Ruth S. Slack

Department of Cellular and Molecular Medicine, University of Ottawa

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 2	2015
Publication title Cited by 2	2017

Other Publications

Article	Year
The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate. The Journal of cell biology\| PubMed ID: 17591923	2007
Cell cycle regulator E2F4 is essential for the development of the ventral telencephalon. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17537963	2007
Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease. Neuron\| PubMed ID: 17610816	2007
Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 11823715	2002
The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 11896143	2002
Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage. The Journal of biological chemistry\| PubMed ID: 12091388	2002
Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development. The EMBO journal\| PubMed ID: 12093735	2002
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. The Journal of cell biology\| PubMed ID: 12147675	2002
Caspase 3 activity is required for skeletal muscle differentiation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12177420	2002
Calpains mediate p53 activation and neuronal death evoked by DNA damage. The Journal of biological chemistry\| PubMed ID: 12721303	2003
Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12764095	2003
Growth factors: can they promote neurogenesis? Trends in neurosciences\| PubMed ID: 12798593	2003
Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage. The Journal of biological chemistry\| PubMed ID: 12857758	2003
Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14595022	2003
Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15044535	2004
Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene\| PubMed ID: 15077142	2004
The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1. The Journal of biological chemistry\| PubMed ID: 15105421	2004
Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. Cancer cell\| PubMed ID: 15193257	2004
p107 regulates neural precursor cells in the mammalian brain. The Journal of cell biology\| PubMed ID: 15353549	2004
Emerging role for ERK as a key regulator of neuronal apoptosis. Science's STKE : signal transduction knowledge environment\| PubMed ID: 15383672	2004
p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15525786	2004
c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation. The Journal of biological chemistry\| PubMed ID: 15528206	2005
The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis. The Journal of clinical investigation\| PubMed ID: 15668733	2005
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15703386	2005
Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16166266	2005
Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16192386	2005
A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration. The EMBO journal\| PubMed ID: 16308563	2005
Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase. Journal of neurochemistry\| PubMed ID: 16336220	2006
Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16407541	2006
Novel functions for cell cycle genes in nervous system development. Cell cycle (Georgetown, Tex.)\| PubMed ID: 16861920	2006
Urine concentrating defect in prostaglandin EP1-deficient mice. American journal of physiology. Renal physiology\| PubMed ID: 16885154	2007
Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. The EMBO journal\| PubMed ID: 16917506	2006
The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16928871	2006
Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions. Molecular and cellular biology\| PubMed ID: 17452454	2007
Mitochondrial dynamics in the regulation of neuronal cell death. Apoptosis : an international journal on programmed cell death\| PubMed ID: 17453163	2007
Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death. The Journal of biological chemistry\| PubMed ID: 17537722	2007
The phosphorylation state of Drp1 determines cell fate. EMBO reports\| PubMed ID: 17906671	2007
Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice. The Journal of biological chemistry\| PubMed ID: 17984095	2008
Specific in vivo roles for E2Fs in differentiation and development. Cell cycle (Georgetown, Tex.)\| PubMed ID: 17993781	2007
The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18003894	2007
Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia. Journal of neurochemistry\| PubMed ID: 18205749	2008
Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18218782	2008
CITED2 signals through peroxisome proliferator-activated receptor-gamma to regulate death of cortical neurons after DNA damage. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18495890	2008
HES1 regulates 5-HT1A receptor gene transcription at a functional polymorphism: essential role in developmental expression. Molecular and cellular neurosciences\| PubMed ID: 18499474	2008
Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18550749	2008
E2F4 is required for early eye patterning. Developmental neuroscience\| PubMed ID: 19325228	2009
The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells. Molecular and cellular biology\| PubMed ID: 19564414	2009
Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Human molecular genetics\| PubMed ID: 19692353	2009
Mitochondria: joining forces to thwart cell death. Biochimica et biophysica acta\| PubMed ID: 19747972	2010
Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19812325	2009
Dining in with BCL-2: new guests at the autophagy table. Clinical science (London, England : 1979)\| PubMed ID: 19845510	2010
Pim-1 kinase as activator of the cell cycle pathway in neuronal death induced by DNA damage. Journal of neurochemistry\| PubMed ID: 19895669	2010
DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20133695	2010
Sertad1 plays an essential role in developmental and pathological neuron death. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20237268	2010
Reactive oxygen species: stuck in the middle of neurodegeneration. Journal of Alzheimer's disease : JAD\| PubMed ID: 20421690	2010
The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death. Nature cell biology\| PubMed ID: 20473298	2010
The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity. The Journal of biological chemistry\| PubMed ID: 21041314	2011
Rb/E2F regulates expression of neogenin during neuronal migration. Molecular and cellular biology\| PubMed ID: 21059867	2011
MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner. The EMBO journal\| PubMed ID: 21139567	2011
MCL-1 regulates the balance between autophagy and apoptosis. Autophagy\| PubMed ID: 21412051	2011
Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease ge... The Journal of biological chemistry\| PubMed ID: 22511790	2012
The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22699903	2012
ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons. Human molecular genetics\| PubMed ID: 22872702	2012
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy\| PubMed ID: 22966490	2012
Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23019375	2012
The retinoblastoma protein is essential for survival of postmitotic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23077065	2012
LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction. Human molecular genetics\| PubMed ID: 23187960	2013
Opposing regulation of Sox2 by cell-cycle effectors E2f3a and E2f3b in neural stem cells. Cell stem cell\| PubMed ID: 23499385	2013
Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23536090	2013
Perturbation of transcription factor Nur77 expression mediated by myocyte enhancer factor 2D (MEF2D) regulates dopaminergic neuron loss in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyr... The Journal of biological chemistry\| PubMed ID: 23536182	2013
LXCXE-independent chromatin remodeling by Rb/E2f mediates neuronal quiescence. Cell cycle (Georgetown, Tex.)\| PubMed ID: 23574720	2013
Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis. Molecular and cellular biology\| PubMed ID: 23689134	2013
Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival. Nature communications\| PubMed ID: 24686499	2014
Regulation of ischemic neuronal death by E2F4-p130 protein complexes. The Journal of biological chemistry\| PubMed ID: 24828495	2014
Regulation of the VHL/HIF-1 pathway by DJ-1. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24899725	2014
DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress. PloS one\| PubMed ID: 25210784	2014
OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand. The EMBO journal\| PubMed ID: 25298396	2014