Howard Chen

Department of Biomedical Engineering, Washington University in St. Louis

Affiliated withWashington University in St. Louis Washington University in St. Louis

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2014

Other Publications

Article	Year
Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11867747	2002
The role of melanocortins in body weight regulation: opportunities for the treatment of obesity. European journal of pharmacology\| PubMed ID: 12007532	2002
Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Molecular and cellular biology\| PubMed ID: 12077332	2002
The role of melanocortins in body weight regulation: opportunities for the treatment of obesity. European journal of pharmacology\| PubMed ID: 12176114	2002
Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 12511609	2003
Effects of melanocortin receptor activation and blockade on ethanol intake: a possible role for the melanocortin-4 receptor. Alcoholism, clinical and experimental research\| PubMed ID: 15976520	2005
Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6... Bioorganic & medicinal chemistry letters\| PubMed ID: 15982875	2005
11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. The Journal of experimental medicine\| PubMed ID: 16103409	2005
Diet induction of monocyte chemoattractant protein-1 and its impact on obesity. Obesity research\| PubMed ID: 16129712	2005
Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. The Journal of biological chemistry\| PubMed ID: 16326714	2006
Sherrington innervational surgery in the treatment of chronic sixth nerve paresis. Binocular vision & strabismus quarterly\| PubMed ID: 16359278	2005
Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16954192	2006
Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity. Cell metabolism\| PubMed ID: 20096642	2010
Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists. Bioorganic & medicinal chemistry letters\| PubMed ID: 20167483	2010
Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist. Bioorganic & medicinal chemistry letters\| PubMed ID: 20207541	2010
Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands. Bioorganic & medicinal chemistry letters\| PubMed ID: 20598533	2010
Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity. Bioorganic & medicinal chemistry letters\| PubMed ID: 20598882	2010
Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists. Bioorganic & medicinal chemistry letters\| PubMed ID: 20621473	2010
Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity. Bioorganic & medicinal chemistry letters\| PubMed ID: 20933410	2010
Imaging of apoptosis in the heart with nanoparticle technology. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology\| PubMed ID: 20945336	2011
Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Bioorganic & medicinal chemistry letters\| PubMed ID: 21439820	2011
Protective effect of the apoptosis-sensing nanoparticle AnxCLIO-Cy5.5. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 21704591	2012
Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. The Journal of biological chemistry\| PubMed ID: 21775438	2011
Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium. Circulation. Cardiovascular imaging\| PubMed ID: 21836081	2011
Comparison of aneuploidies of chromosomes 21, X, and Y in the blood lymphocytes and sperm of workers exposed to benzene. Environmental and molecular mutagenesis\| PubMed ID: 22351378	2012
Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival. Theranostics\| PubMed ID: 22400062	2012
In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium. Journal of biomedical optics\| PubMed ID: 22612124	2012
Fluorochrome-functionalized magnetic nanoparticles for high-sensitivity monitoring of the polymerase chain reaction by magnetic resonance. Angewandte Chemie (International ed. in English)\| PubMed ID: 22684680	2012
Fiber architecture in remodeled myocardium revealed with a quantitative diffusion CMR tractography framework and histological validation. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance\| PubMed ID: 23061749	2012
Thrombotic thrombocytopenic purpura in pediatric patients. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics\| PubMed ID: 23146723	2012
Adult cardiac progenitor cell aggregates exhibit survival benefit both in vitro and in vivo. PloS one\| PubMed ID: 23226295	2012
Fluorochrome-functionalized nanoparticles for imaging DNA in biological systems. ACS nano\| PubMed ID: 23373524	2013
Characterization of printable cellular micro-fluidic channels for tissue engineering. Biofabrication\| PubMed ID: 23458889	2013
Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo. Circulation. Cardiovascular imaging\| PubMed ID: 23537953	2013
Molecular magnetic resonance imaging of pulmonary fibrosis in mice. American journal of respiratory cell and molecular biology\| PubMed ID: 23927643	2013
Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria. Chemical communications (Cambridge, England)\| PubMed ID: 24072060	2013
Role of extracellular RNA and TLR3-Trif signaling in myocardial ischemia-reperfusion injury. Journal of the American Heart Association\| PubMed ID: 24390148	2014
Microstructural impact of ischemia and bone marrow-derived cell therapy revealed with diffusion tensor magnetic resonance imaging tractography of the heart in vivo. Circulation\| PubMed ID: 24619466	2014
Direct coupling of annexin A5 to VSOP yields small, protein-covered nanoprobes for MR imaging of apoptosis. Contrast media & molecular imaging\| PubMed ID: 24706613	2014
Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. Science translational medicine\| PubMed ID: 25504881	2014
Cytoprotective nanoparticles by conjugation of a polyhis tagged annexin V to a nanoparticle drug. Nanoscale\| PubMed ID: 25572921	2015
A comparison of instrumentation methods to estimate thoracolumbar motion in field-based occupational studies. Applied ergonomics\| PubMed ID: 25683549	2015