Tommy Alain

Goodman Cancer Centre and Department of Biochemistry, McGill University

Research Area

Biography

Tommy Alain has not added Biography.
If you are Tommy Alain and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 216	2014

Other Publications

Article	Year
Oncolytic reovirus against ovarian and colon cancer. Cancer research\| PubMed ID: 11912142	2002
Reovirus therapy of lymphoid malignancies. Blood\| PubMed ID: 12393565	2002
Lymphomas and oncolytic virus therapy. Clinical lymphoma\| PubMed ID: 14556682	2003
Stromelysin-2 (matrix metalloproteinase 10) is inducible in lymphoma cells and accelerates the growth of lymphoid tumors in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15356104	2004
Myxoma virus is a novel oncolytic virus with significant antitumor activity against experimental human gliomas. Cancer research\| PubMed ID: 16267023	2005
Effects of intravenously administered recombinant vesicular stomatitis virus (VSV(deltaM51)) on multifocal and invasive gliomas. Journal of the National Cancer Institute\| PubMed ID: 17077357	2006
Proteolytic disassembly is a critical determinant for reovirus oncolysis. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17519890	2007
Targeting human medulloblastoma: oncolytic virotherapy with myxoma virus is enhanced by rapamycin. Cancer research\| PubMed ID: 17875723	2007
Susceptibility of mantle cell lymphomas to reovirus oncolysis. Leukemia research\| PubMed ID: 19651440	2010
Transcription factors down-stream of Ras as molecular indicators for targeting malignancies with oncolytic herpes virus. Molecular oncology\| PubMed ID: 19766068	2009
p53-dependent translational control of senescence and transformation via 4E-BPs. Cancer cell\| PubMed ID: 19878875	2009
The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20018725	2009
Myxoma virus virotherapy for glioma in immunocompetent animal models: optimizing administration routes and synergy with rapamycin. Cancer research\| PubMed ID: 20068158	2010
Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20080710	2010
Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing. Nucleic acids research\| PubMed ID: 20413581	2010
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science (New York, N.Y.)\| PubMed ID: 20508131	2010
Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), ... The Journal of biological chemistry\| PubMed ID: 21659537	2011
Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death. Cancer cell\| PubMed ID: 22014571	2011
IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22447977	2012
Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. The Journal of biological chemistry\| PubMed ID: 22474287	2012
Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E. Nature immunology\| PubMed ID: 22544393	2012
Distinct perturbation of the translatome by the antidiabetic drug metformin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22611195	2012
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Molecular and cellular biology\| PubMed ID: 22751931	2012
eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies. Cancer research\| PubMed ID: 23100465	2012
mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio. Oncotarget\| PubMed ID: 23455427	2012
Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex. Molecular and cellular biology\| PubMed ID: 23608534	2013
Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q. PLoS biology\| PubMed ID: 23700384	2013
Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling. Neuron\| PubMed ID: 23972597	2013
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell metabolism\| PubMed ID: 24206664	2013
Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase. Molecular and cellular biology\| PubMed ID: 24396066	2014
Multifaceted regulation of somatic cell reprogramming by mRNA translational control. Cell stem cell\| PubMed ID: 24630793	2014