID: 18672101	2008
Interactions of Escherichia coli thioredoxin, the processivity factor, with bacteriophage T7 DNA polymerase and helicase. The Journal of biological chemistry\| PubMed ID: 18757858	2008
Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis. Nature\| PubMed ID: 19029884	2009
DNA recognition by the DNA primase of bacteriophage T7: a structure-function study of the zinc-binding domain. Biochemistry\| PubMed ID: 19206208	2009
Promiscuous usage of nucleotides by the DNA helicase of bacteriophage T7: determinants of nucleotide specificity. The Journal of biological chemistry\| PubMed ID: 19297330	2009
Motors, switches, and contacts in the replisome. Annual review of biochemistry\| PubMed ID: 19298182	2009
Mutations in the gene 5 DNA polymerase of bacteriophage T7 suppress the dominant lethal phenotype of gene 2.5 ssDNA binding protein lacking the C-terminal phenylalanine. Molecular microbiology\| PubMed ID: 19400798	2009
Rescue of bacteriophage T7 DNA polymerase of low processivity by suppressor mutations affecting gene 3 endonuclease. Journal of virology\| PubMed ID: 19535436	2009
An in trans interaction at the interface of the helicase and primase domains of the hexameric gene 4 protein of bacteriophage T7 modulates their activities. The Journal of biological chemistry\| PubMed ID: 19574219	2009
C-terminal phenylalanine of bacteriophage T7 single-stranded DNA-binding protein is essential for strand displacement synthesis by T7 DNA polymerase at a nick in DNA. The Journal of biological chemistry\| PubMed ID: 19726688	2009
Thioredoxin suppresses microscopic hopping of T7 DNA polymerase on duplex DNA. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20080681	2010
Mechanism of sequence-specific template binding by the DNA primase of bacteriophage T7. Nucleic acids research\| PubMed ID: 20350931	2010
Residues in the central beta-hairpin of the DNA helicase of bacteriophage T7 are important in DNA unwinding. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20351255	2010
Two modes of interaction of the single-stranded DNA-binding protein of bacteriophage T7 with the DNA polymerase-thioredoxin complex. The Journal of biological chemistry\| PubMed ID: 20375019	2010
Direct role for the RNA polymerase domain of T7 primase in primer delivery. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20439755	2010
A novel nucleotide kinase encoded by gene 1.7 of bacteriophage T7. Molecular microbiology\| PubMed ID: 20497505	2010
Molecular basis for recognition of nucleoside triphosphate by gene 4 helicase of bacteriophage T7. The Journal of biological chemistry\| PubMed ID: 20688917	2010
Conformational dynamics of bacteriophage T7 DNA polymerase and its processivity factor, Escherichia coli thioredoxin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20696935	2010
Simultaneous single-molecule measurements of phage T7 replisome composition and function reveal the mechanism of polymerase exchange. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21245349	2011
The glutamate switch of bacteriophage T7 DNA helicase: role in coupling nucleotide triphosphate (NTP) and DNA binding to NTP hydrolysis. The Journal of biological chemistry\| PubMed ID: 21566126	2011
Helicase-DNA polymerase interaction is critical to initiate leading-strand DNA synthesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21606333	2011
Pyrovanadolysis, a pyrophosphorolysis-like reaction mediated by pyrovanadate, Mn2+, and DNA polymerase of bacteriophage T7. The Journal of biological chemistry\| PubMed ID: 21697085	2011
Bypass of a nick by the replisome of bacteriophage T7. The Journal of biological chemistry\| PubMed ID: 21701044	2011
Coupling dTTP hydrolysis with DNA unwinding by the DNA helicase of bacteriophage T7. The Journal of biological chemistry\| PubMed ID: 21840995	2011
Choreography of bacteriophage T7 DNA replication. Current opinion in chemical biology\| PubMed ID: 21907611	2011
Essential protein interactions within the replisome regulate DNA replication. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22067709	2011