quantification-global-diastolic-function-kinematic-modeling-based

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Quantitative cardiac function assessment remains a challenge for physiologists and clinicians.&#160;Although historically invasive methods have comprised ...

Washington University in St. Louis

-Heart failure with preserved ejection fraction (HFPEF) involves failure of cardiovascular reserve in multiple domains. In HFPEF animal models, dietary sodium restriction improves ventricular and vascular stiffness and function. We hypothesized that the sodium-restricted Dietary Approaches to Stop Hypertension diet (DASH/SRD) would improve left ventricular diastolic function, arterial elastance, and ventricular-arterial (V-A) coupling in hypertensive HFPEF.

Low-Sodium DASH Diet Improves Diastolic Function and Ventricular-Arterial Coupling in Hypertensive Heart Failure with Preserved Ejection Fraction.

Pseudonormal Doppler E-wave filling patterns indicate diastolic dysfunction but are indistinguishable from the normal filling pattern. For accurate classification, maneuvers to alter load or to additionally measure peak E' are required. E-wave deceleration time (DT) has been fractionated into its stiffness (DTs) and relaxation (DTr) components (DT=DTs+DTr) by analyzing E-waves via the parametrized diastolic filling formalism. The method has been validated with DTs and DTr correlating with simultaneous catheterization-derived stiffness (dP/dV) and relaxation (τ) with r=0.82 and r=0.94, respectively. We hypothesize that DT fractionation can (1) distinguish between unblinded (E' known) normal versus pseudonormal age-matched groups with normal left ventricular ejection fraction, and (2) distinguish between blinded (E' unknown) normal versus pseudonormal groups, based solely on E-wave analysis.

Article	Year
Low-Sodium DASH Diet Improves Diastolic Function and Ventricular-Arterial Coupling in Hypertensive Heart Failure with Preserved Ejection Fraction. Circulation. Heart failure\| PubMed ID: 23985432	2013
Fractionating e-wave deceleration time into its stiffness and relaxation components distinguishes pseudonormal from normal filling. Circulation. Cardiovascular imaging\| PubMed ID: 25596141	2015

Simeng Zhu

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