Haifan Lin

Yale Stem Cell Center and Department of Cell Biology, Yale University School of Medicine

Affiliated withYale University School of Medicine

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 34	2014

Other Publications

Article	Year
Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas. Oncogene\| PubMed ID: 12037681	2002
miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis. Developmental cell\| PubMed ID: 12062093	2002
The stem-cell niche theory: lessons from flies. Nature reviews. Genetics\| PubMed ID: 12459723	2002
Stem cells: to be and not to be. Nature\| PubMed ID: 14508468	2003
Screens for piwi suppressors in Drosophila identify dosage-dependent regulators of germline stem cell division. Genetics\| PubMed ID: 14704180	2003
Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development (Cambridge, England)\| PubMed ID: 14736746	2004
Nanos maintains germline stem cell self-renewal by preventing differentiation. Science (New York, N.Y.)\| PubMed ID: 14976263	2004
Germline stem cells in the Drosophila ovary descend from pole cells in the anterior region of the embryonic gonad. Development (Cambridge, England)\| PubMed ID: 15459101	2004
Regulatory relationship among piwi, pumilio, and bag-of-marbles in Drosophila germline stem cell self-renewal and differentiation. Current biology : CB\| PubMed ID: 15668175	2005
The division of Drosophila germline stem cells and their precursors requires a specific cyclin. Current biology : CB\| PubMed ID: 15723793	2005
A novel class of small RNAs in mouse spermatogenic cells. Genes & development\| PubMed ID: 16766680	2006
Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells. Journal of cell science\| PubMed ID: 16787948	2006
MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16938833	2006
The role of PIWI and the miRNA machinery in Drosophila germline determination. Current biology : CB\| PubMed ID: 16949822	2006
Sex-lethal is a target of Bruno-mediated translational repression in promoting the differentiation of stem cell progeny during Drosophila oogenesis. Developmental biology\| PubMed ID: 17067567	2007
Precancerous stem cells have the potential for both benign and malignant differentiation. PloS one\| PubMed ID: 17356702	2007
piRNAs in the germ line. Science (New York, N.Y.)\| PubMed ID: 17446387	2007
Drosophila PIWI associates with chromatin and interacts directly with HP1a. Genes & development\| PubMed ID: 17875665	2007
Dr. Haifan Lin. Interviewed by Han Lee and Rachel Rosenstein. The Yale journal of biology and medicine\| PubMed ID: 17940631	2006
An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster. Nature\| PubMed ID: 17952056	2007
Cell biology of stem cells: an enigma of asymmetry and self-renewal. The Journal of cell biology\| PubMed ID: 18227277	2008
Piecing together the mosaic of early mammalian development through microRNAs. The Journal of biological chemistry\| PubMed ID: 18272516	2008
MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. The Journal of biological chemistry\| PubMed ID: 19114715	2009
MicroRNAs: key regulators of stem cells. Nature reviews. Molecular cell biology\| PubMed ID: 19165214	2009
Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis. Current biology : CB\| PubMed ID: 19345100	2009
The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster. The Journal of cell biology\| PubMed ID: 19433453	2009
The biogenesis and function of PIWI proteins and piRNAs: progress and prospect. Annual review of cell and developmental biology\| PubMed ID: 19575643	2009
Stem cells in 2009. Cell stem cell\| PubMed ID: 19896440	2009
Dynamic transcriptomes during neural differentiation of human embryonic stem cells revealed by short, long, and paired-end sequencing. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20194744	2010
A Drosophila chromatin factor interacts with the Piwi-interacting RNA mechanism in niche cells to regulate germline stem cell self-renewal. Genetics\| PubMed ID: 20647505	2010
Identification of Piwil2-like (PL2L) proteins that promote tumorigenesis. PloS one\| PubMed ID: 20975993	2010
High-efficiency siRNA-based gene knockdown in human embryonic stem cells. RNA (New York, N.Y.)\| PubMed ID: 20978109	2010
The Yb body, a major site for Piwi-associated RNA biogenesis and a gateway for Piwi expression and transport to the nucleus in somatic cells. The Journal of biological chemistry\| PubMed ID: 21106531	2011
Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation. Nature genetics\| PubMed ID: 21186352	2011
MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline. Developmental cell\| PubMed ID: 21397847	2011
Genome-wide studies reveal that Lin28 enhances the translation of genes important for growth and survival of human embryonic stem cells. Stem cells (Dayton, Ohio)\| PubMed ID: 21425412	2011
PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition. Development (Cambridge, England)\| PubMed ID: 21447556	2011
Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse. Developmental biology\| PubMed ID: 21539824	2011
Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science (New York, N.Y.)\| PubMed ID: 21566194	2011
Small noncoding RNAs in the germline. Cold Spring Harbor perspectives in biology\| PubMed ID: 21669983	2011
Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organisms. Annual review of genetics\| PubMed ID: 21942366	2011
A high-resolution whole-genome map of key chromatin modifications in the adult Drosophila melanogaster. PLoS genetics\| PubMed ID: 22194694	2011
Pumilio 1 suppresses multiple activators of p53 to safeguard spermatogenesis. Current biology : CB\| PubMed ID: 22342750	2012
Essential roles of the chromatin remodeling factor BRG1 in spermatogenesis in mice. Biology of reproduction\| PubMed ID: 22495890	2012
High-efficiency transfection and siRNA-mediated gene knockdown in human pluripotent stem cells. Current protocols in stem cell biology\| PubMed ID: 22605647	2012
piRNA biogenesis during adult spermatogenesis in mice is independent of the ping-pong mechanism. Cell research\| PubMed ID: 22907665	2012
The miRNA Regulation of Stem Cells. Wiley interdisciplinary reviews. Membrane transport and signaling\| PubMed ID: 23024929	2012
Capturing the cloud: UAP56 in nuage assembly and function. Cell\| PubMed ID: 23141532	2012
Function of Piwi, a nuclear Piwi/Argonaute protein, is independent of its slicer activity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23297219	2013
A major epigenetic programming mechanism guided by piRNAs. Developmental cell\| PubMed ID: 23434410	2013
Beyond transposons: the epigenetic and somatic functions of the Piwi-piRNA mechanism. Current opinion in cell biology\| PubMed ID: 23465540	2013
Repressing the repressor: a lincRNA as a MicroRNA sponge in embryonic stem cell self-renewal. Developmental cell\| PubMed ID: 23597480	2013
Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline. The EMBO journal\| PubMed ID: 23714778	2013
The microRNA regulation of stem cells. Wiley interdisciplinary reviews. Developmental biology\| PubMed ID: 23801669	2012
Piwi genes are dispensable for normal hematopoiesis in mice. PloS one\| PubMed ID: 24058407	2013
Chromatin immunoprecipitation assay of Piwi in Drosophila. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 24178552	2014
PIWI proteins are essential for early Drosophila embryogenesis. Developmental biology\| PubMed ID: 24184635	2014
PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24367095	2014
PIWI proteins and PIWI-interacting RNAs in the soma. Nature\| PubMed ID: 24429634	2014
Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary. PloS one\| PubMed ID: 24658126	2014
Noncoding RNAs in the regulation of DNA replication. Trends in biochemical sciences\| PubMed ID: 25027733	2014