Jeffrey C. Edberg

Department of Medicine, University of Alabama at Birmingham

Affiliated withUniversity of Alabama at Birmingham

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 12	2014

Other Publications

Article	Year
Differential Regulation of Fcgamma Receptor Isoforms: Implications for Therapeutic Intervention. American journal of therapeutics\| PubMed ID: 11854786	1995
The CY domain of the Fcgamma RIa alpha-chain (CD64) alters gamma-chain tyrosine-based signaling and phagocytosis. The Journal of biological chemistry\| PubMed ID: 12200451	2002
Genetic linkage and association of Fcgamma receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus. Arthritis and rheumatism\| PubMed ID: 12209518	2002
Diversity and duplicity: human FCgamma receptors in host defense and autoimmunity. Immunologic research\| PubMed ID: 12403356	2002
A novel polymorphic CAAT/enhancer-binding protein beta element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythema... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12496392	2003
A novel polymorphism in the Fcgamma receptor IIB (CD32B) transmembrane region alters receptor signaling. Arthritis and rheumatism\| PubMed ID: 14613290	2003
Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14634123	2003
A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15153543	2004
A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. II. Differential binding of GATA4 ... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15153544	2004
The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. Arthritis and rheumatism\| PubMed ID: 15457442	2004
Differential gene expression modulated by the cytoplasmic domain of Fc gamma RIa (CD64) alpha-chain. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15528358	2004
Time to renal disease and end-stage renal disease in PROFILE: a multiethnic lupus cohort. PLoS medicine\| PubMed ID: 17076550	2006
Association of a transmembrane polymorphism of Fcgamma receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients. Arthritis and rheumatism\| PubMed ID: 17133600	2006
Anti-GD3 monoclonal antibody effects on lymphocytes and antibody-dependent cellular cytotoxicity. Cancer biotherapy & radiopharmaceuticals\| PubMed ID: 17257070	2006
Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosus. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17312177	2007
FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17339498	2007
Clinical and genetic risk factors for pneumonia in systemic lupus erythematosus. Arthritis and rheumatism\| PubMed ID: 17665457	2007
Variation in the relative copy number of the TLR7 gene in patients with systemic lupus erythematosus and healthy control subjects. Arthritis and rheumatism\| PubMed ID: 17907191	2007
Fc receptor genes and the systemic lupus erythematosus diathesis. Autoimmunity\| PubMed ID: 18075791	2007
IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1. The Journal of clinical investigation\| PubMed ID: 18172551	2008
Genetic variation in the CRP promoter: association with systemic lupus erythematosus. Human molecular genetics\| PubMed ID: 18182444	2008
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nature genetics\| PubMed ID: 18204446	2008
Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18606652	2008
Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort. Arthritis and rheumatism\| PubMed ID: 18759263	2008
Functional expression of IgA receptor FcalphaRI on human platelets. Journal of leukocyte biology\| PubMed ID: 18784345	2008
An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans. PLoS genetics\| PubMed ID: 19300490	2009
Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus. Arthritis and rheumatism\| PubMed ID: 19333917	2009
Wegener's granulomatosis: a model of auto-antibodies in mucosal autoimmunity. Clinical immunology (Orlando, Fla.)\| PubMed ID: 19482554	2010
A polymorphism within IL21R confers risk for systemic lupus erythematosus. Arthritis and rheumatism\| PubMed ID: 19644854	2009
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nature genetics\| PubMed ID: 19838195	2009
The FCRL3-169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+ B ce... Arthritis and rheumatism\| PubMed ID: 19877046	2009
ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry. Annals of the rheumatic diseases\| PubMed ID: 19939855	2010
Retraction: an African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans. PLoS genetics\| PubMed ID: 20020059	2009
Pathways: Strategies for susceptibility genes in SLE. Autoimmunity reviews\| PubMed ID: 20144911	2010
Variations in CCL3L gene cluster sequence and non-specific gene copy numbers. BMC research notes\| PubMed ID: 20233400	2010
Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans. Annals of the rheumatic diseases\| PubMed ID: 20237121	2010
The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans. American journal of nephrology\| PubMed ID: 20523037	2010
The role of genetic variation near interferon-kappa in systemic lupus erythematosus. Journal of biomedicine & biotechnology\| PubMed ID: 20706608	2010
Alpha₁-antitrypsin deficiency-related alleles Z and S and the risk of Wegener's granulomatosis. Arthritis and rheumatism\| PubMed ID: 20827781	2010
A higher degree of methylation of the HPV 16 E6 gene is associated with a lower likelihood of being diagnosed with cervical intraepithelial neoplasia. Cancer\| PubMed ID: 20945322	2011
Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans. Arthritis and rheumatism\| PubMed ID: 21120996	2010
Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study. American journal of human genetics\| PubMed ID: 21194677	2011
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nature genetics\| PubMed ID: 21336280	2011
Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21. Arthritis and rheumatism\| PubMed ID: 21425124	2011
Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus. Arthritis and rheumatism\| PubMed ID: 21437871	2011
A higher degree of LINE-1 methylation in peripheral blood mononuclear cells, a one-carbon nutrient related epigenetic alteration, is associated with a lower risk of developing cervical intra... Nutrition (Burbank, Los Angeles County, Calif.)\| PubMed ID: 21463750	2011
Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups. Arthritis and rheumatism\| PubMed ID: 21590681	2011
Functional FCGR2B gene variants influence intravenous immunoglobulin response in patients with Kawasaki disease. The Journal of allergy and clinical immunology\| PubMed ID: 21601260	2011
Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. PLoS genetics\| PubMed ID: 21637784	2011
Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Annals of the rheumatic diseases\| PubMed ID: 21719445	2011
Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study. Arthritis and rheumatism\| PubMed ID: 21792837	2011
FAS mRNA editing in Human Systemic Lupus Erythematosus. Human mutation\| PubMed ID: 21793106	2011
Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus. Arthritis and rheumatism\| PubMed ID: 21952918	2012
Serine phosphorylation of FcγRI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1G. Journal of leukocyte biology\| PubMed ID: 22003208	2012
Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions. PloS one\| PubMed ID: 22022540	2011
IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematos... Annals of the rheumatic diseases\| PubMed ID: 22088620	2012
Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus. Annals of the rheumatic diseases\| PubMed ID: 22110124	2012
Association of single-nucleotide polymorphisms in CCR6, TAGAP, and TNFAIP3 with rheumatoid arthritis in African Americans. Arthritis and rheumatism\| PubMed ID: 22127930	2012
IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22147912	2011
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. American journal of human genetics\| PubMed ID: 22464253	2012
Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis. Arthritis and rheumatism\| PubMed ID: 22508400	2012
Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries. Annals of the rheumatic diseases\| PubMed ID: 22523428	2012
Role of activating FcγR gene polymorphisms in Kawasaki disease susceptibility and intravenous immunoglobulin response. Circulation. Cardiovascular genetics\| PubMed ID: 22565545	2012
A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed. Vaccine\| PubMed ID: 22658931	2012
Genetic risk factors for thrombosis in systemic lupus erythematosus. The Journal of rheumatology\| PubMed ID: 22707612	2012
Two independent functional risk haplotypes in TNIP1 are associated with systemic lupus erythematosus. Arthritis and rheumatism\| PubMed ID: 22833143	2012
Impact of genetic ancestry and socio-demographic status on the clinical expression of systemic lupus erythematosus in Amerindian-European populations. Arthritis and rheumatism\| PubMed ID: 22886787	2012
Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Annals of the rheumatic diseases\| PubMed ID: 22904263	2012
The unique cytoplasmic domain of human FcγRIIIA regulates receptor-mediated function. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23024279	2012
Brief Report: Single-nucleotide polymorphisms in VKORC1 are risk factors for systemic lupus erythematosus in Asians. Arthritis and rheumatism\| PubMed ID: 23124848	2013
Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS genetics\| PubMed ID: 23441136	2013
MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS genetics\| PubMed ID: 23468661	2013
Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry. The Journal of rheumatology\| PubMed ID: 23637325	2013
Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis. Arthritis and rheumatism\| PubMed ID: 23740775	2013
Genomic copy number variants: evidence for association with antibody response to anthrax vaccine adsorbed. PloS one\| PubMed ID: 23741398	2013
FcγR gene copy number in Kawasaki disease and intravenous immunoglobulin treatment response. Pharmacogenetics and genomics\| PubMed ID: 23778324	2013
Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils. Arthritis and rheumatism\| PubMed ID: 23918739	2013
PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes. PloS one\| PubMed ID: 23950893	2013
ABIN1 Dysfunction as a Genetic Basis for Lupus Nephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 23970121	2013
Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression. PLoS genetics\| PubMed ID: 24130510	2013
Allelic-dependent expression of an activating Fc receptor on B cells enhances humoral immune responses. Science translational medicine\| PubMed ID: 24353158	2013
FcγRIIIa SNPs and haplotypes affect human IgG binding and association with lupus nephritis in African Americans. Arthritis and rheumatism\| PubMed ID: 24375423	2013
End-stage renal disease in African Americans with lupus nephritis is associated with APOL1. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24504811	2014
A polymorphism in TLR2 is associated with arterial thrombosis in a multi-ethnic SLE population. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24578102	2014
Fcγ receptor IIIa single-nucleotide polymorphisms and haplotypes affect human IgG binding and are associated with lupus nephritis in African Americans. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24782186	2014
Lupus Nephritis Susceptibility Loci in Women with Systemic Lupus Erythematosus. Journal of the American Society of Nephrology : JASN\| PubMed ID: 24925725	2014