David M. Nanus

Department of Medicine, Weill Cornell Medical College

Affiliated withWeill Cornell Medical College

Research Area

Biography

David M. Nanus has not added Biography.
If you are David M. Nanus and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2014

Other Publications

Article	Year
Synergy in tumor suppression by direct interaction of neutral endopeptidase with PTEN. Cancer cell\| PubMed ID: 14749127	2004
Aminopeptidase A is a functional target in angiogenic blood vessels. Cancer cell\| PubMed ID: 14998491	2004
Active chemotherapy for collecting duct carcinoma of the kidney: a case report and review of the literature. Cancer\| PubMed ID: 11815966	2002
Retinol metabolism and lecithin:retinol acyltransferase levels are reduced in cultured human prostate cancer cells and tissue specimens. Cancer research\| PubMed ID: 11912136	2002
Synergistic activation of the androgen receptor by bombesin and low-dose androgen. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 12114445	2002
Estramustine plus a taxane for advanced prostate cancer: the new standard therapy? Cancer investigation\| PubMed ID: 12197243	2002
The utility of monoclonal antibodies in the imaging of prostate cancer. Seminars in urologic oncology\| PubMed ID: 12215974	2002
Phase I trial of interferon alpha2b and liposome-encapsulated all-trans retinoic acid in the treatment of patients with advanced renal cell carcinoma. Cancer\| PubMed ID: 12216088	2002
High expression of the Met receptor in prostate cancer metastasis to bone. Urology\| PubMed ID: 12475693	2002
Detection of the p110 beta subunit of phosphatidylinositol 3-kinase complexed with neutral endopeptidase. Anticancer research\| PubMed ID: 12529960	2002
Chemotherapeutic strategies for renal cell carcinoma. The Urologic clinics of North America\| PubMed ID: 12953758	2003
Targeting metastatic prostate cancer with radiolabeled monoclonal antibody J591 to the extracellular domain of prostate specific membrane antigen. The Journal of urology\| PubMed ID: 14532761	2003
Targeted systemic therapy of prostate cancer with a monoclonal antibody to prostate-specific membrane antigen. Seminars in oncology\| PubMed ID: 14571414	2003
Differential expression of the enzyme that esterifies retinol, lecithin:retinol acyltransferase, in subtypes of human renal cancer and normal kidney. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 14581364	2003
Third international conference on innovations and challenges in prostate cancer: prevention, detection and treatment. The Journal of urology\| PubMed ID: 14610403	2003
Clinical use of monoclonal antibody HuJ591 therapy: targeting prostate specific membrane antigen. The Journal of urology\| PubMed ID: 14610416	2003
Of peptides and peptidases: the role of cell surface peptidases in cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 14695128	2003
Direct binding of neutral endopeptidase 24.11 to ezrin/radixin/moesin (ERM) proteins competes with the interaction of CD44 with ERM proteins. The Journal of biological chemistry\| PubMed ID: 14704146	2004
Chemosensitization of androgen-independent prostate cancer with neutral endopeptidase. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 14734478	2004
Reduced lecithin: retinol acyltransferase expression correlates with increased pathologic tumor stage in bladder cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15161698	2004
Phase I trial of yttrium-90-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for androgen-independent prostate cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 15173215	2004
Neutral endopeptidase protein expression and prognosis in localized prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15217945	2004
Active chemotherapy for sarcomatoid and rapidly progressing renal cell carcinoma. Cancer\| PubMed ID: 15378501	2004
Retinoid receptor mRNA expression profiles in human bladder cancer specimens. International journal of oncology\| PubMed ID: 15754000	2005
Pharmacokinetics and biodistribution of 111In- and 177Lu-labeled J591 antibody specific for prostate-specific membrane antigen: prediction of 90Y-J591 radiation dosimetry based on 111In or 1... Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 15809486	2005
Phase I trial of 177lutetium-labeled J591, a monoclonal antibody to prostate-specific membrane antigen, in patients with androgen-independent prostate cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 15837970	2005
Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15867260	2005
Prediction of myelotoxicity based on bone marrow radiation-absorbed dose: radioimmunotherapy studies using 90Y- and 177Lu-labeled J591 antibodies specific for prostate-specific membrane anti... Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 15872360	2005
Involvement of neutral endopeptidase in neoplastic progression. Biochimica et biophysica acta\| PubMed ID: 16054017	2005
Radioimmunotherapy of prostate cancer using 90Y- and 177Lu-labeled J591 monoclonal antibodies: effect of multiple treatments on myelotoxicity. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16203821	2005
Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma. Carcinogenesis\| PubMed ID: 16344273	2006
Antibody-based therapeutics: focus on prostate cancer. Cancer metastasis reviews\| PubMed ID: 16408160	2005
Clinical utility of radiolabeled monoclonal antibodies in prostate cancer. Clinical genitourinary cancer\| PubMed ID: 16729907	2006
Chemotherapy for non-clear-cell renal cell carcinoma. Clinical genitourinary cancer\| PubMed ID: 16729909	2006
Neprilysin inhibits angiogenesis via proteolysis of fibroblast growth factor-2. The Journal of biological chemistry\| PubMed ID: 16940054	2006
Multiple androgen response elements cooperate in androgen regulated activity of the type 1 neutral endopeptidase promoter. Molecular and cellular endocrinology\| PubMed ID: 16949732	2006
Increased serum leptin levels and over expression of leptin receptors are associated with the invasion and progression of renal cell carcinoma. The Journal of urology\| PubMed ID: 16952705	2006
Leptin promotes invasiveness of murine renal cancer cells via extracellular signal-regulated kinases and rho dependent pathway. The Journal of urology\| PubMed ID: 16952706	2006
Loss of neutral endopeptidase and activation of protein kinase B (Akt) is associated with prostate cancer progression. Cancer\| PubMed ID: 17083125	2006
Clinical relevance of neutral endopeptidase (NEP/CD10) in melanoma. Journal of translational medicine\| PubMed ID: 17207277	2007
Vascular targeted therapy with anti-prostate-specific membrane antigen monoclonal antibody J591 in advanced solid tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 17290063	2007
Trastuzumab, paclitaxel, carboplatin, and gemcitabine in advanced human epidermal growth factor receptor-2/neu-positive urothelial carcinoma: results of a multicenter phase II National Cance... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 17538166	2007
Bombesin attenuates pre-mRNA splicing of glucocorticoid receptor by regulating the expression of serine-arginine protein p30c (SRp30c) in prostate cancer cells. Biochimica et biophysica acta\| PubMed ID: 17540466	2007
Low incidence of perioperative chemotherapy for stage III bladder cancer 1998 to 2003: a report from the National Cancer Data Base. The Journal of urology\| PubMed ID: 17561135	2007
Phase 1/2 clinical trial of interferon alpha2b and weekly liposome-encapsulated all-trans retinoic acid in patients with advanced renal cell carcinoma. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 17667529	2007
Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2. International journal of oncology\| PubMed ID: 17912448	2007
Inactivation of the NF2 tumor suppressor protein merlin in DU145 prostate cancer cells. The Prostate\| PubMed ID: 18361411	2008
Endothelin-1 enhances the expression of the androgen receptor via activation of the c-myc pathway in prostate cancer cells. Molecular carcinogenesis\| PubMed ID: 18623111	2009
A phase II study of estramustine, docetaxel, and exisulind in patients with hormone- refractory prostate cancer: results of cancer and leukemia group B trial 90004. Clinical genitourinary cancer\| PubMed ID: 18824434	2008
Surveillance of urothelial carcinoma: stage and grade migration, 1993-2005 and survival trends, 1993-2000. Cancer\| PubMed ID: 19215030	2009
Rational redesign of neutral endopeptidase binding to merlin and moesin proteins. Protein science : a publication of the Protein Society\| PubMed ID: 19388049	2009
Retinoid metabolism and ALDH1A2 (RALDH2) expression are altered in the transgenic adenocarcinoma mouse prostate model. Biochemical pharmacology\| PubMed ID: 19549509	2009
Final results of sequential doxorubicin plus gemcitabine and ifosfamide, paclitaxel, and cisplatin chemotherapy in patients with metastatic or locally advanced transitional cell carcinoma of... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 19636012	2009
Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19657023	2009
Neutral endopeptidase is a myristoylated protein. Molecular and cellular biochemistry\| PubMed ID: 19756956	2010
Carcinomatous meningitis in a patient with Her2/neu expressing bladder cancer following trastuzumab and chemotherapy: a case report and review of the literature. Journal of medical case reports\| PubMed ID: 19918289	2009
Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody. Lab on a chip\| PubMed ID: 20024046	2010
Is methylation the key to CD10 loss? Journal of pediatric hematology/oncology\| PubMed ID: 20051779	2010
Anti-prostate-specific membrane antigen-based radioimmunotherapy for prostate cancer. Cancer\| PubMed ID: 20127956	2010
Phase I trial of ATRA-IV and Depakote in patients with advanced solid tumor malignancies. Cancer biology & therapy\| PubMed ID: 20200483	2010
Carboplatin plus paclitaxel therapy after docetaxel in men with metastatic castrate resistant prostate cancer. Urologic oncology\| PubMed ID: 20451413	2011
A phase I trial of sorafenib plus gemcitabine and capecitabine for patients with advanced renal cell carcinoma: New York Cancer Consortium Trial NCI 6981. American journal of clinical oncology\| PubMed ID: 20881475	2011
Recent advances in management of renal cancer. F1000 medicine reports\| PubMed ID: 20948687	2009
Transitional cell carcinoma of the bladder: racial and gender disparities in survival (1993 to 2002), stage and grade (1993 to 2007). The Journal of urology\| PubMed ID: 21419456	2011
Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer. Cancer research\| PubMed ID: 21799031	2011
Generation of a mouse model of Von Hippel-Lindau kidney disease leading to renal cancers by expression of a constitutively active mutant of HIF1α. Cancer research\| PubMed ID: 21908555	2011
Biomarkers in the management and treatment of men with metastatic castration-resistant prostate cancer. European urology\| PubMed ID: 22099611	2012
Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets. Cancer discovery\| PubMed ID: 22389870	2011
Functional characterization of circulating tumor cells with a prostate-cancer-specific microfluidic device. PloS one\| PubMed ID: 22558290	2012
Adenoviral neutral endopeptidase gene delivery in combination with paclitaxel for the treatment of prostate cancer. International journal of oncology\| PubMed ID: 22895534	2012
Targeted next-generation sequencing of advanced prostate cancer identifies potential therapeutic targets and disease heterogeneity. European urology\| PubMed ID: 22981675	2013
Androgen receptor on the move: boarding the microtubule expressway to the nucleus. Cancer research\| PubMed ID: 22987486	2012
Isolation and characterization of circulating tumor cells in prostate cancer. Frontiers in oncology\| PubMed ID: 23087897	2012
Negative regulation of NEP expression by hypoxia. The Prostate\| PubMed ID: 23138928	2013
Challenges in recognizing treatment-related neuroendocrine prostate cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 23169519	2012
2-weekly versus 3-weekly docetaxel for prostate cancer. The lancet oncology\| PubMed ID: 23294852	2013
Concurrent AURKA and MYCN gene amplifications are harbingers of lethal treatment-related neuroendocrine prostate cancer. Neoplasia (New York, N.Y.)\| PubMed ID: 23358695	2013
Activation of HIF2α in kidney proximal tubule cells causes abnormal glycogen deposition but not tumorigenesis. Cancer research\| PubMed ID: 23447580	2013
Phase II study of Lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for metastatic castration-resistant prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23714732	2013
Bone marrow recovery and subsequent chemotherapy following radiolabeled anti-prostate-specific membrane antigen monoclonal antibody j591 in men with metastatic castration-resistant prostate ... Frontiers in oncology\| PubMed ID: 23986881	2013
Double-blind, randomized, phase 2 trial of maintenance sunitinib versus placebo after response to chemotherapy in patients with advanced urothelial carcinoma. Cancer\| PubMed ID: 24249435	2014
Circulating tumor cells from prostate cancer patients interact with E-selectin under physiologic blood flow. PloS one\| PubMed ID: 24386459	2013
Androgen receptor splice variants determine taxane sensitivity in prostate cancer. Cancer research\| PubMed ID: 24556717	2014
Immunologics and Chemotherapeutics for Renal Cell Carcinoma. Seminars in interventional radiology\| PubMed ID: 24596445	2014
Circulating Tumor Cells in Prostate Cancer Diagnosis and Monitoring: An Appraisal of Clinical Potential. Molecular diagnosis & therapy\| PubMed ID: 24809501	2014