Todd E. Golde

Department of Neuroscience, University of Florida

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 264	2014

Other Publications

Article	Year
Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiology of disease\| PubMed ID: 11848681	2002
A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch. Neurobiology of disease\| PubMed ID: 11895378	2002
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11917117	2002
FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants. Biochimica et biophysica acta\| PubMed ID: 11959461	2002
Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11972038	2002
Identification of a novel family of presenilin homologues. Human molecular genetics\| PubMed ID: 11978763	2002
Inflammation takes on Alzheimer disease. Nature medicine\| PubMed ID: 12205453	2002
Open peer commentary regarding Abeta immunization and CNS inflammation by Pasinetti et al. Neurobiology of aging\| PubMed ID: 12392769	2002
Alzheimer disease therapy: can the amyloid cascade be halted? The Journal of clinical investigation\| PubMed ID: 12511580	2003
Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis. Science's STKE : signal transduction knowledge environment\| PubMed ID: 12621149	2003
Overexpression of nicastrin increases Abeta production. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12692078	2003
Peptide-based, irreversible inhibitors of gamma-secretase activity. Biochemical and biophysical research communications\| PubMed ID: 12763025	2003
Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular d... The Journal of biological chemistry\| PubMed ID: 12777371	2003
The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce... The Journal of biological chemistry\| PubMed ID: 12805355	2003
Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. The Journal of biological chemistry\| PubMed ID: 12805356	2003
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron\| PubMed ID: 12895417	2003
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. The Journal of clinical investigation\| PubMed ID: 12897211	2003
Immune responses against Abeta1-42 in HLA class II transgenic mice: implications for Abeta1-42 immune-mediated therapies. Neurobiology of aging\| PubMed ID: 12928057	2003
TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12960327	2003
Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs. Human molecular genetics\| PubMed ID: 12966028	2003
Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 13679422	2003
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor. The Journal of biological chemistry\| PubMed ID: 14704149	2004
A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active ... The Journal of biological chemistry\| PubMed ID: 15252014	2004
Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity. Biochemical and biophysical research communications\| PubMed ID: 15336962	2004
Homing in on intracellular Abeta? Neuron\| PubMed ID: 15748837	2005
The Abeta hypothesis: leading us to rationally-designed therapeutic strategies for the treatment or prevention of Alzheimer disease. Brain pathology (Zurich, Switzerland)\| PubMed ID: 15779241	2005
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nature medicine\| PubMed ID: 15834426	2005
Bringing amyloid into focus. Nature biotechnology\| PubMed ID: 15877070	2005
Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene\| PubMed ID: 15940249	2005
Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nature immunology\| PubMed ID: 15991363	2005
Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42. Journal of neurochemistry\| PubMed ID: 16300630	2006
C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation. Journal of neurochemistry\| PubMed ID: 16305624	2006
Notch1 augments NF-kappaB activity by facilitating its nuclear retention. The EMBO journal\| PubMed ID: 16319921	2006
Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16325474	2006
Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. The Journal of clinical investigation\| PubMed ID: 16341263	2006
Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy. Biochemical and biophysical research communications\| PubMed ID: 16376853	2006
Inclusion-body myositis and Alzheimer disease: two sides of the same coin, or different currencies altogether? Neurology\| PubMed ID: 16432148	2006
Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs. Biochemistry\| PubMed ID: 16834339	2006
Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Abeta immunotherapy. Journal of neuroinflammation\| PubMed ID: 16872492	2006
Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 16873890	2006
Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates. Molecular neurodegeneration\| PubMed ID: 16930450	2006
Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 17068112	2006
Disease modifying therapy for AD? Journal of neurochemistry\| PubMed ID: 17076654	2006
Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells. Molecular neurodegeneration\| PubMed ID: 17105660	2006
Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid prec... The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17108166	2006
Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease. Current Alzheimer research\| PubMed ID: 17168641	2006
The pathogenesis of Alzheimer's disease and the role of Abeta42. CNS spectrums\| PubMed ID: 17192766	2007
Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Abeta levels. Molecular neurodegeneration\| PubMed ID: 17559680	2007
Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-kappaB signaling. Molecular cancer therapeutics\| PubMed ID: 17604336	2007
Statins reduce amyloid-beta production through inhibition of protein isoprenylation. The Journal of biological chemistry\| PubMed ID: 17646164	2007
Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC neuroscience\| PubMed ID: 17650315	2007
Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. The Journal of biological chemistry\| PubMed ID: 17827153	2007
Off the beaten pathway: the complex cross talk between Notch and NF-kappaB. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 18059366	2008
Notch signaling is activated by TLR stimulation and regulates macrophage functions. European journal of immunology\| PubMed ID: 18085664	2008
Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. Alzheimer disease and associated disorders\| PubMed ID: 18090435	2007
Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage. Current topics in medicinal chemistry\| PubMed ID: 18220932	2008
Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase. The Journal of biological chemistry\| PubMed ID: 18426795	2008
Using leucine zipper to facilitate alpha-synuclein assembly. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 18492724	2008
BRI2 (ITM2b) inhibits Abeta deposition in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18524908	2008
Substrate-targeting gamma-secretase modulators. Nature\| PubMed ID: 18548070	2008
Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood\| PubMed ID: 18550850	2008
Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. Blood\| PubMed ID: 19001083	2009
"What kills neurons in neurodegenerative diseases?", a review series in an open access journal. Molecular neurodegeneration\| PubMed ID: 19193221	2009
The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease. Molecular neurodegeneration\| PubMed ID: 19193222	2009
Notch regulates cytolytic effector function in CD8+ T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19265115	2009
Quantitative and mechanistic studies of Abeta immunotherapy. CNS & neurological disorders drug targets\| PubMed ID: 19275635	2009
Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells. Cancer research\| PubMed ID: 19276374	2009
Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiology of disease\| PubMed ID: 19320056	2009
A small molecule inhibitor of signal peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity. PloS one\| PubMed ID: 19337374	2009
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19383787	2009
Medicine. Avoiding unintended toxicity. Science (New York, N.Y.)\| PubMed ID: 19407192	2009
Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575. Molecular neurodegeneration\| PubMed ID: 19419556	2009
Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins. Seminars in cell & developmental biology\| PubMed ID: 19429495	2009
Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19638957	2009
Targeting Abeta and tau in Alzheimer's disease, an early interim report. Experimental neurology\| PubMed ID: 19716367	2010
Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nature neuroscience\| PubMed ID: 19734892	2009
An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1. Biochemistry\| PubMed ID: 19821615	2009
Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases. Alzheimer's research & therapy\| PubMed ID: 19822029	2009
Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 19825975	2010
IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20368278	2010
Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain. Journal of neuroscience methods\| PubMed ID: 20951738	2010
Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation. Anticancer research\| PubMed ID: 21036696	2010
Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21084594	2010
Sorting out frontotemporal dementia? Neuron\| PubMed ID: 21092851	2010
Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21123562	2010
Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift. Neuron\| PubMed ID: 21262461	2011
Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo. Molecular neurodegeneration\| PubMed ID: 21324189	2011
Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21411653	2011
Right sizing funding for Alzheimer's disease. Alzheimer's research & therapy\| PubMed ID: 21554753	2011
Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification. Nature neuroscience\| PubMed ID: 21572432	2011
Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulatio... The Journal of biological chemistry\| PubMed ID: 21868378	2011
Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein. The Journal of biological chemistry\| PubMed ID: 21868380	2011
Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization. PloS one\| PubMed ID: 22069482	2011
Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice. Molecular neurodegeneration\| PubMed ID: 22222029	2012
Shifting a complex debate on γ-secretase cleavage and Alzheimer's disease. The EMBO journal\| PubMed ID: 22505028	2012
Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains. Alzheimer's research & therapy\| PubMed ID: 22621179	2012
Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition. Molecular neurodegeneration\| PubMed ID: 22838967	2012
Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology. Molecular neurodegeneration\| PubMed ID: 22892055	2012
Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22895721	2012
Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo. Nature communications\| PubMed ID: 22910355	2012
5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease. Annals of neurology\| PubMed ID: 23034916	2012
Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-Î² (AÎ²) production by altering trafficking of Î³-secretase and amyloid precursor protein (APP). The Journal of biological chemistry\| PubMed ID: 23043097	2012
Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases. Journal of medicinal chemistry\| PubMed ID: 23181502	2012
Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23236186	2012
Analysis of proteolytic processes and enzymatic activities in the generation of huntingtin n-terminal fragments in an HEK293 cell model. PloS one\| PubMed ID: 23236391	2012
Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo. The European journal of neuroscience\| PubMed ID: 23347239	2013
Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23447589	2013
Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems. Alzheimer's research & therapy\| PubMed ID: 23470193	2013
Thinking laterally about neurodegenerative proteinopathies. The Journal of clinical investigation\| PubMed ID: 23635781	2013
Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy. Acta neuropathologica\| PubMed ID: 23666556	2013
Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease. Alzheimer's research & therapy\| PubMed ID: 23692967	2013
Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (New York, N.Y.)\| PubMed ID: 23704553	2013
Conformational templating of α-synuclein aggregates in neuronal-glial cultures. Molecular neurodegeneration\| PubMed ID: 23714769	2013
Steroids as γ-secretase modulators. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 23716494	2013
Progress in Alzheimer's disease research circa 2013: Is the glass half empty or half full? Alzheimer's research & therapy\| PubMed ID: 23731836	2013
Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia. The Journal of experimental medicine\| PubMed ID: 23733784	2013
Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions. Brain research\| PubMed ID: 23774650	2013
γ-Secretase inhibitors and modulators. Biochimica et biophysica acta\| PubMed ID: 23791707	2013
Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain. PloS one\| PubMed ID: 23825679	2013
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. The Journal of clinical investigation\| PubMed ID: 23999428	2013
Anti-tau antibodies: hitting the target. Neuron\| PubMed ID: 24139027	2013
Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein. Acta neuropathologica communications\| PubMed ID: 24252149	2013
γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells. The Journal of biological chemistry\| PubMed ID: 24352661	2014
Open questions for Alzheimer's disease immunotherapy. Alzheimer's research & therapy\| PubMed ID: 24393284	2014
Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells. Frontiers in immunology\| PubMed ID: 24611064	2014
Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators. Biochemistry\| PubMed ID: 24620716	2014
Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24623762	2014
Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice. Acta neuropathologica\| PubMed ID: 24659240	2014
NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome. Frontiers in immunology\| PubMed ID: 24904593	2014
Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein. Journal of neurochemistry\| PubMed ID: 24984882	2014
Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25002524	2014
Brain Injection of α-Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25209277	2014