Elizabeth Jaffee

Department of Oncology, The Johns Hopkins University School of Medicine

Affiliated withThe Johns Hopkins University School of Medicine

Research Area

Biography

Elizabeth Jaffee has not added Biography.
If you are Elizabeth Jaffee and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 118	2014

Other Publications

Article	Year
Aberrant CpG island methylation in cancer cell lines arises in the primary cancers from which they were derived. Oncogene\| PubMed ID: 11960385	2002
Cytokine gene-modified cell-based cancer vaccines. Methods in molecular medicine\| PubMed ID: 11987781	2002
Focus on pancreas cancer. Cancer cell\| PubMed ID: 12150822	2002
Pancreatic cancer. Current problems in cancer\| PubMed ID: 12399802	2002
To live or not to live: that depends on GAGE? Cancer biology & therapy\| PubMed ID: 12432252	2002
Apoptotic, but not necrotic, tumor cell vaccines induce a potent immune response in vivo. International journal of cancer. Journal international du cancer\| PubMed ID: 12455034	2003
Cytokine modified tumor vaccines. Surgical oncology clinics of North America\| PubMed ID: 12487062	2002
Genetically engineered tumor cell vaccine in a head and neck cancer model. The Laryngoscope\| PubMed ID: 12616213	2003
Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays. The American journal of pathology\| PubMed ID: 12651607	2003
Identification and characterization of the immunodominant rat HER-2/neu MHC class I epitope presented by spontaneous mammary tumors from HER-2/neu-transgenic mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12682262	2003
Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy. European journal of immunology\| PubMed ID: 12731050	2003
Lentivirus-mediated gene transfer and expression in established human tumor antigen-specific cytotoxic T cells and primary unstimulated T cells. Human gene therapy\| PubMed ID: 12885348	2003
Spatial distribution of tumor vaccine improves efficacy. The Laryngoscope\| PubMed ID: 12897566	2003
HER-2/neu-specific monoclonal antibodies collaborate with HER-2/neu-targeted granulocyte macrophage colony-stimulating factor secreting whole cell vaccination to augment CD8+ T cell effector... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12902523	2003
Cancer vaccines: an old idea comes of age. Cancer biology & therapy\| PubMed ID: 14508095	2003
Toward a breast cancer vaccine: work in progress. Oncology (Williston Park, N.Y.)\| PubMed ID: 14569849	2003
A phase I vaccine safety and chemotherapy dose-finding trial of an allogeneic GM-CSF-secreting breast cancer vaccine given in a specifically timed sequence with immunomodulatory doses of cyc... Human gene therapy\| PubMed ID: 15018740	2004
Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. The Journal of experimental medicine\| PubMed ID: 15289501	2004
Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice. Oncogene\| PubMed ID: 15489885	2005
Development of a cytokine-modified allogeneic whole cell pancreatic cancer vaccine. Methods in molecular medicine\| PubMed ID: 15542914	2005
Augmenting the potency of breast cancer vaccines: combined modality immunotherapy. Breast disease\| PubMed ID: 15687703	2004
Tumor-specific CD4+ T cells from a patient with renal cell carcinoma recognize diverse shared antigens. International journal of cancer. Journal international du cancer\| PubMed ID: 15704175	2005
Diverse CD8+ T-cell responses to renal cell carcinoma antigens in patients treated with an autologous granulocyte-macrophage colony-stimulating factor gene-transduced renal tumor cell vaccin... Cancer research\| PubMed ID: 15705910	2005
Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response. The Journal of experimental medicine\| PubMed ID: 15883172	2005
Immunotherapy for pancreatic cancer - science driving clinical progress. Nature reviews. Cancer\| PubMed ID: 15905855	2005
Allergies and the risk of pancreatic cancer: a meta-analysis with review of epidemiology and biological mechanisms. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 16103436	2005
Fusion to Listeriolysin O and delivery by Listeria monocytogenes enhances the immunogenicity of HER-2/neu and reveals subdominant epitopes in the FVB/N mouse. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16148111	2005
Leveraging the activity of tumor vaccines with cytotoxic chemotherapy. Cancer research\| PubMed ID: 16166275	2005
Cancer vaccines in combination with multimodality therapy. Cancer treatment and research\| PubMed ID: 16211873	2005
Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology. Molecular cancer therapeutics\| PubMed ID: 16275985	2005
OX40 costimulation synergizes with GM-CSF whole-cell vaccination to overcome established CD8+ T cell tolerance to an endogenous tumor antigen. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16393983	2006
Ductal access for prevention and therapy of mammary tumors. Cancer research\| PubMed ID: 16423990	2006
Mechanisms of immune evasion by tumors. Advances in immunology\| PubMed ID: 16730261	2006
Ectopic expression of vascular cell adhesion molecule-1 as a new mechanism for tumor immune evasion. Cancer research\| PubMed ID: 17308126	2007
Cytogenetic characterization and gene expression profiling in the rat reflux-induced esophageal tumor model. The Journal of thoracic and cardiovascular surgery\| PubMed ID: 17320581	2007
Cancer immunologists and cancer biologists: why we didn't talk then but need to now. Cancer research\| PubMed ID: 17413003	2007
A vascular endothelial growth factor receptor-2 inhibitor enhances antitumor immunity through an immune-based mechanism. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17606729	2007
Alphaviral vector-transduced dendritic cells are successful therapeutic vaccines against neu-overexpressing tumors in wild-type mice. Vaccine\| PubMed ID: 17675184	2007
Vaccine impedes the development of reflux-induced esophageal cancer in a surgical rat model: efficacy of the vaccine in a Pre-Barrett's esophagus setting. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract\| PubMed ID: 17957441	2008
Alteration of cellular and humoral immunity by mutant p53 protein and processed mutant peptide in head and neck cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18056201	2007
Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin. Cancer immunity\| PubMed ID: 18088084	2007
Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: a pilot study of safety... Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18316569	2008
Vaccine impedes the development of reflux-induced esophageal cancer in a surgical rat model: efficacy of the vaccine in a post-Barrett's esophagus setting. Digestive diseases and sciences\| PubMed ID: 18343998	2008
Antibody association with HER-2/neu-targeted vaccine enhances CD8 T cell responses in mice through Fc-mediated activation of DCs. The Journal of clinical investigation\| PubMed ID: 18398507	2008
Analysis of fluorouracil-based adjuvant chemotherapy and radiation after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas: results of a large, prospectively collected databa... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 18640931	2008
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (New York, N.Y.)\| PubMed ID: 18772397	2008
Use of tumour-responsive T cells as cancer treatment. Lancet\| PubMed ID: 19231634	2009
Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science (New York, N.Y.)\| PubMed ID: 19264984	2009
Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer research\| PubMed ID: 19351817	2009
OX40 costimulation can abrogate Foxp3+ regulatory T cell-mediated suppression of antitumor immunity. International journal of cancer. Journal international du cancer\| PubMed ID: 19455675	2009
SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19584151	2009
Timed sequential treatment with cyclophosphamide, doxorubicin, and an allogeneic granulocyte-macrophage colony-stimulating factor-secreting breast tumor vaccine: a chemotherapy dose-ranging ... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 19805669	2009
Paclitaxel enhances early dendritic cell maturation and function through TLR4 signaling in mice. Cellular immunology\| PubMed ID: 20346445	2010
Effective depletion of regulatory T cells allows the recruitment of mesothelin-specific CD8 T cells to the antitumor immune response against a mesothelin-expressing mouse pancreatic adenocar... Clinical and translational science\| PubMed ID: 20357913	2008
Cellular vaccine approaches. Cancer journal (Sudbury, Mass.)\| PubMed ID: 20693840	2010
Tumor antigen-targeted, monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescape. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 20697078	2010
CD8âº Foxp3âº tumor infiltrating lymphocytes accumulate in the context of an effective anti-tumor response. International journal of cancer. Journal international du cancer\| PubMed ID: 20857491	2011
A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A Phase II trial of safety, efficacy, and immune acti... Annals of surgery\| PubMed ID: 21217520	2011
Nondominant CD8 T cells are active players in the vaccine-induced antitumor immune response. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21346233	2011
Review of the 25th annual scientific meeting of the International Society for Biological Therapy of Cancer. Journal of translational medicine\| PubMed ID: 21569425	2011
Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer. PloS one\| PubMed ID: 21572519	2011
Increased expression of DNA repair genes in invasive human pancreatic cancer cells. Pancreas\| PubMed ID: 21633318	2011
A live-attenuated Listeria vaccine (ANZ-100) and a live-attenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: phase I studies of safety and immune induction. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22147941	2012
Defining the critical hurdles in cancer immunotherapy. Journal of translational medicine\| PubMed ID: 22168571	2011
Trafficking of high avidity HER-2/neu-specific T cells into HER-2/neu-expressing tumors after depletion of effector/memory-like regulatory T cells. PloS one\| PubMed ID: 22359647	2012
The determinants of tumour immunogenicity. Nature reviews. Cancer\| PubMed ID: 22378190	2012
Development of a novel preclinical pancreatic cancer research model: bioluminescence image-guided focal irradiation and tumor monitoring of orthotopic xenografts. Translational oncology\| PubMed ID: 22496923	2012
Whole cell vaccines--past progress and future strategies. Seminars in oncology\| PubMed ID: 22595050	2012
Annexin A2 is a new antigenic target for pancreatic cancer immunotherapy. Oncoimmunology\| PubMed ID: 22720228	2012
Regulatory T-cell modulation using cyclophosphamide in vaccine approaches: a current perspective. Cancer research\| PubMed ID: 22761338	2012
Concomitant targeting of tumor cells and induction of T-cell response synergizes to effectively inhibit trastuzumab-resistant breast cancer. Cancer research\| PubMed ID: 22773664	2012
Rapid characterization of candidate biomarkers for pancreatic cancer using cell microarrays (CMAs). Journal of proteome research\| PubMed ID: 22985314	2012
Effects of genomic changes in hepatitis B virus on postoperative recurrence and survival in patients with hepatocellular carcinoma. Annals of surgical oncology\| PubMed ID: 23104706	2013
Targeting the right regulatory T-cell population for tumor immunotherapy. Oncoimmunology\| PubMed ID: 23170276	2012
Vaccines for pancreatic cancer. Cancer journal (Sudbury, Mass.)\| PubMed ID: 23187853	2012
Personalized chemotherapy profiling using cancer cell lines from selectable mice. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23340293	2013
Development of a cytokine-modified allogeneic whole cell pancreatic cancer vaccine. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23359154	2013
Evaluation of predictive variables in locally advanced pancreatic adenocarcinoma patients receiving definitive chemoradiation. Practical radiation oncology\| PubMed ID: 23585823	2012
Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma. Gastroenterology\| PubMed ID: 23622132	2013
Immunotherapy in preneoplastic disease: targeting early procarcinogenic inflammatory changes that lead to immune suppression and tumor tolerance. Annals of the New York Academy of Sciences\| PubMed ID: 23651188	2013
Women in oncology: progress, challenges, and keys to success. American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting\| PubMed ID: 23714569	2013
Next-generation cancer vaccine approaches: integrating lessons learned from current successes with promising biotechnologic advances. Journal of the National Comprehensive Cancer Network : JNCCN\| PubMed ID: 23847215	2013
Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 23924790	2013
Low total lymphocyte count is associated with poor survival in patients with resected pancreatic adenocarcinoma receiving a GM-CSF secreting pancreatic tumor vaccine. Annals of surgical oncology\| PubMed ID: 24046118	2013
Harnessing immune responses in the tumor microenvironment: all signals needed. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 24097857	2013
Peptidases released by necrotic cells control CD8+ T cell cross-priming. The Journal of clinical investigation\| PubMed ID: 24216478	2013
Mapping patterns of local recurrence after pancreaticoduodenectomy for pancreatic adenocarcinoma: a new approach to adjuvant radiation field design. International journal of radiation oncology, biology, physics\| PubMed ID: 24267969	2013
Tumor immunology: multidisciplinary science driving basic and clinical advances. Cancer immunology research\| PubMed ID: 24409447	2013
Vaccine therapy for pancreatic cancer. Oncoimmunology\| PubMed ID: 24498551	2013
Fusion protein of mutant B7-DC and Fc enhances the antitumor immune effect of GM-CSF-secreting whole-cell vaccine. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 24598447	2014
A Listeria vaccine and depletion of T-regulatory cells activate immunity against early stage pancreatic intraepithelial neoplasms and prolong survival of mice. Gastroenterology\| PubMed ID: 24607504	2014
Apoptosis-regulated low-avidity cancer-specific CD8(+) T cells can be rescued to eliminate HER2/neu-expressing tumors by costimulatory agonists in tolerized mice. Cancer immunology research\| PubMed ID: 24764578	2014
Can we predict mutant neoepitopes in human cancers for patient-specific vaccine therapy? Cancer immunology research\| PubMed ID: 24795140	2014
Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia. Cancer cell\| PubMed ID: 24823639	2014
Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival. International journal of cancer. Journal international du cancer\| PubMed ID: 24832153	2014
Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation. Cancer immunology research\| PubMed ID: 24942756	2014
A Safety and Feasibility Study of an Allogeneic Colon Cancer Cell Vaccine Administered with a Granulocyte-Macrophage Colony Stimulating Factor-Producing Bystander Cell Line in Patients with ... Annals of surgical oncology\| PubMed ID: 24943235	2014
Immunobiology of radiotherapy: new paradigms. Radiation research\| PubMed ID: 25036983	2014
PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition. The Journal of pathology\| PubMed ID: 25074413	2014
A Feasibility Study of Cyclophosphamide, Trastuzumab, and an Allogeneic GM-CSF-Secreting Breast Tumor Vaccine for HER2+ Metastatic Breast Cancer. Cancer immunology research\| PubMed ID: 25116755	2014