Nicholas J. Harmer

Department of Biosciences, University of Exeter

Affiliated withUniversity of Exeter

Research Area

Biography

Nicholas J. Harmer has not added Biography.
If you are Nicholas J. Harmer and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 142	2014

Other Publications

Article	Year
A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens. Blood\| PubMed ID: 11861285	2002
The structural biology of growth factor receptor activation. Biophysical chemistry\| PubMed ID: 12646390	2003
The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. Biochemistry\| PubMed ID: 14730967	2004
Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)-FGF receptor-heparin complex. Journal of molecular biology\| PubMed ID: 15165853	2004
1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family. FEBS letters\| PubMed ID: 15710406	2005
Cooperative dimerization of fibroblast growth factor 1 (FGF1) upon a single heparin saccharide may drive the formation of 2:2:1 FGF1.FGFR2c.heparin ternary complexes. The Journal of biological chemistry\| PubMed ID: 16219767	2005
Multimers of the fibroblast growth factor (FGF)-FGF receptor-saccharide complex are formed on long oligomers of heparin. The Biochemical journal\| PubMed ID: 16223363	2006
Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 16524830	2006
Expression and purification of recombinant human fibroblast growth factor receptor in Escherichia coli. Protein expression and purification\| PubMed ID: 16750394	2006
Cloning, expression, purification and preliminary crystallographic analysis of the short-chain dehydrogenase enzymes WbmF, WbmG and WbmH from Bordetella bronchiseptica. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 17671375	2007
Predicting protein function from structure--the roles of short-chain dehydrogenase/reductase enzymes in Bordetella O-antigen biosynthesis. Journal of molecular biology\| PubMed ID: 17950751	2007
Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms. The Journal of biological chemistry\| PubMed ID: 18281281	2008
The structure of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei reveals a zinc binding site at the heart of the active site. Journal of molecular biology\| PubMed ID: 20447408	2010
The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development. The Biochemical journal\| PubMed ID: 21574961	2011
A novel FK-506-binding-like protein that lacks peptidyl-prolyl isomerase activity is involved in intracellular infection and in vivo virulence of Burkholderia pseudomallei. Microbiology (Reading, England)\| PubMed ID: 21680634	2011
A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on virulence. Infection and immunity\| PubMed ID: 21859853	2011
Myosin-5, kinesin-1 and myosin-17 cooperate in secretion of fungal chitin synthase. The EMBO journal\| PubMed ID: 22027862	2012
A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrobial agents and chemotherapy\| PubMed ID: 24366729	2014
Structural insights into WcbI, a novel polysaccharide-biosynthesis enzyme. IUCrJ\| PubMed ID: 25075317	2014