Michael V. Sofroniew

Department of Neurobiology, University of California Los Angeles

Affiliated withUniversity of California Los Angeles

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 24	2014

Other Publications

Article	Year
Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro. PloS one\| PubMed ID: 20224768	2010
The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12684469	2003
The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells. The European journal of neuroscience\| PubMed ID: 12859339	2003
Reactive astrocytes protect tissue and preserve function after spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14999065	2004
GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nature neuroscience\| PubMed ID: 15494728	2004
Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. The Journal of cell biology\| PubMed ID: 16061694	2005
Reactive astrocytes in neural repair and protection. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry\| PubMed ID: 16151042	2005
Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytes. Glia\| PubMed ID: 16267834	2006
Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17088541	2006
Paradoxical influence of hippocampal neurogenesis on working memory. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17360577	2007
Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione. Gastroenterology\| PubMed ID: 17408650	2007
Starring roles for astroglia in barrier pathologies of gut and brain. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 17607301	2007
Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury. Nature medicine\| PubMed ID: 18157143	2008
Glia get excited. Nature neuroscience\| PubMed ID: 18368040	2008
Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration. Experimental neurology\| PubMed ID: 18410928	2008
Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18579739	2008
STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18614693	2008
Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19211894	2009
Biocompatibility of amphiphilic diblock copolypeptide hydrogels in the central nervous system. Biomaterials\| PubMed ID: 19251318	2009
Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19759299	2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input. Nature neuroscience\| PubMed ID: 19767747	2009
Molecular dissection of reactive astrogliosis and glial scar formation. Trends in neurosciences\| PubMed ID: 19782411	2009
PTEN dosage is essential for neurofibroma development and malignant transformation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19846776	2009
Astrocytes: biology and pathology. Acta neuropathologica\| PubMed ID: 20012068	2010
A genetically targeted optical sensor to monitor calcium signals in astrocyte processes. Nature neuroscience\| PubMed ID: 20495558	2010
Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination. Brain : a journal of neurology\| PubMed ID: 20858739	2010
Reactive astrocytes as therapeutic targets for CNS disorders. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 20880511	2010
Adenomatous polyposis coli is essential for both neuronal differentiation and maintenance of adult neural stem cells in subventricular zone and hippocampus. Stem cells (Dayton, Ohio)\| PubMed ID: 21089118	2010
Neuromyelitis optica: circulating autoantibodies provoke astrocyte-mediated neural dysfunction. Neurology\| PubMed ID: 21368284	2011
Loss of adenomatous polyposis coli in Bergmann glia disrupts their unique architecture and leads to cell nonautonomous neurodegeneration of cerebellar Purkinje neurons. Glia\| PubMed ID: 21381115	2011
Neuroprotection mediated through estrogen receptor-alpha in astrocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21555578	2011
Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21632951	2011
Transgenic techniques for cell ablation or molecular deletion to investigate functions of astrocytes and other GFAP-expressing cell types. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22144330	2012
Neurological diseases as primary gliopathies: a reassessment of neurocentrism. ASN neuro\| PubMed ID: 22339481	2012
Juvenile neurogenesis makes essential contributions to adult brain structure and plays a sex-dependent role in fear memories. Frontiers in behavioral neuroscience\| PubMed ID: 22347173	2012
Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. The Journal of clinical investigation\| PubMed ID: 22653056	2012
STAT3-mediated astrogliosis protects myelin development in neonatal brain injury. Annals of neurology\| PubMed ID: 22941903	2012
Sustained local delivery of bioactive nerve growth factor in the central nervous system via tunable diblock copolypeptide hydrogel depots. Biomaterials\| PubMed ID: 22985994	2012
Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23077035	2012
Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses. The Journal of general physiology\| PubMed ID: 23589582	2013
Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23804112	2013
Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23904622	2013
Multiple roles for astrocytes as effectors of cytokines and inflammatory mediators. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry\| PubMed ID: 24106265	2014
Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system. Biomaterials\| PubMed ID: 24314556	2014
Heterogeneity of reactive astrocytes. Neuroscience letters\| PubMed ID: 24361547	2014
Reactive gliosis and the multicellular response to CNS damage and disease. Neuron\| PubMed ID: 24462092	2014
Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice. Nature neuroscience\| PubMed ID: 24686787	2014
Traumatic brain injury reveals novel cell lineage relationships within the subventricular zone. Stem cell research\| PubMed ID: 24835668	2014
Astrocytes and Huntington's disease. ACS chemical neuroscience\| PubMed ID: 24842291	2014
Memantine enhances recovery from stroke. Stroke; a journal of cerebral circulation\| PubMed ID: 24938836	2014
Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis. Journal of neuroimmunology\| PubMed ID: 25005117	2014
Early activation of STAT3 regulates reactive astrogliosis induced by diverse forms of neurotoxicity. PloS one\| PubMed ID: 25025494	2014
Astrogliosis. Cold Spring Harbor perspectives in biology\| PubMed ID: 25380660	2014