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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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1Department of Biomedical Engineering,Washington University in St. Louis, 2Department of Physics,Washington University in St. Louis, 3Division of Biology and Biomedical Sciences,Washington University in St. Louis, 4Department of Medicine, Cardiovascular Division,Washington University in St. Louis, 5Cardiovascular Biophysics Lab,Washington University in St. Louis
Chapters
- 00:05Title
- 02:33Conventional Analysis of E- and A-wave Properties
- 06:01Automated Fitting of Transmitral Flow Via the Parametrized Diastolic Filling (PDF) Formalism
- 08:20Results: Parametrized Diastolic Filling Model Fits to Representative Filling Patterns
- 09:33Conclusion
Accurate, causality-based quantification of global diastolic function has been achieved by kinematic modeling-based analysis of transmitral flow via the Parametrized Diastolic Filling (PDF) formalism. PDF generates unique stiffness, relaxation, and load parameters and elucidates 'new' physiology while providing sensitive and specific indexes of dysfunction.
