Tony Velkov

Drug Delivery, Monash University

Affiliated withMonash University The University of Melbourne

Research Area

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 26	2014
Publication title Cited by 18	2017
Publication title Cited by 3	2022
Publication title Cited by 5	2022

Other Publications

Article	Year
Pulsed-voltage atom probe tomography of low conductivity and insulator materials by application of ultrathin metallic coating on nanoscale specimen geometry. Ultramicroscopy\| PubMed ID: 28558288	2017
Mapping and molecular modeling of S-adenosyl-L-methionine binding sites in N-methyltransferase domains of the multifunctional polypeptide cyclosporin synthetase. The Journal of biological chemistry\| PubMed ID: 12399454	2003
Photoaffinity labeling of the N-methyltransferase domains of cyclosporin synthetase. Photochemistry and photobiology\| PubMed ID: 12785050	2003
Non-ribosomal peptide synthetases as technological platforms for the synthesis of highly modified peptide bioeffectors--Cyclosporin synthetase as a complex example. Biotechnology annual review\| PubMed ID: 14650927	2003
The interaction of lipophilic drugs with intestinal fatty acid-binding protein. The Journal of biological chemistry\| PubMed ID: 15722357	2005
An improved method for the purification of rat liver-type fatty acid binding protein from Escherichia coli. Protein expression and purification\| PubMed ID: 15914028	2005
An improved purification procedure for cyclosporin synthetase. Protein expression and purification\| PubMed ID: 16139518	2006
Generation of mutant leukaemia inhibitory factor (LIF)-IgG heavy chain fusion proteins as bivalent antagonists of LIF. Journal of immunological methods\| PubMed ID: 17408687	2007
Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay. Chemistry & biology\| PubMed ID: 17462580	2007
Probing the flexibility of the DsbA oxidoreductase from Vibrio cholerae--a 15N - 1H heteronuclear NMR relaxation analysis of oxidized and reduced forms of DsbA. Journal of molecular biology\| PubMed ID: 17585933	2007
A protocol for the combined sub-fractionation and delipidation of lipid binding proteins using hydrophobic interaction chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 18456580	2008
Characterization of the drug binding specificity of rat liver fatty acid binding protein. Journal of medicinal chemistry\| PubMed ID: 18533710	2008
Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis. The Journal of biological chemistry\| PubMed ID: 18715864	2008
Ni2+-based immobilized metal ion affinity chromatography of lactose operon repressor protein from Escherichia coli. Preparative biochemistry & biotechnology\| PubMed ID: 18800304	2008
Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein. Molecular and cellular biochemistry\| PubMed ID: 19160019	2009
Thermodynamics of lipophilic drug binding to intestinal fatty acid binding protein and permeation across membranes. Molecular pharmaceutics\| PubMed ID: 19265444	2009
Probing the fibrate binding specificity of rat liver fatty acid binding protein. Journal of medicinal chemistry\| PubMed ID: 19663428	2009
Ligand-enhanced expression and in-cell assay of human peroxisome proliferator-activated receptor alpha ligand binding domain. Protein expression and purification\| PubMed ID: 19782138	2010
Structure--activity relationships of polymyxin antibiotics. Journal of medicinal chemistry\| PubMed ID: 19874036	2010
Self-assembly behavior of colistin and its prodrug colistin methanesulfonate: implications for solution stability and solubilization. The journal of physical chemistry. B\| PubMed ID: 20302384	2010
Developing an anion host for lipid A binding and antibacterial activity. Chemical communications (Cambridge, England)\| PubMed ID: 20424772	2010
Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions. Analytical biochemistry\| PubMed ID: 21050838	2011
Characterization of the N-methyltransferase activities of the multifunctional polypeptide cyclosporin synthetase. Chemistry & biology\| PubMed ID: 21513883	2011
Structure-activity relationships for the binding of polymyxins with human α-1-acid glycoprotein. Biochemical pharmacology\| PubMed ID: 22587817	2012
The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic m... Antimicrobial agents and chemotherapy\| PubMed ID: 22802247	2012
Analysis of phosphopeptide changes as spermatozoa acquire functional competence in the epididymis demonstrates changes in the post-translational modification of Izumo1. Journal of proteome research\| PubMed ID: 22954305	2012
Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A. Innate immunity\| PubMed ID: 23008349	2013
Reverse engineering the antigenic architecture of the haemagglutinin from influenza H5N1 clade 1 and 2.2 viruses with fine epitope mapping using monoclonal antibodies. Molecular immunology\| PubMed ID: 23127859	2013
Head and flagella subcompartmental proteomic analysis of human spermatozoa. Proteomics\| PubMed ID: 23161668	2013
Drug-binding energetics of human α-1-acid glycoprotein assessed by isothermal titration calorimetry and molecular docking simulations. Journal of molecular recognition : JMR\| PubMed ID: 23192962	2012
Molecular Characterization of Lipopolysaccharide Binding to Human α-1-Acid Glycoprotein. Journal of lipids\| PubMed ID: 23316371	2012
Interactions between Human Liver Fatty Acid Binding Protein and Peroxisome Proliferator Activated Receptor Selective Drugs. PPAR research\| PubMed ID: 23476633	2013
Pharmacology of polymyxins: new insights into an 'old' class of antibiotics. Future microbiology\| PubMed ID: 23701329	2013
Pharmacokinetics of four different brands of colistimethate and formed colistin in rats. The Journal of antimicrobial chemotherapy\| PubMed ID: 23749953	2013
Polymyxin B induces apoptosis in kidney proximal tubular cells. Antimicrobial agents and chemotherapy\| PubMed ID: 23796937	2013
Interaction of phthalates and phenoxy acid herbicide environmental pollutants with intestinal intracellular lipid binding proteins. Chemical research in toxicology\| PubMed ID: 23841907	2013
PK/PD models in antibacterial development. Current opinion in microbiology\| PubMed ID: 23871724	2013
Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae. Innate immunity\| PubMed ID: 23887184	2014
The antigenic architecture of the hemagglutinin of influenza H5N1 viruses. Molecular immunology\| PubMed ID: 23933511	2013
The specificity of the influenza B virus hemagglutinin receptor binding pocket: what does it bind to? Journal of molecular recognition : JMR\| PubMed ID: 23996486	2013
The RNA-dependent-RNA polymerase, an emerging antiviral drug target for the Hendra virus. Current drug targets\| PubMed ID: 24102407	2014
Polymyxins and analogues bind to ribosomal RNA and interfere with eukaryotic translation in vitro. Chembiochem : a European journal of chemical biology\| PubMed ID: 24105917	2013
A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity. The Journal of antibiotics\| PubMed ID: 24169795	2014
Nanoscale focused ion beam tomography of single bacterial cells for assessment of antibiotic effects. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada\| PubMed ID: 24589280	2014
Teaching 'old' polymyxins new tricks: new-generation lipopeptides targeting gram-negative 'superbugs'. ACS chemical biology\| PubMed ID: 24601489	2014
Probing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteria. Bioconjugate chemistry\| PubMed ID: 24635310	2014
Colistin and Polymyxin B: Peas in a Pod, or Chalk and Cheese? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 24700659	2014
The carbohydrate-binding promiscuity of Euonymus europaeus lectin is predicted to involve a single binding site. Glycobiology\| PubMed ID: 25209582	2015
Measuring polymyxin uptake by renal tubular cells: is BODIPY-polymyxin B an appropriate probe? Antimicrobial agents and chemotherapy\| PubMed ID: 25225340	2014
In situ probing the interior of single bacterial cells at nanometer scale. Nanotechnology\| PubMed ID: 25257833	2014
Imaging the distribution of polymyxins in the kidney. The Journal of antimicrobial chemotherapy\| PubMed ID: 25377569	2014
Lycopene Attenuates Colistin-Induced Nephrotoxicity in Mice via Activation of the Nrf2/HO-1 Pathway. Antimicrobial agents and chemotherapy\| PubMed ID: 25385104	2015
Analysis of Protein Thiol Changes Occurring During Rat Sperm Epididymal Maturation. Biology of reproduction\| PubMed ID: 25411390	2014
Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead. Advanced drug delivery reviews\| PubMed ID: 25446140	2014
Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumour-burdened lymph nodes after intravenous and subcutaneous administration in rats. Molecular pharmaceutics\| PubMed ID: 25485615	2014
Significant accumulation of polymyxin in single renal tubular cells: a medicinal chemistry and triple correlative microscopy approach. Analytical chemistry\| PubMed ID: 25553489	2015
Major pathways of polymyxin-induced apoptosis in rat kidney proximal tubular cells. Antimicrobial agents and chemotherapy\| PubMed ID: 25624331	2015
Two mechanisms of killing of Pseudomonas aeruginosa by tobramycin assessed at multiple inocula via mechanism-based modeling. Antimicrobial agents and chemotherapy\| PubMed ID: 25645838	2015
Defining the mechanisms by which the reactive oxygen species by-product, 4-hydroxynonenal, affects human sperm cell function. Biology of reproduction\| PubMed ID: 25673561	2015
Drug-drug plasma protein binding interactions of ivacaftor. Journal of molecular recognition : JMR\| PubMed ID: 25707701	2015
Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner. The Journal of biological chemistry\| PubMed ID: 25847235	2015
Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two 'old' antibiotics-polymyxin B and chloramphenicol. The Journal of antimicrobial chemotherapy\| PubMed ID: 26023209	2015
Molecular Characterisation of the Haemagglutinin Glycan-Binding Specificity of Egg-Adapted Vaccine Strains of the Pandemic 2009 H1N1 Swine Influenza A Virus. Molecules (Basel, Switzerland)\| PubMed ID: 26056814	2015
Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy. Molecular neurobiology\| PubMed ID: 26316077	2016
Cellular Uptake and Localization of Polymyxins in Renal Tubular Cells Using Rationally Designed Fluorescent Probes. Antimicrobial agents and chemotherapy\| PubMed ID: 26392495	2015
Cold adaptation generates mutations associated with the growth of influenza B vaccine viruses. Vaccine\| PubMed ID: 26407922	2015
Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii. The Journal of antibiotics\| PubMed ID: 26669752	2016
Quantitation of Polymyxin-Lipopolysaccharide Interactions Using an Image-Based Fluorescent Probe. Journal of pharmaceutical sciences\| PubMed ID: 26869441	2016
Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii. Scientific reports\| PubMed ID: 26924392	2016
Antibacterial Low Molecular Weight Cationic Polymers: Dissecting the Contribution of Hydrophobicity, Chain Length and Charge to Activity. RSC advances\| PubMed ID: 26998253	2016
Pharmacokinetics of levobupivacaine following infant spinal anesthesia. Paediatric anaesthesia\| PubMed ID: 27061607	2016
Polymyxins: a new hope in combating Gram-negative superbugs? Future medicinal chemistry\| PubMed ID: 27328129	2016
Transcriptomic Analysis of the Activity of a Novel Polymyxin against Staphylococcus aureus. mSphere\| PubMed ID: 27471750	2016
Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-line Antibiotics against Multidrug-Resistant Gram-negative Bacteria. ACS infectious diseases\| PubMed ID: 27525307	2015
A Hydrogel-Based Localized Release of Colistin for Antimicrobial Treatment of Burn Wound Infection. Macromolecular bioscience\| PubMed ID: 27619320	2017
An "Unlikely" Pair: The Antimicrobial Synergy of Polymyxin B in Combination with the Cystic Fibrosis Transmembrane Conductance Regulator Drugs KALYDECO and ORKAMBI. ACS infectious diseases\| PubMed ID: 27626100	2016
A Novel Chemical Biology Approach for Mapping of Polymyxin Lipopeptide Antibody Binding Epitopes. ACS infectious diseases\| PubMed ID: 27627202	2016
Near-Atomic Three-Dimensional Mapping for Site-Specific Chemistry of 'Superbugs'. Nano letters\| PubMed ID: 27650306	2016
The Plasma Protein Binding Proteome of Ertapenem: A Novel Compound-Centric Proteomic Approach for Elucidating Drug-Plasma Protein Binding Interactions. ACS chemical biology\| PubMed ID: 27682196	2016
Deficiency in Outer Dense Fiber 1 Is a Marker and Potential Driver of Idiopathic Male Infertility. Molecular & cellular proteomics : MCP\| PubMed ID: 27770032	2016
Development of HPLC and LC-MS/MS methods for the analysis of ivacaftor, its major metabolites and lumacaftor in plasma and sputum of cystic fibrosis patients treated with ORKAMBI or KALYDECO... Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 27792891	2016
Pharmacokinetics/pharmacodynamics of colistin and polymyxin B: are we there yet? International journal of antimicrobial agents\| PubMed ID: 27793510	2016
From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "Superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators. Microbial drug resistance (Larchmont, N.Y.)\| PubMed ID: 27935770	2017
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis. Molecular neurobiology\| PubMed ID: 27957686	2016
Functional Characterization of the Unique Terminal Thioesterase Domain from Polymyxin Synthetase. Biochemistry\| PubMed ID: 28071053	2017
Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats. Journal of natural products\| PubMed ID: 28080060	2017
Plasma Protein Binding Structure-Activity Relationships Related to the N-Terminus of Daptomycin. ACS infectious diseases\| PubMed ID: 28142234	2017
A traceless reversible polymeric colistin prodrug to combat multidrug-resistant (MDR) gram-negative bacteria. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 28174100	2017
Rediscovering the octapeptins. Natural product reports\| PubMed ID: 28180225	2017
Minocycline attenuates colistin-induced neurotoxicity via suppression of apoptosis, mitochondrial dysfunction and oxidative stress. The Journal of antimicrobial chemotherapy\| PubMed ID: 28204513	2017
The thermodynamics of Pr55Gag-RNA interaction regulate the assembly of HIV. PLoS pathogens\| PubMed ID: 28222188	2017
Antibiotic-non-antibiotic combinations for combating extremely drug-resistant Gram-negative 'superbugs'. Essays in biochemistry\| PubMed ID: 28258235	2017
Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii. Scientific reports\| PubMed ID: 28358014	2017
Potential Toxicity of Polymyxins in Human Lung Epithelial Cells. Antimicrobial agents and chemotherapy\| PubMed ID: 28416543	2017
Pharmacokinetics and relative bioavailability of an oral amoxicillin-apramycin combination in pigs. PloS one\| PubMed ID: 28426744	2017
Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401. Journal of natural products\| PubMed ID: 28463513	2017
Deficiency in outer dense fiber 1 is a marker and potential driver of idiopathic male infertility. Molecular & cellular proteomics : MCP\| PubMed ID: 28572402	2017
Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]-Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization. Bioconjugate chemistry\| PubMed ID: 28657722	2017
Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes. ACS infectious diseases\| PubMed ID: 28695731	2017
Polymyxins for CNS infections: Pharmacology and neurotoxicity. Pharmacology & therapeutics\| PubMed ID: 28750947	2017
The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity. Organic & biomolecular chemistry\| PubMed ID: 28812779	2017
Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory resp... The Journal of antimicrobial chemotherapy\| PubMed ID: 28859441	2017
Aminoglycoside concentrations required for synergy with carbapenems against Pseudomonas aeruginosa determined via mechanistic studies and modeling. Antimicrobial agents and chemotherapy\| PubMed ID: 28893782	2017
Gelofusine ameliorates colistin-induced nephrotoxicity. Antimicrobial agents and chemotherapy\| PubMed ID: 28923868	2017
Cationic Acrylate Oligomers Comprising Amino Acid Mimic Moieties Demonstrate Improved Antibacterial Killing Efficiency. Journal of materials chemistry. B, Materials for biology and medicine\| PubMed ID: 28966792	2017
Design and Evaluation of Novel Polymyxin Fluorescent Probes. Sensors (Basel, Switzerland)\| PubMed ID: 29137129	2017
Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance. ACS chemical biology\| PubMed ID: 29182311	2018
A Portrait of the Sialyl Glycan Receptor Specificity of the H10 Influenza Virus Hemagglutinin-A Picture of an Avian Virus on the Verge of Becoming a Pandemic? Vaccines\| PubMed ID: 29236069	2017
Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways. ACS chemical neuroscience\| PubMed ID: 29257864	2018
Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria. Cell chemical biology\| PubMed ID: 29396290	2018
T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 29432840	2018
A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens. Antimicrobial agents and chemotherapy\| PubMed ID: 29439974	2018
The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites. ERJ open research\| PubMed ID: 29560360	2018
Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules. ACS infectious diseases\| PubMed ID: 29566483	2018
Polymyxin B in Combination with Enrofloxacin Exerts Synergistic Killing against Extensively Drug-Resistant Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy\| PubMed ID: 29632010	2018
Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy\| PubMed ID: 29632014	2018
Novel Polymyxin Combination With Antineoplastic Mitotane Improved the Bacterial Killing Against Polymyxin-Resistant Multidrug-Resistant Gram-Negative Pathogens. Frontiers in microbiology\| PubMed ID: 29706941	2018
Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant : A Metabolomic Study. Frontiers in pharmacology\| PubMed ID: 29713282	2018
Composite particle formulations of colistin and meropenem with improved in-vitro bacterial killing and aerosolization for inhalation. International journal of pharmaceutics\| PubMed ID: 30008433	2018
Lipidomic Analysis of the Outer Membrane Vesicles from Paired Polymyxin-Susceptible and -Resistant Clinical Isolates. International journal of molecular sciences\| PubMed ID: 30103446	2018
A Comparative Study of Outer Membrane Proteome between Paired Colistin-Susceptible and Extremely Colistin-Resistant Klebsiella pneumoniae Strains. ACS infectious diseases\| PubMed ID: 30232886	2018
Exploiting Macromolecular Design To Optimize the Antibacterial Activity of Alkylated Cationic Oligomers. Biomacromolecules\| PubMed ID: 30359516	2018
Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention. ACS chemical neuroscience\| PubMed ID: 30362702	2019
Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis. Cell death & disease\| PubMed ID: 30478280	2018
Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant . Frontiers in microbiology\| PubMed ID: 30505298	2018
Contemporary Anti-Ebola Drug Discovery Approaches and Platforms. ACS infectious diseases\| PubMed ID: 30516045	2019
Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR . Computational and structural biotechnology journal\| PubMed ID: 30546859	2018
Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa. mSystems\| PubMed ID: 30637340	2019
Novel Polymyxin Combination with the Antiretroviral Zidovudine Exerts Synergistic Killing against NDM-Producing Multidrug-Resistant Klebsiella pneumoniae. Antimicrobial agents and chemotherapy\| PubMed ID: 30670431	2019
Effects of the antibiotic component on in-vitro bacterial killing, physico-chemical properties, aerosolization and dissolution of a ternary-combinational inhalation powder formulation of ant... International journal of pharmaceutics\| PubMed ID: 30797863	2019
Global Metabolic Analyses of Acinetobacter baumannii. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30798566	2019
The rise and spread of plasmid-mediated polymyxin resistance. Critical reviews in microbiology\| PubMed ID: 31122100	2019
Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant . Frontiers in pharmacology\| PubMed ID: 31333468	2019
Polymyxins: Mode of Action. Advances in experimental medicine and biology\| PubMed ID: 31364070	2019
Mechanisms of Polymyxin-Induced Nephrotoxicity. Advances in experimental medicine and biology\| PubMed ID: 31364084	2019
Discovery of Novel Polymyxin-Like Antibiotics. Advances in experimental medicine and biology\| PubMed ID: 31364086	2019
Multifaceted mechanisms of colistin resistance revealed by genomic analysis of multidrug-resistant Klebsiella pneumoniae isolates from individual patients before and after colistin treatment... The Journal of infection\| PubMed ID: 31374222	2019
The impact of backbone N-methylation on the structure-activity relationship of Leu -teixobactin. Journal of peptide science : an official publication of the European Peptide Society\| PubMed ID: 31389086	2019
T-2 toxin neurotoxicity: role of oxidative stress and mitochondrial dysfunction. Archives of toxicology\| PubMed ID: 31570981	2019
An optimised Cu(0)-RDRP approach for the synthesis of lipidated oligomeric vinyl azlactone: toward a versatile antimicrobial materials screening platform. Journal of materials chemistry. B\| PubMed ID: 31603181	2019
Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy\| PubMed ID: 31611351	2019
Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-Resistant . Frontiers in pharmacology\| PubMed ID: 31632279	2019
DNA variants are an unlikely explanation for the changing quality of spermatozoa within the same individual. Human fertility (Cambridge, England)\| PubMed ID: 31642381	2021
Synthesis and structure-activity relationships of teixobactin. Annals of the New York Academy of Sciences\| PubMed ID: 31792983	2020
Inhalable liposomal powder formulations for co-delivery of synergistic ciprofloxacin and colistin against multi-drug resistant gram-negative lung infections. International journal of pharmaceutics\| PubMed ID: 31816354	2020
Structure of micelle bound cationic peptides by NMR spectroscopy using a lanthanide shift reagent. Chemical communications (Cambridge, England)\| PubMed ID: 32037418	2020
Curcumin Attenuates Colistin-Induced Peripheral Neurotoxicity in Mice. ACS infectious diseases\| PubMed ID: 32037797	2020
Complete genome sequence and genome-scale metabolic modelling of Acinetobacter baumannii type strain ATCC 19606. International journal of medical microbiology : IJMM\| PubMed ID: 32081464	2020
Regulating polymyxin resistance in Gram-negative bacteria: roles of two-component systems PhoPQ and PmrAB. Future microbiology\| PubMed ID: 32250173	2020
Polymyxin Triple Combinations against Polymyxin-Resistant, Multidrug-Resistant, KPC-Producing Klebsiella pneumoniae. Antimicrobial agents and chemotherapy\| PubMed ID: 32393492	2020
Nerve Growth Factor Confers Neuroprotection against Colistin-Induced Peripheral Neurotoxicity. ACS infectious diseases\| PubMed ID: 32422040	2020
Effective Strategy Targeting Polymyxin-Resistant Gram-Negative Pathogens: Polymyxin B in Combination with the Selective Serotonin Reuptake Inhibitor Sertraline. ACS infectious diseases\| PubMed ID: 32427476	2020
The Killing Mechanism of Teixobactin against Methicillin-Resistant Staphylococcus aureus: an Untargeted Metabolomics Study. mSystems\| PubMed ID: 32457238	2020
Polymyxins-Curcumin Combination Antimicrobial Therapy: Safety Implications and Efficacy for Infection Treatment. Antioxidants (Basel, Switzerland)\| PubMed ID: 32526966	2020
Transcriptomic responses of a New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae isolate to the combination of polymyxin B and chloramphenicol. International journal of antimicrobial agents\| PubMed ID: 32574791	2020
Polymyxin-Induced Cell Death of Human Macrophage-Like THP-1 and Neutrophil-Like HL-60 Cells Associated with the Activation of Apoptotic Pathways. Antimicrobial agents and chemotherapy\| PubMed ID: 32660985	2020
The Antimicrobial Activity of Cannabinoids. Antibiotics (Basel, Switzerland)\| PubMed ID: 32668669	2020
Structure-Activity Relationships of Daptomycin Lipopeptides. Journal of medicinal chemistry\| PubMed ID: 32687352	2020
Lipid A profiling and metabolomics analysis of paired polymyxin-susceptible and -resistant MDR Klebsiella pneumoniae clinical isolates from the same patients before and after colistin treatm... The Journal of antimicrobial chemotherapy\| PubMed ID: 32696049	2020
Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination. JCI insight\| PubMed ID: 32853178	2020
Simulations of octapeptin-outer membrane interactions reveal conformational flexibility is linked to antimicrobial potency. The Journal of biological chemistry\| PubMed ID: 32913118	2020
Polymyxin B combinations with FDA-approved non-antibiotic phenothiazine drugs targeting multi-drug resistance of Gram-negative pathogens. Computational and structural biotechnology journal\| PubMed ID: 32952938	2020
In vitro evaluation of drug delivery behavior for inhalable amorphous nanoparticle formulations in a human lung epithelial cell model. International journal of pharmaceutics\| PubMed ID: 33486036	2021
Evaluation Strategies for Triple-Drug Combinations against Carbapenemase-Producing Klebsiella Pneumoniae in an In Vitro Hollow-Fiber Infection Model. Clinical pharmacology and therapeutics\| PubMed ID: 33548079	2021
Synchrotron-based X-ray fluorescence microscopy reveals accumulation of polymyxins in single human alveolar epithelial cells. Antimicrobial agents and chemotherapy\| PubMed ID: 33649114	2021
Polymyxins for the treatment of lower respiratory tract infections: lessons learned from the integration of clinical pharmacokinetic studies and clinical outcomes. International journal of antimicrobial agents\| PubMed ID: 33785362	2021
Synergy of the Polymyxin-Chloramphenicol Combination against New Delhi Metallo-β-Lactamase-Producing Is Predominately Driven by Chloramphenicol. ACS infectious diseases\| PubMed ID: 33834753	2021
Clinically Relevant Concentrations of Polymyxin B and Meropenem Synergistically Kill Multidrug-Resistant and Minimize Biofilm Formation. Antibiotics (Basel, Switzerland)\| PubMed ID: 33918040	2021
Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury. Antioxidants (Basel, Switzerland)\| PubMed ID: 34207230	2021
A Precision Medicine Approach to Optimize Modulator Therapy for Rare CFTR Folding Mutants. Journal of personalized medicine\| PubMed ID: 34357110	2021
Insights Into Patient Variability During Ivacaftor-Lumacaftor Therapy in Cystic Fibrosis. Frontiers in pharmacology\| PubMed ID: 34408649	2021
Coarse-grained simulations uncover Gram-negative bacterial defense against polymyxins by the outer membrane. Computational and structural biotechnology journal\| PubMed ID: 34584634	2021
Comparative metabolomics revealed key pathways associated with the synergistic killing of multidrug-resistant by a bacteriophage-polymyxin combination. Computational and structural biotechnology journal\| PubMed ID: 35070170	2022
p21 restricts influenza A virus by perturbing the viral polymerase complex and upregulating type I interferon signaling. PLoS pathogens\| PubMed ID: 35180274	2022
Unique mechanistic insights into pathways associated with the synergistic activity of polymyxin B and caspofungin against multidrug-resistant . Computational and structural biotechnology journal\| PubMed ID: 35284046	2022
The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems. Antioxidants (Basel, Switzerland)\| PubMed ID: 35326110	2022
A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens. Nature communications\| PubMed ID: 35338128	2022
An Efficient Approach for the Design and Synthesis of Antimicrobial Peptide-Peptide Nucleic Acid Conjugates. Frontiers in chemistry\| PubMed ID: 35372270	2022
Colistin-induced pulmonary toxicity involves the activation of NOX4/TGF-β/mtROS pathway and the inhibition of Akt/mTOR pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 35378205	2022
Mechanisms Underlying Synergistic Killing of Polymyxin B in Combination with Cannabidiol against : A Metabolomic Study. Pharmaceutics\| PubMed ID: 35456620	2022
Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity. Cellular and molecular life sciences : CMLS\| PubMed ID: 35570209	2022
T-2 toxin and its cardiotoxicity: New insights on the molecular mechanisms and therapeutic implications. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 35792220	2022