Anthony Kossiakoff

The Recombinant Antibody Network

Affiliated withThe Recombinant Antibody Network The University of Chicago

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 33	2015

Other Publications

Article	Year
Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between rece... Journal of molecular biology\| PubMed ID: 11851338	2002
Functional promiscuity of squirrel monkey growth hormone receptor toward both primate and nonprimate growth hormones. Molecular biology and evolution\| PubMed ID: 12082127	2002
Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12552121	2003
The first semi-synthetic serine protease made by native chemical ligation. Protein expression and purification\| PubMed ID: 12767808	2003
Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization. Protein science : a publication of the Protein Society\| PubMed ID: 12930995	2003
The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affini... Journal of molecular biology\| PubMed ID: 12946357	2003
Dissecting the binding energy epitope of a high-affinity variant of human growth hormone: cooperative and additive effects from combining mutations from independently selected phage display ... Biochemistry\| PubMed ID: 15147191	2004
The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors. Advances in protein chemistry\| PubMed ID: 15500861	2004
The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15563602	2004
The crystal structure of a quercetin 2,3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s). Biochemistry\| PubMed ID: 15628860	2005
Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis. Journal of molecular biology\| PubMed ID: 15755445	2005
Total chemical synthesis and X-ray crystal structure of a protein diastereomer: [D-Gln 35]ubiquitin. Angewandte Chemie (International ed. in English)\| PubMed ID: 15834850	2005
Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface. The Journal of biological chemistry\| PubMed ID: 15857837	2005
Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis. Protein science : a publication of the Protein Society\| PubMed ID: 16131663	2005
The crystal structure of Aq_328 from the hyperthermophilic bacteria Aquifex aeolicus shows an ancestral histone fold. Proteins\| PubMed ID: 16287087	2006
Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis. Nature chemical biology\| PubMed ID: 16446709	2006
Crystal structure and site 1 binding energetics of human placental lactogen. Journal of molecular biology\| PubMed ID: 16546209	2006
Structure of bistramide A-actin complex at a 1.35 angstroms resolution. Journal of the American Chemical Society\| PubMed ID: 16551075	2006
Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning. The Journal of biological chemistry\| PubMed ID: 16762925	2006
The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by H/D exchange mass spectrometry. Biochemistry\| PubMed ID: 16834322	2006
Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization. Angewandte Chemie (International ed. in English)\| PubMed ID: 17099920	2006
Exploring and designing protein function with restricted diversity. Current opinion in chemical biology\| PubMed ID: 17500026	2007
High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries. Journal of molecular biology\| PubMed ID: 17825836	2007
Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope. Journal of molecular biology\| PubMed ID: 17888451	2007
Synthetic antibodies for specific recognition and crystallization of structured RNA. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18162543	2008
The 1.38 A crystal structure of DmsD protein from Salmonella typhimurium, a proofreading chaperone on the Tat pathway. Proteins\| PubMed ID: 18175314	2008
Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold. Protein science : a publication of the Protein Society\| PubMed ID: 18445622	2008
X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers. Journal of the American Chemical Society\| PubMed ID: 18598029	2008
Understanding mechanisms governing protein-protein interactions from synthetic binding interfaces. Current opinion in structural biology\| PubMed ID: 18638552	2008
X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods. Journal of the American Chemical Society\| PubMed ID: 19133782	2009
Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side-chain interactions. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19196954	2009
Crystal structure of full-length KcsA in its closed conformation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19346472	2009
Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods. Protein science : a publication of the Protein Society\| PubMed ID: 19472324	2009
An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19549879	2009
Role of a salt bridge in the model protein crambin explored by chemical protein synthesis: X-ray structure of a unique protein analogue, [V15A]crambin-alpha-carboxamide. Molecular bioSystems\| PubMed ID: 19562114	2009
Keeping signaling in check. Structure (London, England : 1993)\| PubMed ID: 20223207	2010
Characterization of engineered actin binding proteins that control filament assembly and structure. PloS one\| PubMed ID: 21103060	2010
A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination. Nature structural & molecular biology\| PubMed ID: 21151117	2011
Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins. Nature structural & molecular biology\| PubMed ID: 21378967	2011
Mechanism of activation gating in the full-length KcsA K+ channel. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21730186	2011
Substance P derivatives as versatile tools for specific delivery of various types of biomolecular cargo. Bioconjugate chemistry\| PubMed ID: 22175275	2012
Generating conformation-specific synthetic antibodies to trap proteins in selected functional states. Methods (San Diego, Calif.)\| PubMed ID: 23280336	2013
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature\| PubMed ID: 23604254	2013
Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain. Nature structural & molecular biology\| PubMed ID: 24487958	2014
Cell biology. New tricks for an old dimer. Science (New York, N.Y.)\| PubMed ID: 24833381	2014
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation. Cell reports\| PubMed ID: 24981860	2014
Visualization of arrestin recruitment by a G-protein-coupled receptor. Nature\| PubMed ID: 25043026	2014
Probing the functions of the paramyxovirus glycoproteins F and HN with a panel of synthetic antibodies. Journal of virology\| PubMed ID: 25122782	2014
Applications for an engineered Protein-G variant with a pH controllable affinity to antibody fragments. Journal of immunological methods\| PubMed ID: 25450256	2014
Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling. Cell communication and signaling : CCS\| PubMed ID: 25589173	2015