Zena Werb

Department of Anatomy, University of California

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2014

Other Publications

Article	Year
Shedding light on sheddases: role in growth and development. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 11782944	2002
Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2. Journal of cell science\| PubMed ID: 11865039	2002
Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency. Nature immunology\| PubMed ID: 11887181	2002
Developmental biology: vasculogenesis is a wreck without RECK. Current biology : CB\| PubMed ID: 11909548	2002
New functions for the matrix metalloproteinases in cancer progression. Nature reviews. Cancer\| PubMed ID: 11990853	2002
Metalloproteases and adipogenesis: a weighty subject. The American journal of pathology\| PubMed ID: 12000705	2002
Stromal effects on mammary gland development and breast cancer. Science (New York, N.Y.)\| PubMed ID: 12004111	2002
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell\| PubMed ID: 12062105	2002
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nature medicine\| PubMed ID: 12091880	2002
Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. The Journal of cell biology\| PubMed ID: 12119354	2002
The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. The Journal of cell biology\| PubMed ID: 12119356	2002
Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12196576	2002
beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer cell\| PubMed ID: 12242153	2002
Matrix metalloproteinase-9 contributes to choroidal neovascularization. The American journal of pathology\| PubMed ID: 12368198	2002
Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis. The American journal of pathology\| PubMed ID: 12368215	2002
Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. The Journal of biological chemistry\| PubMed ID: 12368295	2002
New functional roles for non-collagenous domains of basement membrane collagens. Journal of cell science\| PubMed ID: 12376553	2002
Inflammation and cancer. Nature\| PubMed ID: 12490959	2002
Tube or not tube: remodeling epithelial tissues by branching morphogenesis. Developmental cell\| PubMed ID: 12530959	2003
Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases. Current opinion in hematology\| PubMed ID: 12579040	2003
New insights into saccular development and vascular formation in lung allografts under the renal capsule. Mechanisms of development\| PubMed ID: 12591600	2003
Epithelial morphogenesis: Netrin comes to a sticky and terminal end. Current biology : CB\| PubMed ID: 12814570	2003
How proteases regulate bone morphogenesis. Annals of the New York Academy of Sciences\| PubMed ID: 12814943	2003
Role of collagen type II and perlecan in skeletal development. Annals of the New York Academy of Sciences\| PubMed ID: 12814946	2003
Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer cell\| PubMed ID: 12842087	2003
Altered fracture repair in the absence of MMP9. Development (Cambridge, England)\| PubMed ID: 12874132	2003
A functional overlap of plasminogen and MMPs regulates vascularization during placental development. Development (Cambridge, England)\| PubMed ID: 12900459	2003
Macrophages contribute to the maintenance of stable regenerating neurites following peripheral nerve injury. Journal of neuroscience research\| PubMed ID: 12929132	2003
Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing. Journal of neurosurgery\| PubMed ID: 12956462	2003
Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. The EMBO journal\| PubMed ID: 12970191	2003
Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. The Journal of cell biology\| PubMed ID: 12975354	2003
Role of c-kit/Kit ligand signaling in regulating vasculogenesis. Thrombosis and haemostasis\| PubMed ID: 14515175	2003
Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. Journal of neuroscience research\| PubMed ID: 14515352	2003
MMP-2 and MMP-9 synergize in promoting choroidal neovascularization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 14563686	2003
Ets2-dependent stromal regulation of mouse mammary tumors. Molecular and cellular biology\| PubMed ID: 14612405	2003
A bit of give and take: the relationship between the extracellular matrix and the developing chondrocyte. Mechanisms of development\| PubMed ID: 14623441	2003
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14668450	2003
Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast cancer research : BCR\| PubMed ID: 14680479	2004
Zena Werb [interview by Fiona M Watt]. Journal of cell science\| PubMed ID: 14963020	2004
Stromal matrix metalloproteinase-9 regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment. Cancer research\| PubMed ID: 14996727	2004
Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15059974	2004
Matrix remodeling during endochondral ossification. Trends in cell biology\| PubMed ID: 15102440	2004
Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues. Development (Cambridge, England)\| PubMed ID: 15163627	2004
Regulation of matrix biology by matrix metalloproteinases. Current opinion in cell biology\| PubMed ID: 15363807	2004
Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. The Journal of biological chemistry\| PubMed ID: 15456762	2004
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development (Cambridge, England)\| PubMed ID: 15539485	2004
Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15550552	2005
Tissue inhibitor of metalloproteinase 1 regulates resistance to infection. Infection and immunity\| PubMed ID: 15618213	2005
Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo. Diabetes\| PubMed ID: 15734845	2005
Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation. Molecular biology of the cell\| PubMed ID: 15800063	2005
Synergy between a plasminogen cascade and MMP-9 in autoimmune disease. The Journal of clinical investigation\| PubMed ID: 15841177	2005
Coevolution of cancer and stromal cellular responses. Cancer cell\| PubMed ID: 15950897	2005
Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15994223	2005
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature\| PubMed ID: 16001073	2005
A role for niches in hematopoietic cell development. Hematology (Amsterdam, Netherlands)\| PubMed ID: 16019473	2005
Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development (Cambridge, England)\| PubMed ID: 16079154	2005
PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nature cell biology\| PubMed ID: 16113679	2005
Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization. The Journal of experimental medicine\| PubMed ID: 16157686	2005
Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. The Journal of biological chemistry\| PubMed ID: 16186104	2005
Mfge8 is critical for mammary gland remodeling during involution. Molecular biology of the cell\| PubMed ID: 16195353	2005
Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Development (Cambridge, England)\| PubMed ID: 16236767	2005
Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer. Neoplasia (New York, N.Y.)\| PubMed ID: 16331886	2005
Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice. The Journal of investigative dermatology\| PubMed ID: 16374453	2006
HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. BMC biochemistry\| PubMed ID: 16417632	2006
Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. PLoS medicine\| PubMed ID: 16509766	2006
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nature medicine\| PubMed ID: 16648859	2006
Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. The EMBO journal\| PubMed ID: 16763560	2006
Hormonal and local control of mammary branching morphogenesis. Differentiation; research in biological diversity\| PubMed ID: 16916375	2006
Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17005848	2006
Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 17039550	2006
Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17082650	2006
Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2. Molecular and cellular biology\| PubMed ID: 17116694	2007
Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 17119035	2006
Comparative mechanisms of branching morphogenesis in diverse systems. Journal of mammary gland biology and neoplasia\| PubMed ID: 17120154	2006
GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell\| PubMed ID: 17129787	2006
Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A. Endocrine-related cancer\| PubMed ID: 17158762	2006
Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. Physiological reviews\| PubMed ID: 17237343	2007
Roles of the innate immune system in mammary gland remodeling during involution. Journal of mammary gland biology and neoplasia\| PubMed ID: 17286210	2007
Matrix metalloproteinases and the regulation of tissue remodelling. Nature reviews. Molecular cell biology\| PubMed ID: 17318226	2007
Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Molecular biology of the cell\| PubMed ID: 17332496	2007
The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10. The Journal of biological chemistry\| PubMed ID: 17389606	2007
Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 17392479	2007
Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 17440987	2007
The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium. Developmental biology\| PubMed ID: 17448457	2007
G'rab'bing the microenvironment for invasion. Developmental cell\| PubMed ID: 17925222	2007
Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. PloS one\| PubMed ID: 17987127	2007
Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma. Cancer research\| PubMed ID: 18056472	2007
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression. Cancer research\| PubMed ID: 18199546	2008
GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer cell\| PubMed ID: 18242514	2008
A model of intussusceptive angiogenesis. Novartis Foundation symposium\| PubMed ID: 18300412	2007
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer cell\| PubMed ID: 18328425	2008
GATA-3 and the regulation of the mammary luminal cell fate. Current opinion in cell biology\| PubMed ID: 18358709	2008
The apical ectodermal ridge is a timer for generating distal limb progenitors. Development (Cambridge, England)\| PubMed ID: 18359901	2008
Location, location, location: the cancer stem cell niche. Cell stem cell\| PubMed ID: 18371402	2007
The plasminogen fibrinolytic pathway is required for hematopoietic regeneration. Cell stem cell\| PubMed ID: 18371407	2007
Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer. Cell stem cell\| PubMed ID: 18371425	2008
Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis. Current biology : CB\| PubMed ID: 18394894	2008
Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. Developmental cell\| PubMed ID: 18410732	2008
Lifeact: a versatile marker to visualize F-actin. Nature methods\| PubMed ID: 18536722	2008
Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis. Developmental biology\| PubMed ID: 18585375	2008
Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression. PloS one\| PubMed ID: 18698413	2008
Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Disease models & mechanisms\| PubMed ID: 19048079	2008
Patterning mechanisms of branched organs. Science (New York, N.Y.)\| PubMed ID: 19056977	2008
Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19074020	2008
Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution. The Journal of biological chemistry\| PubMed ID: 19297327	2009
MMP9 and SCF protect from apoptosis in acute kidney injury. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19329763	2009
Netting neutrophils in autoimmune small-vessel vasculitis. Nature medicine\| PubMed ID: 19448636	2009
GATA3 in development and cancer differentiation: cells GATA have it! Journal of cellular physiology\| PubMed ID: 19798694	2010
Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis. Developmental biology\| PubMed ID: 19850030	2010
Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. The Journal of clinical investigation\| PubMed ID: 19884654	2009
MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma. Carcinogenesis\| PubMed ID: 19892798	2010
Intravital imaging of stromal cell dynamics in tumors. Current opinion in genetics & development\| PubMed ID: 19942428	2010
Mapping mammary gland architecture using multi-scale in situ analysis. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20023794	2009
Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration. Blood\| PubMed ID: 20110420	2010
Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation. Disease models & mechanisms\| PubMed ID: 20142327	2010
Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression. Cancer research\| PubMed ID: 20215503	2010
Stromal regulation of vessel stability by MMP14 and TGFbeta. Disease models & mechanisms\| PubMed ID: 20223936	2010
Matrix metalloproteinases: regulators of the tumor microenvironment. Cell\| PubMed ID: 20371345	2010
Matrix metalloproteinases and neurotrauma: evolving roles in injury and reparative processes. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry\| PubMed ID: 20400713	2010
Tumors as organs: complex tissues that interface with the entire organism. Developmental cell\| PubMed ID: 20627072	2010
The extracellular matrix and disease: An interview with Zena Werb. Interviewed by Kristin H. Kain. Disease models & mechanisms\| PubMed ID: 20699476	2010
The joy of a career in cell biology. Molecular biology of the cell\| PubMed ID: 21079003	2010
Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21098272	2010
Mammary gland reprogramming: metalloproteinases couple form with function. Cold Spring Harbor perspectives in biology\| PubMed ID: 21106646	2011
Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2. Disease models & mechanisms\| PubMed ID: 21135056	2011
Preparation of mice for long-term intravital imaging of the mammary gland. Cold Spring Harbor protocols\| PubMed ID: 21285262	2011
Monitoring of vital signs for long-term survival of mice under anesthesia. Cold Spring Harbor protocols\| PubMed ID: 21285263	2011
Dynamic, long-term in vivo imaging of tumor-stroma interactions in mouse models of breast cancer using spinning-disk confocal microscopy. Cold Spring Harbor protocols\| PubMed ID: 21285277	2011
Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. Genes & development\| PubMed ID: 21317240	2011
A whole-organism screen identifies new regulators of fat storage. Nature chemical biology\| PubMed ID: 21390037	2011
Measuring matrix metalloproteinase activity in macrophages and polymorphonuclear leukocytes. Current protocols in immunology / edited by John E. Coligan ... [et al.]\| PubMed ID: 21462166	2011
Dual protective mechanisms of matrix metalloproteinases 2 and 9 in immune defense against Streptococcus pneumoniae. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21508260	2011
Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid. The Journal of biological chemistry\| PubMed ID: 21880713	2011
Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harbor perspectives in biology\| PubMed ID: 21917992	2011
Matrix metalloproteinase-9 and stromal cell-derived factor-1 act synergistically to support migration of blood-borne monocytes into the injured spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22049432	2011
Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma. The Journal of clinical investigation\| PubMed ID: 22293178	2012
Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22308451	2012
Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium. Journal of cell science\| PubMed ID: 22344263	2012
The extracellular matrix: a dynamic niche in cancer progression. The Journal of cell biology\| PubMed ID: 22351925	2012
Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer cell\| PubMed ID: 22439936	2012
Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer cell\| PubMed ID: 22516258	2012
Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. The Journal of clinical investigation\| PubMed ID: 22684106	2012
The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. Cancer discovery\| PubMed ID: 22728437	2012
ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22923691	2012
MMP9 regulates the cellular response to inflammation after skeletal injury. Bone\| PubMed ID: 23010105	2013
MicroRNAs play a big role in regulating ovarian cancer-associated fibroblasts and the tumor microenvironment. Cancer discovery\| PubMed ID: 23230184	2012
Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell reports\| PubMed ID: 23352663	2013
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nature cell biology\| PubMed ID: 23354167	2013
Molecular determinants of lung development. Annals of the American Thoracic Society\| PubMed ID: 23607856	2013
Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23776237	2013
Protective effects of matrix metalloproteinase-12 following corneal injury. Journal of cell science\| PubMed ID: 23813962	2013
A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell stem cell\| PubMed ID: 23871604	2013
Roadblocks to translational advances on metastasis research. Nature medicine\| PubMed ID: 24013756	2013
Cancer. Circulating tumor cells. Science (New York, N.Y.)\| PubMed ID: 24031008	2013
microRNA-mediated regulation of the tumor microenvironment. Cell cycle (Georgetown, Tex.)\| PubMed ID: 24036551	2013
In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. PLoS biology\| PubMed ID: 24260022	2013
Collective invasion in breast cancer requires a conserved basal epithelial program. Cell\| PubMed ID: 24332913	2013
Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs. PloS one\| PubMed ID: 24788791	2014
A Multilevel Model of Postmenopausal Breast Cancer Incidence. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 25017248	2014