John W.R. Schwabe

Department of Biochemistry, University of Leicester

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 70	2014

Other Publications

Article	Year
The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12. The Journal of biological chemistry\| PubMed ID: 11782480	2002
A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease. Nature structural biology\| PubMed ID: 12536206	2003
A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling. Genes & development\| PubMed ID: 12897056	2003
Molecular determinants of the balance between co-repressor and co-activator recruitment to the retinoic acid receptor. The Journal of biological chemistry\| PubMed ID: 12917445	2003
Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma. Endocrinology\| PubMed ID: 14657011	2004
Nuclear receptors: the evolution of diversity. Science's STKE : signal transduction knowledge environment\| PubMed ID: 14747695	2004
Mechanism of the nuclear receptor molecular switch. Trends in biochemical sciences\| PubMed ID: 15276186	2004
Identification of a novel co-regulator interaction surface on the ligand binding domain of Nurr1 using NMR footprinting. The Journal of biological chemistry\| PubMed ID: 15456745	2004
Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15837933	2005
Structural basis for the activation of PPARgamma by oxidized fatty acids. Nature structural & molecular biology\| PubMed ID: 19172745	2008
Comparison of the molecular consequences of different mutations at residue 754 and 690 of the androgen receptor (AR) and androgen insensitivity syndrome (AIS) phenotype. Clinical endocrinology\| PubMed ID: 19178528	2009
Negative regulation by nuclear receptors: a plethora of mechanisms. Trends in endocrinology and metabolism: TEM\| PubMed ID: 21196123	2011
Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery. Nature structural & molecular biology\| PubMed ID: 21240272	2011
The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. Genes & development\| PubMed ID: 21685362	2011
Nuclear hormone receptor co-repressors: structure and function. Molecular and cellular endocrinology\| PubMed ID: 21925568	2012
FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22109552	2011
A mutation in the thyroid hormone receptor alpha gene. The New England journal of medicine\| PubMed ID: 22168587	2012
Structure of HDAC3 bound to co-repressor and inositol tetraphosphate. Nature\| PubMed ID: 22230954	2012
A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death. Molecular cell\| PubMed ID: 22683266	2012
Class I HDACs share a common mechanism of regulation by inositol phosphates. Molecular cell\| PubMed ID: 23791785	2013
Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6). Molecular biology of the cell\| PubMed ID: 24006493	2013
An evolving understanding of nuclear receptor coregulator proteins. Journal of molecular endocrinology\| PubMed ID: 24203923	2013
The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain. PloS one\| PubMed ID: 24595451	2014
Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24958871	2014