Paolo Ghia

Division of Molecular Oncology, IRCCS, San Raffaele Scientific Institute

Affiliated withIRCCS, San Raffaele Scientific Institute Università Vita-Salute San Raffaele IRCCS Istituto Scientifico San Raffaele and Università Vita-Salute San Raffaele

Research Area

Biography

Paolo Ghia has not added Biography.
If you are Paolo Ghia and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 3	2014
Publication title Cited by 14	2018

Other Publications

Article	Year
Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22. European journal of immunology\| PubMed ID: 11981828	2002
Chronic B cell malignancies and bone marrow microenvironment. Seminars in cancer biology\| PubMed ID: 12027587	2002
CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells. British journal of haematology\| PubMed ID: 12406091	2002
CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes. Blood\| PubMed ID: 12406905	2003
The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression. Blood\| PubMed ID: 12406914	2003
Chronic lymphocytic leukaemia: a model for investigating potential new targets for the therapy of indolent lymphomas. Best practice & research. Clinical haematology\| PubMed ID: 12468406	2002
Expansion of tumor-specific CD8+ T cell clones in patients with relapsed myeloma after donor lymphocyte infusion. Cancer research\| PubMed ID: 12750280	2003
The characterization of chemokine production and chemokine receptor expression reveals possible functional cross-talks in AML blasts with monocytic differentiation. Experimental hematology\| PubMed ID: 12829025	2003
IL-12 regulates an endothelial cell-lymphocyte network: effect on metalloproteinase-9 production. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14500672	2003
Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly. Blood\| PubMed ID: 14630808	2004
Leukemia-derived immature dendritic cells differentiate into functionally competent mature dendritic cells that efficiently stimulate T cell responses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15295005	2004
The nature and origin of the B-chronic lymphocytic leukemia cell: a tentative model. Hematology/oncology clinics of North America\| PubMed ID: 15325702	2004
Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene. Blood\| PubMed ID: 15466924	2005
Vdelta1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and up-regulated by trans-retinoic acid. Cancer research\| PubMed ID: 15604289	2004
HS1 protein is differentially expressed in chronic lymphocytic leukemia patient subsets with good or poor prognoses. The Journal of clinical investigation\| PubMed ID: 15931393	2005
Diagnostic criteria for monoclonal B-cell lymphocytosis. British journal of haematology\| PubMed ID: 16042682	2005
Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemia. Cancer research\| PubMed ID: 16267031	2005
The origin of B-cell chronic lymphocytic leukemia. Seminars in oncology\| PubMed ID: 16616061	2006
IGHV gene insertions and deletions in chronic lymphocytic leukemia: "CLL-biased" deletions in a subset of cases with stereotyped receptors. European journal of immunology\| PubMed ID: 16783849	2006
Evaluation of ZAP-70 expression by flow cytometry in chronic lymphocytic leukemia: A multicentric international harmonization process. Cytometry. Part B, Clinical cytometry\| PubMed ID: 16906588	2006
Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations. Blood\| PubMed ID: 16985177	2007
Chronic lymphocytic leukemia. Critical reviews in oncology/hematology\| PubMed ID: 17544290	2007
The normal counterpart to the chronic lymphocytic leukemia B cell. Best practice & research. Clinical haematology\| PubMed ID: 17707828	2007
A woman and her canary: a tale of chlamydiae and lymphomas. Journal of the National Cancer Institute\| PubMed ID: 17848672	2007
Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood\| PubMed ID: 17959859	2008
Overview of monoclonal B-cell lymphocytosis. British journal of haematology\| PubMed ID: 18021084	2007
Age-dependent accumulation of monoclonal CD4+CD8+ double positive T lymphocytes in the peripheral blood of the elderly. British journal of haematology\| PubMed ID: 18021092	2007
From normal to clonal B cells: Chronic lymphocytic leukemia (CLL) at the crossroad between neoplasia and autoimmunity. Autoimmunity reviews\| PubMed ID: 18035322	2007
Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy. Blood\| PubMed ID: 18292287	2008
Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease? Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 18662968	2008
Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia. Blood\| PubMed ID: 18948572	2009
The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring. Blood\| PubMed ID: 19029437	2009
Expression and function of toll like receptors in chronic lymphocytic leukaemia cells. British journal of haematology\| PubMed ID: 19036098	2009
B-cell clones as early markers for chronic lymphocytic leukemia. The New England journal of medicine\| PubMed ID: 19213679	2009
Introduction to Chronic Lymphocytic Leukemia Young Investigator's Meeting. Leukemia & lymphoma\| PubMed ID: 19347731	2009
Monoclonal B lymphocytosis in the general population. Leukemia & lymphoma\| PubMed ID: 19347732	2009
The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood\| PubMed ID: 19636060	2009
Evidence of serum immunoglobulin abnormalities up to 9.8 years before diagnosis of chronic lymphocytic leukemia: a prospective study. Blood\| PubMed ID: 19828698	2009
A novel Rag2-/-gammac-/--xenograft model of human CLL. Blood\| PubMed ID: 20018917	2010
MicroRNA and proliferation control in chronic lymphocytic leukemia: functional relationship between miR-221/222 cluster and p27. Blood\| PubMed ID: 20203269	2010
HS1 has a central role in the trafficking and homing of leukemic B cells. Blood\| PubMed ID: 20530793	2010
ZAP-70 expression is associated with increased risk of autoimmune cytopenias in CLL patients. American journal of hematology\| PubMed ID: 20575031	2010
How the microenvironment shapes chronic lymphocytic leukemia: the cytoskeleton connection. Leukemia & lymphoma\| PubMed ID: 20687794	2010
CLL-like monoclonal B-cell lymphocytosis: are we all bound to have it? Seminars in cancer biology\| PubMed ID: 20816789	2010
Different biology and clinical outcome according to the absolute numbers of clonal B-cells in monoclonal B-cell lymphocytosis (MBL). Cytometry. Part B, Clinical cytometry\| PubMed ID: 20839333	2010
Commentary: Comparison of current flow cytometry methods for monoclonal B cell lymphocytosis detection. Cytometry. Part B, Clinical cytometry\| PubMed ID: 20839336	2010
Monoclonal B cell lymphocytosis in hepatitis C virus infected individuals. Cytometry. Part B, Clinical cytometry\| PubMed ID: 20839339	2010
Inherited genetic susceptibility to monoclonal B-cell lymphocytosis. Blood\| PubMed ID: 20855867	2010
Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21189302	2011
In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor. Blood\| PubMed ID: 21406718	2011
Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models. Blood\| PubMed ID: 21652674	2011
Toll-like receptor signaling pathway in chronic lymphocytic leukemia: distinct gene expression profiles of potential pathogenic significance in specific subsets of patients. Haematologica\| PubMed ID: 21750087	2011
Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases. Blood\| PubMed ID: 21791422	2011
Another piece of the puzzle: is there a "nodal" monoclonal B-cell lymphocytosis? Haematologica\| PubMed ID: 21810972	2011
General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL. Blood\| PubMed ID: 21876118	2011
Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies. Blood\| PubMed ID: 22415752	2012
Monoclonal B-cell lymphocytosis: right track or red herring? Blood\| PubMed ID: 22422819	2012
KIBRA gene methylation is associated with unfavorable biological prognostic parameters in chronic lymphocytic leukemia. Epigenetics : official journal of the DNA Methylation Society\| PubMed ID: 22430796	2012
Distinct innate immunity pathways to activation and tolerance in subgroups of chronic lymphocytic leukemia with distinct immunoglobulin receptors. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 22437326	2012
KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function. Blood\| PubMed ID: 22452978	2012
Changes in the apoptotic gene expression profile in CLL patients treated with rituximab combined with cladribine and cyclophosphamide-preliminary results. Leukemia research\| PubMed ID: 22608309	2012
Bone marrow histopathology in the diagnostic evaluation of splenic marginal-zone and splenic diffuse red pulp small B-cell lymphoma: a reliable substitute for spleen histopathology? The American journal of surgical pathology\| PubMed ID: 23073320	2012
In vitro sensitivity of CLL cells to fludarabine may be modulated by the stimulation of Toll-like receptors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23224401	2013
A look into the future: can minimal residual disease guide therapy and predict prognosis in chronic lymphocytic leukemia? Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program\| PubMed ID: 23233566	2012
Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia. Blood\| PubMed ID: 23325840	2013
Targeting B-cell anergy in chronic lymphocytic leukemia. Blood\| PubMed ID: 23460614	2013
MBL versus CLL: how important is the distinction? Hematology/oncology clinics of North America\| PubMed ID: 23561472	2013
Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL. Blood\| PubMed ID: 23596047	2013
Differential microRNA profiles and their functional implications in different immunogenetic subsets of chronic lymphocytic leukemia. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 23615967	2013
Loss of function of Ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23630276	2013
Antigen selection in B-cell lymphomas--tracing the evidence. Seminars in cancer biology\| PubMed ID: 23932942	2013
Monoclonal B cell lymphocytosis and "in situ" lymphoma. Seminars in cancer biology\| PubMed ID: 23999128	2014
Reprogramming cell death: BCL2 family inhibition in hematological malignancies. Immunology letters\| PubMed ID: 24095849	2013
IgG-switched CLL has a distinct immunogenetic signature from the common MD variant: ontogenetic implications. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 24240110	2014
Monoclonal B-cell lymphocytosis in healthy blood donors: an unexpectedly common finding. Blood\| PubMed ID: 24345750	2014
The microenvironment in lymphomas--dissecting the complex crosstalk between tumor cells and 'by-stander' cells. Seminars in cancer biology\| PubMed ID: 24365642	2014
Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. The New England journal of medicine\| PubMed ID: 24450857	2014
Clonal B-cell lymphocytosis: a new member? Blood\| PubMed ID: 24558188	2014
Heterogeneous functional effects of concomitant B cell receptor and TLR stimulation in chronic lymphocytic leukemia with mutated versus unmutated Ig genes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24719462	2014
The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors. British journal of haematology\| PubMed ID: 24725250	2014
SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders. Haematologica\| PubMed ID: 24859880	2014
Management of chronic lymphocytic leukemia. Haematologica\| PubMed ID: 24881042	2014
Bendamustine and subcutaneous alemtuzumab combination is an effective treatment in relapsed/refractory chronic lymphocytic leukemia patients. Haematologica\| PubMed ID: 24972768	2014
Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy. Blood\| PubMed ID: 25006127	2014
Immunogenetic studies of chronic lymphocytic leukemia: revelations and speculations about ontogeny and clinical evolution. Cancer research\| PubMed ID: 25074616	2014
MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis. Haematologica\| PubMed ID: 25082786	2014
Ibrutinib: better combined with other drugs? The Lancet. Oncology\| PubMed ID: 25150799	2014
Toll-like receptor stimulation in splenic marginal zone lymphoma can modulate cell signaling, activation and proliferation. Haematologica\| PubMed ID: 26294727	2015
Targeting Hedgehog in haematological malignancies. The Lancet. Haematology\| PubMed ID: 26688482	2015
Innovation in the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go? Haematologica\| PubMed ID: 26928246	2016
A new life for rituximab? The Lancet. Haematology\| PubMed ID: 26947197	2016
Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study. The Lancet. Haematology\| PubMed ID: 27030157	2014
Similar epidemiological trends of pre-neoplastic precursors and their respective lymphoid malignancies in Taiwan. Annals of hematology\| PubMed ID: 27431581	2016
Ibrutinib holds promise for patients with 17p deletion CLL. The Lancet. Oncology\| PubMed ID: 27637986	2016
Ibrutinib in the real world patient: many lights and some shades. Haematologica\| PubMed ID: 27903711	2016
Distinct molecular genetics of chronic lymphocytic leukemia in Taiwan: clinical and pathogenetic implications. Haematologica\| PubMed ID: 28255015	2017
Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification. Haematologica\| PubMed ID: 28566340	2017
Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations. Haematologica\| PubMed ID: 29449433	2018
ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia-update on methodological approaches and results interpretation. Leukemia\| PubMed ID: 29467486	2018
Minimal residual disease analysis in chronic lymphocytic leukemia: a way for achieving more personalized treatments. Leukemia\| PubMed ID: 29700386	2018
Monoclonal B-cell lymphocytosis: Does the elderly patient need a specialistic approach? European journal of internal medicine\| PubMed ID: 30268574	2018
TP53 aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics. Haematologica\| PubMed ID: 30442727	2018