David A. Boas

Optics Division, Massachusetts General Hospital and Harvard Medical School

Affiliated withMassachusetts General Hospital and Harvard Medical School

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 27	2011

Other Publications

Article	Year
Near-infrared spiroximetry: noninvasive measurements of venous saturation in piglets and human subjects. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 11744680	2002
Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nature medicine\| PubMed ID: 11821897	2002
Frontal lobe activation during object permanence: data from near-infrared spectroscopy. NeuroImage\| PubMed ID: 12202098	2002
Non-invasive neuroimaging using near-infrared light. Biological psychiatry\| PubMed ID: 12372658	2002
A quantitative comparison of simultaneous BOLD fMRI and NIRS recordings during functional brain activation. NeuroImage\| PubMed ID: 12377147	2002
Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation. Optics letters\| PubMed ID: 12656525	2003
Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters. NeuroImage\| PubMed ID: 12725763	2003
Fluorescence optical diffusion tomography. Applied optics\| PubMed ID: 12790460	2003
Robust inference of baseline optical properties of the human head with three-dimensional segmentation from magnetic resonance imaging. Applied optics\| PubMed ID: 12790461	2003
Optode positional calibration in diffuse optical tomography. Applied optics\| PubMed ID: 12790466	2003
Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulation. Physics in medicine and biology\| PubMed ID: 12812454	2003
Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex. Neuron\| PubMed ID: 12873390	2003
Tomographic optical breast imaging guided by three-dimensional mammography. Applied optics\| PubMed ID: 12962399	2003
Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging. Psychophysiology\| PubMed ID: 14570163	2003
Volumetric diffuse optical tomography of brain activity. Optics letters\| PubMed ID: 14587815	2003
Noninvasive measurement of neuronal activity with near-infrared optical imaging. NeuroImage\| PubMed ID: 14741675	2004
Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomography. Optics letters\| PubMed ID: 14759043	2004
Fluorescence optical diffusion tomography using multiple-frequency data. Journal of the Optical Society of America. A, Optics, image science, and vision\| PubMed ID: 15191186	2004
Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 15241182	2004
Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media. Optics letters\| PubMed ID: 15309848	2004
Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy. NeuroImage\| PubMed ID: 15501097	2004
Pronounced hypoperfusion during spreading depression in mouse cortex. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 15529018	2004
Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15734797	2005
Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging. Applied optics\| PubMed ID: 15813518	2005
Optimal linear inverse solution with multiple priors in diffuse optical tomography. Applied optics\| PubMed ID: 15813531	2005
Simulation study of magnetic resonance imaging-guided cortically constrained diffuse optical tomography of human brain function. Applied optics\| PubMed ID: 15813532	2005
Using near-infrared spectroscopy to assess neural activation during object processing in infants. Journal of biomedical optics\| PubMed ID: 15847576	2005
Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation. Journal of biomedical optics\| PubMed ID: 15847579	2005
Eigenvector-based spatial filtering for reduction of physiological interference in diffuse optical imaging. Journal of biomedical optics\| PubMed ID: 15847580	2005
Coregistered tomographic x-ray and optical breast imaging: initial results. Journal of biomedical optics\| PubMed ID: 15910106	2005
Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex. NeuroImage\| PubMed ID: 15925522	2005
Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin. NeuroImage\| PubMed ID: 16084112	2005
A haemodynamic response function model in spatio-temporal diffuse optical tomography. Physics in medicine and biology\| PubMed ID: 16177494	2005
Quantitative spectroscopic diffuse optical tomography of the breast guided by imperfect a priori structural information. Physics in medicine and biology\| PubMed ID: 16177522	2005
Dynamic physiological modeling for functional diffuse optical tomography. NeuroImage\| PubMed ID: 16242967	2006
Vasoconstrictive neurovascular coupling during focal ischemic depolarizations. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 16340958	2006
Fluorescence-lifetime-based tomography for turbid media. Optics letters\| PubMed ID: 16389827	2005
Physiological system identification with the Kalman filter in diffuse optical tomography. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention\| PubMed ID: 16686015	2005
Effective scattering coefficient of the cerebral spinal fluid in adult head models for diffuse optical imaging. Applied optics\| PubMed ID: 16799690	2006
Time-gated optical system for depth-resolved functional brain imaging. Journal of biomedical optics\| PubMed ID: 16965165	2006
Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 17033691	2007
Assessing infants' cortical response to speech using near-infrared spectroscopy. NeuroImage\| PubMed ID: 17045812	2007
Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging. Applied optics\| PubMed ID: 17068557	2006
Diffuse optical imaging of the whole head. Journal of biomedical optics\| PubMed ID: 17092156	2006
A multicompartment vascular model for inferring baseline and functional changes in cerebral oxygen metabolism and arterial dilation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 17200678	2007
Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imaging. Journal of biomedical optics\| PubMed ID: 17212541	2006
Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation. NeuroImage\| PubMed ID: 17222567	2007
Near-infrared spectroscopy measurement of the pulsatile component of cerebral blood flow and volume from arterial oscillations. Journal of biomedical optics\| PubMed ID: 17343508	2007
Comparison of simplified Monte Carlo simulation and diffusion approximation for the fluorescence signal from phantoms with typical mouse tissue optical properties. Applied optics\| PubMed ID: 17356611	2007
Assessment of infant brain development with frequency-domain near-infrared spectroscopy. Pediatric research\| PubMed ID: 17413855	2007
Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17442830	2007
Image reconstruction in optical tomography in the presence of coupling errors. Applied optics\| PubMed ID: 17446924	2007
Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia. Brain : a journal of neurology\| PubMed ID: 17468117	2007
Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography. Physics in medicine and biology\| PubMed ID: 17664563	2007
Optical imaging of phonological processing in two distinct orthographies. Experimental brain research. Experimentelle Hirnforschung. ExpÃ©rimentation cÃ©rÃ©brale\| PubMed ID: 17999056	2008
A vascular anatomical network model of the spatio-temporal response to brain activation. NeuroImage\| PubMed ID: 18289880	2008
Comparison of frequency-domain and time-domain fluorescence lifetime tomography. Optics letters\| PubMed ID: 18311295	2008
Mild induced hypertension improves blood flow and oxygen metabolism in transient focal cerebral ischemia. Stroke; a journal of cerebral circulation\| PubMed ID: 18340095	2008
Coupling between somatosensory evoked potentials and hemodynamic response in the rat. NeuroImage\| PubMed ID: 18420425	2008
Hemodynamic response to featural changes in the occipital and inferior temporal cortex in infants: a preliminary methodological exploration. Developmental science\| PubMed ID: 18466370	2008
Estimation and statistical bounds for three-dimensional polar shapes in diffuse optical tomography. IEEE transactions on medical imaging\| PubMed ID: 18541483	2008
Estimating cerebral oxygen metabolism from fMRI with a dynamic multicompartment Windkessel model. Human brain mapping\| PubMed ID: 18649348	2009
Assessing the future of diffuse optical imaging technologies for breast cancer management. Medical physics\| PubMed ID: 18649477	2008
A time domain fluorescence tomography system for small animal imaging. IEEE transactions on medical imaging\| PubMed ID: 18672432	2008
Oxygen advection and diffusion in a three- dimensional vascular anatomical network. Optics express\| PubMed ID: 18958033	2008
Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia. Journal of biomedical optics\| PubMed ID: 19021335	2008
Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system. Journal of biomedical optics\| PubMed ID: 19021399	2008
Direct estimation of evoked hemoglobin changes by multimodality fusion imaging. Journal of biomedical optics\| PubMed ID: 19021411	2008
Multi-photon microscopy with a low-cost and highly efficient Cr:LiCAF laser. Optics express\| PubMed ID: 19065223	2008
Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression. IEEE transactions on medical imaging\| PubMed ID: 19116186	2009
Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19118167	2008
Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation. Journal of neuroscience methods\| PubMed ID: 19121336	2009
Identifying cortical lateralization of speech processing in infants using near-infrared spectroscopy. Developmental neuropsychology\| PubMed ID: 19142766	2009
Fast optical signal not detected in awake behaving monkeys. NeuroImage\| PubMed ID: 19150500	2009
Study of neurovascular coupling in humans via simultaneous magnetoencephalography and diffuse optical imaging acquisition. NeuroImage\| PubMed ID: 19286463	2009
Simultaneous imaging of cerebral partial pressure of oxygen and blood flow during functional activation and cortical spreading depression. Applied optics\| PubMed ID: 19340106	2009
HomER: a review of time-series analysis methods for near-infrared spectroscopy of the brain. Applied optics\| PubMed ID: 19340120	2009
Intracranial microprobe for evaluating neuro-hemodynamic coupling in unanesthetized human neocortex. Journal of neuroscience methods\| PubMed ID: 19428529	2009
A cerebrovascular response model for functional neuroimaging including dynamic cerebral autoregulation. Mathematical biosciences\| PubMed ID: 19442671	2009
Time resolved fluorescence tomography of turbid media based on lifetime contrast. Optics express\| PubMed ID: 19529654	2006
Linear 3D reconstruction of time-domain diffuse optical imaging differential data: improved depth localization and lateral resolution. Optics express\| PubMed ID: 19550930	2007
Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast. Optics letters\| PubMed ID: 19572001	2009
Anatomical atlas-guided diffuse optical tomography of brain activation. NeuroImage\| PubMed ID: 19643185	2010
Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates' brains in the first six weeks of life. Human brain mapping\| PubMed ID: 19650140	2010
Increased cerebral blood volume and oxygen consumption in neonatal brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 19675563	2009
Sensitivity of neural-hemodynamic coupling to alterations in cerebral blood flow during hypercapnia. Journal of biomedical optics\| PubMed ID: 19725749	2009
Comment on 'Estimating a modified Grubb's exponent in healthy human brains with near infrared spectroscopy and transcranial Doppler'. Physiological measurement\| PubMed ID: 19767672	2009
Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography. Optics letters\| PubMed ID: 19838234	2009
Monte Carlo simulation of photon migration in 3D turbid media accelerated by graphics processing units. Optics express\| PubMed ID: 19997242	2009
The Possible Role of CO(2) in Producing A Post-Stimulus CBF and BOLD Undershoot. Frontiers in neuroenergetics\| PubMed ID: 20027233	2009
Optical monitoring of oxygen tension in cortical microvessels with confocal microscopy. Optics express\| PubMed ID: 20052157	2009
Dendritic phosphorescent probes for oxygen imaging in biological systems. ACS applied materials & interfaces\| PubMed ID: 20072726	2009
Perfusion pressure-dependent recovery of cortical spreading depression is independent of tissue oxygenation over a wide physiologic range. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 20087371	2010
Quantitative cerebral blood flow with optical coherence tomography. Optics express\| PubMed ID: 20174075	2010
Laser speckle contrast imaging in biomedical optics. Journal of biomedical optics\| PubMed ID: 20210435	2010
The effect of different anesthetics on neurovascular coupling. NeuroImage\| PubMed ID: 20350606	2010
Near-infrared spectroscopy shows right parietal specialization for number in pre-verbal infants. NeuroImage\| PubMed ID: 20561591	2010
Dissociation of processing of featural and spatiotemporal information in the infant cortex. NeuroImage\| PubMed ID: 20603218	2010
Rapid volumetric angiography of cortical microvasculature with optical coherence tomography. Optics letters\| PubMed ID: 20664667	2010
Examining the phonological neighborhood density effect using near infrared spectroscopy. Human brain mapping\| PubMed ID: 20690126	2011
Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nature methods\| PubMed ID: 20693997	2010
Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20696904	2010
Lifetime-based tomographic multiplexing. Journal of biomedical optics\| PubMed ID: 20799813	2010
Spontaneous low-frequency oscillations in cerebral vessels: applications in carotid artery disease and ischemic stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association\| PubMed ID: 20864356	2010
Combined optical and X-ray tomosynthesis breast imaging. Radiology\| PubMed ID: 21062924	2011
Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 21179069	2011
Compositional-prior-guided image reconstruction algorithm for multi-modality imaging. Biomedical optics express\| PubMed ID: 21258460	2010
Resting state functional connectivity of the whole head with near-infrared spectroscopy. Biomedical optics express\| PubMed ID: 21258470	2010
Monte Carlo simulation of the spatial resolution and depth sensitivity of two-dimensional optical imaging of the brain. Journal of biomedical optics\| PubMed ID: 21280912	2011
Optical coherence tomography for the quantitative study of cerebrovascular physiology. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 21364599	2011
Improved recovery of the hemodynamic response in diffuse optical imaging using short optode separations and state-space modeling. NeuroImage\| PubMed ID: 21385616	2011
Assessment of the frequency-domain multi-distance method to evaluate the brain optical properties: Monte Carlo simulations from neonate to adult. Biomedical optics express\| PubMed ID: 21412461	2011
Multiphysics neuron model for cellular volume dynamics. IEEE transactions on bio-medical engineering\| PubMed ID: 21659016	2011
Laser speckle imaging in the spatial frequency domain. Biomedical optics express\| PubMed ID: 21698018	2011
Due to intravascular multiple sequential scattering, Diffuse Correlation Spectroscopy of tissue primarily measures relative red blood cell motion within vessels. Biomedical optics express\| PubMed ID: 21750779	2011
"Overshoot" of Oâ‚‚ is required to maintain baseline tissue oxygenation at locations distal to blood vessels. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21940458	2011
Short separation channel location impacts the performance of short channel regression in NIRS. NeuroImage\| PubMed ID: 21945793	2012
Haemoglobin oxygen saturation as a biomarker: the problem and a solution. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences\| PubMed ID: 22006898	2011
Cortical spreading depression impairs oxygen delivery and metabolism in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 22008729	2012
Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response. Journal of biomedical optics\| PubMed ID: 22029350	2011
Quantification of the cortical contribution to the NIRS signal over the motor cortex using concurrent NIRS-fMRI measurements. NeuroImage\| PubMed ID: 22036999	2011
Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex. Optics express\| PubMed ID: 22108978	2011
The utility of near-infrared spectroscopy in the regression of low-frequency physiological noise from functional magnetic resonance imaging data. NeuroImage\| PubMed ID: 22119653	2011
Frontiers in optical imaging of cerebral blood flow and metabolism. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 22252238	2012