Akira Sawa

Department of Psychiatry, Johns Hopkins University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 14	2014

Other Publications

Article	Year
Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. Human molecular genetics\| PubMed ID: 18469341	2008
Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nature cell biology\| PubMed ID: 18552833	2008
Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. Archives of general psychiatry\| PubMed ID: 18762586	2008
Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (gad) mouse. Neurochemistry international\| PubMed ID: 19154771	2009
Peripheral olfactory system for clinical and basic psychiatry: a promising entry point to the mystery of brain mechanism and biomarker identification in schizophrenia. The American journal of psychiatry\| PubMed ID: 19188289	2009
Schizophrenia and epilepsy: is there a shared susceptibility? Neuroscience research\| PubMed ID: 19367784	2009
Animal models of gene-environment interactions in schizophrenia. Behavioural brain research\| PubMed ID: 19379776	2009
GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron\| PubMed ID: 19607794	2009
Using bioinformatic tools. The American journal of psychiatry\| PubMed ID: 19651749	2009
Cortical development and glutamatergic dysregulation in schizophrenia. Biological psychiatry\| PubMed ID: 19712774	2009
Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. Trends in neurosciences\| PubMed ID: 19712980	2009
Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood. Behavioural brain research\| PubMed ID: 19716847	2010
A novel role for hGas7b in microtubular maintenance: possible implication in tau-associated pathology in Alzheimer disease. The Journal of biological chemistry\| PubMed ID: 19801671	2009
Negative symptoms of schizophrenia correlate with impairment on the University of Pennsylvania smell identification test. Neuroscience research\| PubMed ID: 19819272	2010
Understanding the role of DISC1 in psychiatric disease and during normal development. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19828788	2009
Glyceraldehyde-3-phosphate dehydrogenase aggregate formation participates in oxidative stress-induced cell death. The Journal of biological chemistry\| PubMed ID: 19837666	2009
Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models. Schizophrenia bulletin\| PubMed ID: 19903746	2010
Preface. This volume focuses on how genetic models for schizophrenia, that is, manipulation in genetic susceptibility factors for the disease, have potential in opening a new window of bette... Progress in brain research\| PubMed ID: 19932335	2009
A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage. Biological psychiatry\| PubMed ID: 20022592	2010
Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nature neuroscience\| PubMed ID: 20139976	2010
Neuroanatomic and cognitive abnormalities related to herpes simplex virus type 1 in schizophrenia. Schizophrenia research\| PubMed ID: 20153952	2010
Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits. Neuron\| PubMed ID: 20188653	2010
Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20212127	2010
Genetic animal models for schizophrenia: advantages and limitations of genetic manipulation in drosophila, zebrafish, rodents, and primates. Progress in brain research\| PubMed ID: 20302812	2009
Disturbed synaptic connectivity in schizophrenia: convergence of genetic risk factors during neurodevelopment. Brain research bulletin\| PubMed ID: 20433911	2010
Gray-matter abnormalities in deficit schizophrenia. Schizophrenia research\| PubMed ID: 20452187	2010
Assessing the role of endooligopeptidase activity of Ndel1 (nuclear-distribution gene E homolog like-1) in neurite outgrowth. Molecular and cellular neurosciences\| PubMed ID: 20462516	2010
Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20685985	2010
The diverse functions of GAPDH: views from different subcellular compartments. Cellular signalling\| PubMed ID: 20727968	2011
Nitric oxide signaling and nitrosative stress in neurons: role for S-nitrosylation. Antioxidants & redox signaling\| PubMed ID: 20812870	2011
A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder: altered l-serine level associated with disruption of PSAT1 gene expressi... Neuroscience research\| PubMed ID: 20955740	2011
Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology. Biological psychiatry\| PubMed ID: 21130225	2010
Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21436042	2011
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature\| PubMed ID: 21471969	2011
Working memory deficits in neuronal nitric oxide synthase knockout mice: potential impairments in prefrontal cortex mediated cognitive function. Biochemical and biophysical research communications\| PubMed ID: 21539806	2011
Glutathione is a physiologic reservoir of neuronal glutamate. Biochemical and biophysical research communications\| PubMed ID: 21539809	2011
In utero electroporation as a tool for genetic manipulation in vivo to study psychiatric disorders: from genes to circuits and behaviors. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry\| PubMed ID: 21551077	2012
Inositol hexakisphosphate kinases induce cell death in Huntington disease. The Journal of biological chemistry\| PubMed ID: 21652713	2011
Readdressing synaptic pruning theory for schizophrenia: Combination of brain imaging and cell biology. Communicative & integrative biology\| PubMed ID: 21655443	2011
DISC1 regulates synaptic vesicle transport via a lithium-sensitive pathway. Neuroscience research\| PubMed ID: 21664390	2011
Mouse strain differences in phencyclidine-induced behavioural changes. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)\| PubMed ID: 21733237	2012
Altered MHC class I expression in dorsolateral prefrontal cortex of nonsmoker patients with schizophrenia. Neuroscience research\| PubMed ID: 21801761	2011
Protein S-nitrosylation: role for nitric oxide signaling in neuronal death. Biochimica et biophysica acta\| PubMed ID: 21803124	2012
Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment. Behavioural brain research\| PubMed ID: 21835207	2011
The insula-claustrum region and delusions in schizophrenia. Schizophrenia research\| PubMed ID: 21875780	2011
Better understanding of mechanisms of schizophrenia and bipolar disorder: from human gene expression profiles to mouse models. Neurobiology of disease\| PubMed ID: 21914480	2012
Human nasal olfactory epithelium as a dynamic marker for CNS therapy development. Experimental neurology\| PubMed ID: 21945230	2011
DISC1 at 10: connecting psychiatric genetics and neuroscience. Trends in molecular medicine\| PubMed ID: 22015021	2011
Advancing drug discovery for schizophrenia. Annals of the New York Academy of Sciences\| PubMed ID: 22032400	2011
Following the genes: a framework for animal modeling of psychiatric disorders. BMC biology\| PubMed ID: 22078115	2011
Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nature reviews. Neuroscience\| PubMed ID: 22095064	2011
Anti-/Propsychotic drug signaling via heteromeric GPCRs--a balancing act? Cell\| PubMed ID: 22118451	2011
Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5. Biochemical and biophysical research communications\| PubMed ID: 22445894	2012
KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant. Nature\| PubMed ID: 22596160	2012
Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits. Human molecular genetics\| PubMed ID: 22798627	2012
Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 22837388	2012
PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome. The Journal of cell biology\| PubMed ID: 22908311	2012
Diabetes is associated with lower global cognitive function in schizophrenia. Schizophrenia research\| PubMed ID: 23031192	2012
DISC1 as a therapeutic target for mental illnesses. Expert opinion on therapeutic targets\| PubMed ID: 23130881	2012
DISC1: a key lead in studying cortical development and associated brain disorders. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry\| PubMed ID: 23300216	2013
Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging. Human molecular genetics\| PubMed ID: 23314019	2013
Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science (New York, N.Y.)\| PubMed ID: 23329051	2013
Synapse-specific contributions in the cortical pathology of schizophrenia. Neurobiology of disease\| PubMed ID: 23336981	2013
Schizophrenia research in 2013: are we making progress? Neurobiology of disease\| PubMed ID: 23380149	2013
Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice. Glia\| PubMed ID: 23382131	2013
MicroRNA-382 expression is elevated in the olfactory neuroepithelium of schizophrenia patients. Neurobiology of disease\| PubMed ID: 23542694	2013
Mouse models of gene-environment interactions in schizophrenia. Neurobiology of disease\| PubMed ID: 23748077	2013
Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23840059	2013
Cuprizone short-term exposure: astrocytic IL-6 activation and behavioral changes relevant to psychosis. Neurobiology of disease\| PubMed ID: 23867234	2013
Relationships between serum leptin level and severity of positive symptoms in schizophrenia. Neuroscience research\| PubMed ID: 23896201	2013
Regulation of N-Methyl-D-Aspartate Receptors by Disrupted-in-Schizophrenia-1. Biological psychiatry\| PubMed ID: 23906531	2013
Reduced anterior cingulate gray matter volume and thickness in subjects with deficit schizophrenia. Schizophrenia research\| PubMed ID: 24035178	2013
Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24101523	2013
Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: utility and limitation of the surrogate tissues in research for brain disorders. Neuroscience research\| PubMed ID: 24120685	2013
Hippocampal volume reduction correlates with apathy in traumatic brain injury, but not schizophrenia. The Journal of neuropsychiatry and clinical neurosciences\| PubMed ID: 24247856	2013
Modeling heterogeneous patients with a clinical diagnosis of schizophrenia with induced pluripotent stem cells. Biological psychiatry\| PubMed ID: 24331955	2014
Promoting careers in academic research to psychiatry residents. Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry\| PubMed ID: 24497181	2014
Regional brain distribution of translocator protein using [(11)C]DPA-713 PET in individuals infected with HIV. Journal of neurovirology\| PubMed ID: 24567030	2014
Oxidative stress and schizophrenia: recent breakthroughs from an old story. Current opinion in psychiatry\| PubMed ID: 24613987	2014
PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24706880	2014
Reasons for not seeking general medical care among individuals with serious mental illness. Psychiatric services (Washington, D.C.)\| PubMed ID: 24733659	2014
Inflammatory molecular signature associated with infectious agents in psychosis. Schizophrenia bulletin\| PubMed ID: 24743863	2014
Human stem cells and surrogate tissues for basic and translational study of mental disorders. Biological psychiatry\| PubMed ID: 24862565	2014
Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1. Human molecular genetics\| PubMed ID: 24934694	2014
Is prophylactic psychiatry around the corner? combating adolescent oxidative stress for adult psychosis and schizophrenia. Neuron\| PubMed ID: 25189204	2014
Role of Apoptosis Signal-regulating Kinase 1 (ASK1) as an activator of the GAPDH-Siah1 Stress-Signaling Cascade. The Journal of biological chemistry\| PubMed ID: 25391652	2014
Environmental Stresso, rs and Epigenetic Control of the Hypothalamic-Pituitary-Adrenal-Axis (HPA-axis). Neuroendocrinology\| PubMed ID: 25427939	2014