Bon-Kyoung Koo

Department of Genetics, University of Cambridge

Affiliated withUniversity of Cambridge Institute for Basic Science

Research Area

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 40	2014
Publication title Cited by 17	2017
Publication title Cited by 1	2025

Other Publications

Article	Year
Controlled gene expression in primary Lgr5 organoid cultures. Nature methods\| PubMed ID: 22138822	2012
Mind bomb-2 is an E3 ligase for Notch ligand. The Journal of biological chemistry\| PubMed ID: 15824097	2005
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch. Development (Cambridge, England)\| PubMed ID: 16000382	2005
Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2. Molecular and cellular biology\| PubMed ID: 16428453	2006
Snx5, as a Mind bomb-binding protein, is expressed in hematopoietic and endothelial precursor cells in zebrafish. FEBS letters\| PubMed ID: 16857196	2006
Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1. The Journal of biological chemistry\| PubMed ID: 17003037	2006
An obligatory role of mind bomb-1 in notch signaling of mammalian development. PloS one\| PubMed ID: 18043734	2007
Crif1 is a novel transcriptional coactivator of STAT3. The EMBO journal\| PubMed ID: 18200042	2008
A crucial role of WW45 in developing epithelial tissues in the mouse. The EMBO journal\| PubMed ID: 18369314	2008
Mind bomb 1-expressing intermediate progenitors generate notch signaling to maintain radial glial cells. Neuron\| PubMed ID: 18498734	2008
Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches. Molecular and cellular biology\| PubMed ID: 18505817	2008
Defective Notch activation in microenvironment leads to myeloproliferative disease. Blood\| PubMed ID: 18818392	2008
Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development. The Journal of experimental medicine\| PubMed ID: 18824586	2008
Notch signaling promotes the generation of EphrinB1-positive intestinal epithelial cells. Gastroenterology\| PubMed ID: 19332065	2009
Essential role of CR6-interacting factor 1 (Crif1) in E74-like factor 3 (ELF3)-mediated intestinal development. The Journal of biological chemistry\| PubMed ID: 19801644	2009
Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. The Journal of clinical investigation\| PubMed ID: 19855135	2009
The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells. The Journal of clinical investigation\| PubMed ID: 21540552	2011
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature\| PubMed ID: 21727895	2011
Survival and differentiation of mammary epithelial cells in mammary gland development require nuclear retention of Id2 due to RANK signaling. Molecular and cellular biology\| PubMed ID: 21947283	2011
A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal. Molecular and cellular biology\| PubMed ID: 22393260	2012
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. The EMBO journal\| PubMed ID: 22692129	2012
Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer. The Journal of clinical investigation\| PubMed ID: 22863622	2012
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature\| PubMed ID: 22895187	2012
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell reports\| PubMed ID: 23545496	2013
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell\| PubMed ID: 24120136	2013
Generation of BAC transgenic epithelial organoids. PloS one\| PubMed ID: 24204693	2013
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell stem cell\| PubMed ID: 24315439	2013
Retroviral gene expression control in primary organoid cultures. Current protocols in stem cell biology\| PubMed ID: 24510288	2013
Stem Cells Marked by the R-Spondin Receptor LGR5. Gastroenterology\| PubMed ID: 24859206	2014
Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts. Cell stem cell\| PubMed ID: 25620640	2015
Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26023187	2015
Modeling mouse and human development using organoid cultures. Development (Cambridge, England)\| PubMed ID: 26395140	2015
Adult stem cell lineage tracing and deep tissue imaging. BMB reports\| PubMed ID: 26634741	2015
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation. Nature protocols\| PubMed ID: 27560176	2016
Clonal Evolution of Stem Cells in the Gastrointestinal Tract. Advances in experimental medicine and biology\| PubMed ID: 27573765	2016
Organoids: A new in vitro model system for biomedical science and disease modelling and promising source for cell-based transplantation. Developmental biology\| PubMed ID: 27983962	2016
Simultaneous paralogue knockout using a CRISPR-concatemer in mouse small intestinal organoids. Developmental biology\| PubMed ID: 27983963	2016
Adult gastric stem cells and their niches. Wiley interdisciplinary reviews. Developmental biology\| PubMed ID: 28044412	2017
One-step generation of conditional and reversible gene knockouts. Nature methods\| PubMed ID: 28135257	2017
Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium. Nature cell biology\| PubMed ID: 28394884	2017
Stem Cells in Repair of Gastrointestinal Epithelia. Physiology (Bethesda, Md.)\| PubMed ID: 28615312	2017
Organoid Studies in COVID-19 Research. International journal of stem cells\| PubMed ID: 35220288	2022
p57 imposes the reserve stem cell state of gastric chief cells. Cell stem cell\| PubMed ID: 35523142	2022
Sensitivity towards HDAC inhibition is associated with RTK/MAPK pathway activation in gastric cancer. EMBO molecular medicine\| PubMed ID: 35993110	2022
Clone wars: From molecules to cell competition in intestinal stem cell homeostasis and disease. Experimental & molecular medicine\| PubMed ID: 36117218	2022
SCON-a Short Conditional intrON for conditional knockout with one-step zygote injection. Experimental & molecular medicine\| PubMed ID: 36494589	2022
A cellular hierarchy of Notch and Kras signaling controls cell fate specification in the developing mouse salivary gland. Developmental cell\| PubMed ID: 36693323	2023
Author Correction: SCON-a Short Conditional intrON for conditional knockout with one-step zygote injection. Experimental & molecular medicine\| PubMed ID: 37340143	2023
Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet. Scientific reports\| PubMed ID: 37633982	2023
NOTCH3 signalling controls human trophoblast stem cell expansion and differentiation. Development (Cambridge, England)\| PubMed ID: 37905445	2023
Partial in vivo reprogramming enables injury-free intestinal regeneration via autonomous induction. Science advances\| PubMed ID: 38000027	2023
Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2. Science advances\| PubMed ID: 38000028	2023
Red2Flpe-SCON: a versatile, multicolor strategy for generating mosaic conditional knockout mice. Nature communications\| PubMed ID: 38862535	2024
Dual function of PHF16 in reinstating homeostasis of murine intestinal epithelium after crypt regeneration. Developmental cell\| PubMed ID: 39232563	2024
Long-term three-dimensional high-resolution imaging of live unlabeled small intestinal organoids via low-coherence holotomography. Experimental & molecular medicine\| PubMed ID: 39349827	2024
Gonadal sex reversal at single-cell resolution in Znrf3-deficient mice. Development (Cambridge, England)\| PubMed ID: 39629665	2024
RANK drives structured intestinal epithelial expansion during pregnancy. Nature\| PubMed ID: 39633049	2025
Transcriptomic Analysis of Air-Liquid Interface Culture in Human Lung Organoids Reveals Regulators of Epithelial Differentiation. Cells\| PubMed ID: 39682739	2024
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation. Cell stem cell\| PubMed ID: 39978341	2025
Evolution of organoid genetics. European journal of cell biology\| PubMed ID: 40056574	2025
Navigating ethical challenges across professions: Insights from an Ethics Lab on patient-derived organoids. Med (New York, N.Y.)\| PubMed ID: 40300609	2025
Diverse bat organoids provide pathophysiological models for zoonotic viruses. Science (New York, N.Y.)\| PubMed ID: 40373131	2025
Flagellin sensing, signaling, and immune responses in plants. Plant communications\| PubMed ID: 40400167	2025