Omar Abdel-Wahab

Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center

Affiliated withMemorial Sloan-Kettering Cancer Center

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 18	2014

Other Publications

Article	Year
Induction of anti-melanoma CTL response using DC transfected with mutated mRNA encoding full-length Melan-A/MART-1 antigen with an A27L amino acid substitution. Cellular immunology\| PubMed ID: 14609574	2003
Immunotherapy of surgical malignancies. Current problems in surgery\| PubMed ID: 14749625	2004
Modulation of resistance to regional chemotherapy in the extremity melanoma model. Surgery\| PubMed ID: 15300182	2004
In-transit melanoma: the role of alkylating-agent resistance in regional therapy. Journal of the American College of Surgeons\| PubMed ID: 15325612	2004
The role of hyperthermia in regional alkylating agent chemotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15355925	2004
Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses. The Journal of surgical research\| PubMed ID: 15820257	2005
Optimizing a novel regional chemotherapeutic agent against melanoma: hyperthermia-induced enhancement of temozolomide cytotoxicity. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16397054	2006
Modulation of chemotherapy resistance in regional therapy: a novel therapeutic approach to advanced extremity melanoma using intra-arterial temozolomide in combination with systemic O6-benzy... Molecular cancer therapeutics\| PubMed ID: 16546988	2006
Current usage of intravenous immune globulin and the rationale behind it: the Massachusetts General Hospital data and a review of the literature. Transfusion\| PubMed ID: 16686841	2006
Effect of fresh-frozen plasma transfusion on prothrombin time and bleeding in patients with mild coagulation abnormalities. Transfusion\| PubMed ID: 16934060	2006
An 87-year-old woman with respiratory distress and alveolar hemorrhage after transfusion. Chest\| PubMed ID: 17099045	2006
Functional evaluation of the grafted wall with porcine-derived small intestinal submucosa (SIS) to a stomach defect in rats. Surgery\| PubMed ID: 17723890	2007
Primary myelofibrosis: update on definition, pathogenesis, and treatment. Annual review of medicine\| PubMed ID: 18947294	2009
Warfarin-induced skin necrosis in a patient with heparin-induced thrombocytopenia: two diseases or one? Acta haematologica\| PubMed ID: 19018128	2008
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood\| PubMed ID: 19420352	2009
Cytogenetic correlates of TET2 mutations in 199 patients with myeloproliferative neoplasms. American journal of hematology\| PubMed ID: 19957346	2010
Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias. Cancer research\| PubMed ID: 20068184	2010
Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis. Blood\| PubMed ID: 20154217	2010
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer cell\| PubMed ID: 20171147	2010
Metabolism and the leukemic stem cell. The Journal of experimental medicine\| PubMed ID: 20368582	2010
Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera. Blood\| PubMed ID: 20585043	2010
Recent advances in the treatment of acute myeloid leukemia. F1000 medicine reports\| PubMed ID: 20798782	2010
The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia. Cancer cell\| PubMed ID: 20832754	2010
HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans. The Journal of clinical investigation\| PubMed ID: 20852385	2010
A mathematical framework to determine the temporal sequence of somatic genetic events in cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20864632	2010
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer cell\| PubMed ID: 21130701	2010
ETV6-ABL1-positive "chronic myeloid leukemia": clinical and molecular response to tyrosine kinase inhibition. Haematologica\| PubMed ID: 21193423	2011
Genetics of the myeloproliferative neoplasms. Current opinion in hematology\| PubMed ID: 21307773	2011
JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation. Cancer cell\| PubMed ID: 21316606	2011
Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q. The Journal of biological chemistry\| PubMed ID: 21532034	2011
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature\| PubMed ID: 21562564	2011
Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML. Blood\| PubMed ID: 21653321	2011
Clinical effect of point mutations in myelodysplastic syndromes. The New England journal of medicine\| PubMed ID: 21714648	2011
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer cell\| PubMed ID: 21723200	2011
Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy. Advances in hematology\| PubMed ID: 21811504	2012
TET family proteins and their role in stem cell differentiation and transformation. Cell stem cell\| PubMed ID: 21885017	2011
FISHing for TET2: Utility of FISH for TET2 deletions detection in clinical samples. Leukemia research\| PubMed ID: 21917313	2012
Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells yet preserves immunity to recall antigen. Blood\| PubMed ID: 21917753	2011
The spliceosome as an indicted conspirator in myeloid malignancies. Cancer cell\| PubMed ID: 22014568	2011
Clinical implications of novel mutations in epigenetic modifiers in AML. Hematology/oncology clinics of North America\| PubMed ID: 22093580	2011
Disordered epigenetic regulation in the pathophysiology of myeloproliferative neoplasms. Current hematologic malignancy reports\| PubMed ID: 22170482	2012
Nuclear JAK2. Blood\| PubMed ID: 22194397	2011
Molecular alterations underlying eosinophilic and mast cell malignancies. Discovery medicine\| PubMed ID: 22204765	2011
IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature\| PubMed ID: 22343901	2012
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. The New England journal of medicine\| PubMed ID: 22417203	2012
Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome. Blood\| PubMed ID: 22431577	2012
Unraveling the genetic underpinnings of myeloproliferative neoplasms and understanding their effect on disease course and response to therapy: proceedings from the 6th International Post-ASH... American journal of hematology\| PubMed ID: 22460584	2012
Molecular genetics of acute myeloid leukemia: clinical implications and opportunities for integrating genomics into clinical practice. Hematology (Amsterdam, Netherlands)\| PubMed ID: 22507776	2012
2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine levels. Leukemia & lymphoma\| PubMed ID: 22680765	2013
Refining the prognostic importance of the diversity of FLT3 internal tandem duplications. Leukemia & lymphoma\| PubMed ID: 22775313	2013
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy. Nature\| PubMed ID: 22820254	2012
CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900. Blood\| PubMed ID: 22855599	2012
Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 22869879	2012
Loss of the tumor suppressor BAP1 causes myeloid transformation. Science (New York, N.Y.)\| PubMed ID: 22878500	2012
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer cell\| PubMed ID: 22897849	2012
The role of mutations in epigenetic regulators in myeloid malignancies. Nature reviews. Cancer\| PubMed ID: 22898539	2012
Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): formal recommendations from the post-myeloprolifera... Leukemia research\| PubMed ID: 22938832	2012
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nature genetics\| PubMed ID: 23001125	2012
Role of TET2 and ASXL1 mutations in the pathogenesis of myeloproliferative neoplasms. Hematology/oncology clinics of North America\| PubMed ID: 23009937	2012
Epigenetic alterations in hematopoietic malignancies. International journal of hematology\| PubMed ID: 23015417	2012
Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma. European urology\| PubMed ID: 23036577	2013
Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis. Leukemia research\| PubMed ID: 23102703	2013
Progression of RAS-mutant leukemia during RAF inhibitor treatment. The New England journal of medicine\| PubMed ID: 23134356	2012
Translocation t(11;17) in de novo myelodysplastic syndrome not associated with acute myeloid or acute promyelocytic leukemia. Acta haematologica\| PubMed ID: 23147462	2013
Interpreting new molecular genetics in myelodysplastic syndromes. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program\| PubMed ID: 23233561	2012
Sequential azacitidine plus lenalidomide combination for elderly patients with untreated acute myeloid leukemia. Haematologica\| PubMed ID: 23242596	2013
The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization. The Journal of biological chemistry\| PubMed ID: 23264629	2013
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders. The Journal of experimental medicine\| PubMed ID: 23319699	2013
Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia. Haematologica\| PubMed ID: 23349305	2013
Notch pathway activation targets AML-initiating cell homeostasis and differentiation. The Journal of experimental medicine\| PubMed ID: 23359070	2013
Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia. Nature medicine\| PubMed ID: 23502961	2013
Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression. Cancer cell\| PubMed ID: 23518350	2013
GM-CSF-dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia. Blood\| PubMed ID: 23632888	2013
Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia. Blood\| PubMed ID: 23640996	2013
Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia. Blood\| PubMed ID: 23641016	2013
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer cell\| PubMed ID: 23680150	2013
Importance of genetics in the clinical management of chronic myelomonocytic leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 23690427	2013
Molecular analysis of patients with polycythemia vera or essential thrombocythemia receiving pegylated interferon α-2a. Blood\| PubMed ID: 23782935	2013
Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies. Blood\| PubMed ID: 23926298	2013
Detection of an NRAS mutation in Erdheim-Chester disease. Blood\| PubMed ID: 23929840	2013
Emerging therapeutic paradigms to target the dysregulated Janus kinase/signal transducer and activator of transcription pathway in hematological malignancies. Leukemia & lymphoma\| PubMed ID: 24206094	2014
Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations. The Journal of clinical investigation\| PubMed ID: 24216483	2013
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo. The Journal of experimental medicine\| PubMed ID: 24218140	2013
The importance of subclonal genetic events in MDS. Blood\| PubMed ID: 24263953	2013
Focus on the epigenome in the myeloproliferative neoplasms. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program\| PubMed ID: 24319229	2013
Collaborating constitutive and somatic genetic events in myeloid malignancies: ASXL1 mutations in patients with germline GATA2 mutations. Haematologica\| PubMed ID: 24497555	2014
D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. Genes & development\| PubMed ID: 24589777	2014
Efficacy of intermittent combined RAF and MEK inhibition in a patient with concurrent BRAF- and NRAS-mutant malignancies. Cancer discovery\| PubMed ID: 24589925	2014
Recent discoveries in molecular characterization of acute myeloid leukemia. Current hematologic malignancy reports\| PubMed ID: 24609756	2014
Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis. Blood\| PubMed ID: 24740812	2014
Current pre-clinical and clinical advances in the BCR-ABL1-positive and -negative chronic myeloproliferative neoplasms. Haematologica\| PubMed ID: 24790057	2014
Consensus guidelines for the diagnosis and clinical management of Erdheim-Chester disease. Blood\| PubMed ID: 24850756	2014
Hematopoietic Stem Cell Origin of BRAFV600E Mutations in Hairy Cell Leukemia. Science translational medicine\| PubMed ID: 24871132	2014
Selective activity of the histone deacetylase inhibitor AR-42 against leukemia stem cells: a novel potential strategy in acute myeloid leukemia. Molecular cancer therapeutics\| PubMed ID: 24934933	2014
Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations. Blood\| PubMed ID: 24973361	2014