Stephan E. Lehnart

Heart Research Center Goettingen

Affiliated withHeart Research Center Goettingen University Medical Center Goettingen German Center for Cardiovascular Research (DZHK) partner site Goettingen

Research Area

Bioengineering

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 45	2014

Other Publications

Article	Year
Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium. Cardiovascular research\| PubMed ID: 11744019	2002
Intracellular beta-blockade: overexpression of Galpha(i2) depresses the beta-adrenergic response in intact myocardium. Cardiovascular research\| PubMed ID: 12123769	2002
Coronary perfusion cocktails for in vivo gene transfer. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 12597011	2003
PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure. The Journal of cell biology\| PubMed ID: 12629052	2003
FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell\| PubMed ID: 12837242	2003
Immunophilins and coupled gating of ryanodine receptors. Current topics in medicinal chemistry\| PubMed ID: 12871170	2003
Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circulation research\| PubMed ID: 15016728	2004
Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science (New York, N.Y.)\| PubMed ID: 15073377	2004
Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation\| PubMed ID: 15197150	2004
Cardiac ryanodine receptor function and regulation in heart disease. Annals of the New York Academy of Sciences\| PubMed ID: 15201156	2004
Calstabin deficiency, ryanodine receptors, and sudden cardiac death. Biochemical and biophysical research communications\| PubMed ID: 15336974	2004
Intracellular calcium release and cardiac disease. Annual review of physiology\| PubMed ID: 15709953	2005
Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation\| PubMed ID: 15851612	2005
Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15972811	2005
Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure. Circulation\| PubMed ID: 15983258	2005
Ryanodine receptor-targeted anti-arrhythmic therapy. Annals of the New York Academy of Sciences\| PubMed ID: 16093511	2005
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell\| PubMed ID: 16213210	2005
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16407108	2006
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16672364	2006
Phosphodiesterase 4D and heart failure: a cautionary tale. Expert opinion on therapeutic targets\| PubMed ID: 16981825	2006
Novel targets for treating heart and muscle disease: stabilizing ryanodine receptors and preventing intracellular calcium leak. Current opinion in pharmacology\| PubMed ID: 17306622	2007
Modulation of the ryanodine receptor and intracellular calcium. Annual review of biochemistry\| PubMed ID: 17506640	2007
Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeut... Circulation\| PubMed ID: 17998470	2007
Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18268335	2008
Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. The Journal of clinical investigation\| PubMed ID: 18483626	2008
Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology\| PubMed ID: 18515204	2008
Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins. Human molecular genetics\| PubMed ID: 18927124	2009
Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart. Heart failure reviews\| PubMed ID: 19434491	2009
K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic research in cardiology\| PubMed ID: 19718543	2010
An antidote for calcium leak: targeting molecular arrhythmia mechanisms. Journal of molecular and cellular cardiology\| PubMed ID: 19931542	2010
Differential cardiac remodeling in preload versus afterload. Circulation\| PubMed ID: 20733099	2010
Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. The Journal of clinical investigation\| PubMed ID: 21099118	2010
SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes. Circulation research\| PubMed ID: 21164104	2011
Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolariz... Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology\| PubMed ID: 22117037	2012
Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion. Cardiovascular research\| PubMed ID: 22411973	2012
Stimulated emission depletion live-cell super-resolution imaging shows proliferative remodeling of T-tubule membrane structures after myocardial infarction. Circulation research\| PubMed ID: 22723297	2012
Understanding the physiology of heart failure through cellular and in vivo models-towards targeting of complex mechanisms. Experimental physiology\| PubMed ID: 23064508	2013
Superresolution microscopy in heart - cardiac nanoscopy. Journal of molecular and cellular cardiology\| PubMed ID: 23219451	2013
Imaging T-tubules: dynamic membrane structures for deep functions. Cardiovascular research\| PubMed ID: 23504549	2013
Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes. Journal of cell science\| PubMed ID: 24569881	2014
Transgenic mice for real-time visualization of cGMP in intact adult cardiomyocytes. Circulation research\| PubMed ID: 24599804	2014
Toward panoramic in situ mapping of action potential propagation in transgenic hearts to investigate initiation and therapeutic control of arrhythmias. Frontiers in physiology\| PubMed ID: 25249982	2014