Mark A. Behlke

Integrated Dna Technologies, Inc.

Affiliated withIntegrated Dna Technologies, Inc.

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2014

Other Publications

Article	Year
Structure-function relationships of shared-stem and conventional molecular beacons. Nucleic acids research\| PubMed ID: 12364599	2002
Hybridization of 2'-O-methyl and 2'-deoxy molecular beacons to RNA and DNA targets. Nucleic acids research\| PubMed ID: 12466541	2002
Hybridization kinetics and thermodynamics of molecular beacons. Nucleic acids research\| PubMed ID: 12582252	2003
Hybridization of 2'-O-methyl and 2'-deoxy molecular beacons to RNA and DNA targets. Nucleic acids research\| PubMed ID: 12669716	2003
Spectroscopic features of dual fluorescence/luminescence resonance energy-transfer molecular beacons. Analytical chemistry\| PubMed ID: 14572032	2003
Thermodynamic treatment of oligonucleotide duplex-simplex equilibria. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14657395	2003
Effects of sodium ions on DNA duplex oligomers: improved predictions of melting temperatures. Biochemistry\| PubMed ID: 15035624	2004
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nature biotechnology\| PubMed ID: 15619617	2005
Effects of fluorescent dyes, quenchers, and dangling ends on DNA duplex stability. Biochemical and biophysical research communications\| PubMed ID: 15629139	2005
A potential role for RNA interference in controlling the activity of the human LINE-1 retrotransposon. Nucleic acids research\| PubMed ID: 15701756	2005
Functional polarity is introduced by Dicer processing of short substrate RNAs. Nucleic acids research\| PubMed ID: 16049023	2005
Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction. Virology\| PubMed ID: 16216295	2006
Progress towards in vivo use of siRNAs. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16481219	2006
Characterization of modified antisense oligonucleotides in Xenopus laevis embryos. Oligonucleotides\| PubMed ID: 16584293	2006
Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro. Nature biotechnology\| PubMed ID: 16648841	2006
A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells. Nature biotechnology\| PubMed ID: 16648842	2006
Design of LNA probes that improve mismatch discrimination. Nucleic acids research\| PubMed ID: 16670427	2006
Rational design and in vitro and in vivo delivery of Dicer substrate siRNA. Nature protocols\| PubMed ID: 17406276	2006
Design of active small interfering RNAs. Current opinion in molecular therapeutics\| PubMed ID: 17458163	2007
Avoiding false-positive signals with nuclease-vulnerable molecular beacons in single living cells. Nucleic acids research\| PubMed ID: 17702767	2007
Advances in molecular and cellular therapies for hearing loss. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18223547	2008
TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18250417	2008
Predicting stability of DNA duplexes in solutions containing magnesium and monovalent cations. Biochemistry\| PubMed ID: 18422348	2008
Determinants of cytokine induction by small interfering RNA in human peripheral blood mononuclear cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research\| PubMed ID: 18439100	2008
Efficient cytosolic delivery of molecular beacon conjugates and flow cytometric analysis of target RNA. Nucleic acids research\| PubMed ID: 18503086	2008
Central delivery of Dicer-substrate siRNA: a direct application for pain research. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18523447	2008
Chemical modification patterns compatible with high potency dicer-substrate small interfering RNAs. Oligonucleotides\| PubMed ID: 18637735	2008
Assessing the sensitivity of commercially available fluorophores to the intracellular environment. Analytical chemistry\| PubMed ID: 18700780	2008
Regulation of bacteria-induced intercellular adhesion molecule-1 by CCAAT/enhancer binding proteins. American journal of respiratory cell and molecular biology\| PubMed ID: 18703796	2009
Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18827803	2009
A role for the Dicer helicase domain in the processing of thermodynamically unstable hairpin RNAs. Nucleic acids research\| PubMed ID: 18927112	2008
Chemical modification of siRNAs for in vivo use. Oligonucleotides\| PubMed ID: 19025401	2008
Gene silencing by synthetic U1 adaptors. Nature biotechnology\| PubMed ID: 19219028	2009
The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test. Pain\| PubMed ID: 19464798	2009
Sub-cellular trafficking and functionality of 2'-O-methyl and 2'-O-methyl-phosphorothioate molecular beacons. Nucleic acids research\| PubMed ID: 19820111	2009
Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs. RNA (New York, N.Y.)\| PubMed ID: 19948766	2010
Rational design of immunostimulatory siRNAs. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20125126	2010
A direct comparison of anti-microRNA oligonucleotide potency. Pharmaceutical research\| PubMed ID: 20424893	2010
Ratiometric bimolecular beacons for the sensitive detection of RNA in single living cells. Nucleic acids research\| PubMed ID: 20507905	2010
Genetic modulation of TLR8 response following bacterial phagocytosis. Human mutation\| PubMed ID: 20652908	2010
Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology\| PubMed ID: 20889220	2010
A role for human Dicer in pre-RISC loading of siRNAs. Nucleic acids research\| PubMed ID: 20972213	2011
miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors. The EMBO journal\| PubMed ID: 21285947	2011
siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo. Immunology and cell biology\| PubMed ID: 21423261	2012
Analysis of microRNA turnover in mammalian cells following Dicer1 ablation. Nucleic acids research\| PubMed ID: 21447562	2011
Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress. Cell metabolism\| PubMed ID: 21723502	2011
Nucleotide bias observed with a short SELEX RNA aptamer library. Nucleic acid therapeutics\| PubMed ID: 21793789	2011
RNase H-dependent PCR (rhPCR): improved specificity and single nucleotide polymorphism detection using blocked cleavable primers. BMC biotechnology\| PubMed ID: 21831278	2011
Synthesis and characterization of mannosylated pegylated polyethylenimine as a carrier for siRNA. International journal of pharmaceutics\| PubMed ID: 21864664	2012
Protection against TNFα-dependent liver toxicity by intraperitoneal liposome delivered DsiRNA targeting TNFα in vivo. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 22094102	2012
Progress toward in vivo use of siRNAs-II. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22186795	2012
Degradation of nuclease-stabilized RNA oligonucleotides in Mycoplasma-contaminated cell culture media. Nucleic acid therapeutics\| PubMed ID: 22229275	2012
Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization. ISRN pharmaceutics\| PubMed ID: 22474606	2012
A miR-19 regulon that controls NF-κB signaling. Nucleic acids research\| PubMed ID: 22684508	2012
RNA aptamer-based functional ligands of the neurotrophin receptor, TrkB. Molecular pharmacology\| PubMed ID: 22752556	2012
Pancreas-enriched miRNA refines endocrine cell differentiation. Development (Cambridge, England)\| PubMed ID: 22764048	2012
Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing. Nucleic acids research\| PubMed ID: 22810205	2012
A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22853952	2012
RNA inhibition highlights cyclin D1 as a potential therapeutic target for mantle cell lymphoma. PloS one\| PubMed ID: 22905260	2012
Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection. PloS one\| PubMed ID: 22962591	2012
Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins. RNA (New York, N.Y.)\| PubMed ID: 23019594	2012
In vivo SELEX for Identification of Brain-penetrating Aptamers. Molecular therapy. Nucleic acids\| PubMed ID: 23299833	2013
Deep Sequencing Analyses of DsiRNAs Reveal the Influence of 3' Terminal Overhangs on Dicing Polarity, Strand Selectivity, and RNA Editing of siRNAs. Molecular therapy. Nucleic acids\| PubMed ID: 23343928	2012
Manipulation of Cell Physiology Enables Gene Silencing in Well-differentiated Airway Epithelia. Molecular therapy. Nucleic acids\| PubMed ID: 23344182	2012
Targeting IκB proteins for HIV latency activation: the role of individual IκB and NF-κB proteins. Journal of virology\| PubMed ID: 23365428	2013
Altered Purkinje cell miRNA expression and SCA1 pathogenesis. Neurobiology of disease\| PubMed ID: 23376683	2013
Efficient delivery of RNA interference oligonucleotides to polarized airway epithelia in vitro. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 23624792	2013
Post-transcriptional regulation of cystic fibrosis transmembrane conductance regulator expression and function by microRNAs. American journal of respiratory cell and molecular biology\| PubMed ID: 23646886	2013
U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo. Molecular therapy. Nucleic acids\| PubMed ID: 23673539	2013
Spinal NTS2 receptor activation reverses signs of neuropathic pain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 23756650	2013
Quantitative assessment of ratiometric bimolecular beacons as a tool for imaging single engineered RNA transcripts and measuring gene expression in living cells. Nucleic acids research\| PubMed ID: 23814183	2013
Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier. Molecular therapy. Nucleic acids\| PubMed ID: 23982190	2013
SNP detection in mRNA in living cells using allele specific FRET probes. PloS one\| PubMed ID: 24039756	2013
Knockdown of β-catenin with dicer-substrate siRNAs reduces liver tumor burden in vivo. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 24089139	2014
In vivo comparison of local versus systemic delivery of immunostimulating siRNA in HPV-driven tumours. Immunology and cell biology\| PubMed ID: 24217808	2014
Inosine-mediated modulation of RNA sensing by Toll-like receptor 7 (TLR7) and TLR8. Journal of virology\| PubMed ID: 24227841	2014
Correction: SNP Detection in mRNA in Living Cells Using Allele Specific FRET Probes. PloS one\| PubMed ID: 24244230	2013
Imaging the directed transport of single engineered RNA transcripts in real-time using ratiometric bimolecular beacons. PloS one\| PubMed ID: 24454933	2014
Noninvasive imaging of Staphylococcus aureus infections with a nuclease-activated probe. Nature medicine\| PubMed ID: 24487433	2014
Platelet Activating Factor Receptor Activation Improves siRNA Uptake and RNAi Responses in Well-differentiated Airway Epithelia. Molecular therapy. Nucleic acids\| PubMed ID: 25025465	2014