Manu O. Platt

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University School of Medicine

Affiliated withGeorgia Institute of Technology & Emory University School of Medicine Georgia Institute of Technology

Research Area

Medicine

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2015

Other Publications

Article	Year
Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response. The Journal of biological chemistry\| PubMed ID: 12766166	2003
Heat shock and cold shock in Deinococcus radiodurans. Cell biochemistry and biophysics\| PubMed ID: 15211028	2004
Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxida... Circulation research\| PubMed ID: 15388638	2004
Simulated microgravity using the Random Positioning Machine inhibits differentiation and alters gene expression profiles of 2T3 preosteoblasts. American journal of physiology. Cell physiology\| PubMed ID: 15689415	2005
Laminar shear stress inhibits cathepsin L activity in endothelial cells. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 16709945	2006
Cyclic pressure and shear stress regulate matrix metalloproteinases and cathepsin activity in porcine aortic valves. The Journal of heart valve disease\| PubMed ID: 17044366	2006
Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosis. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17098827	2007
Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells. Journal of cellular physiology\| PubMed ID: 19544388	2009
Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells. Stem cells (Dayton, Ohio)\| PubMed ID: 19750537	2009
Detection of femtomole quantities of mature cathepsin K with zymography. Analytical biochemistry\| PubMed ID: 20206119	2010
Sickle cell biomechanics. Annual review of biomedical engineering\| PubMed ID: 20455701	2010
Multiplex zymography captures stage-specific activity profiles of cathepsins K, L, and S in human breast, lung, and cervical cancer. Journal of translational medicine\| PubMed ID: 21756348	2011
VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 21826315	2011
Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues. Archives of biochemistry and biophysics\| PubMed ID: 21982919	2011
T-cell phosphokinome as a fingerprint of effective graft versus leukemia. Frontiers in bioscience (Elite edition)\| PubMed ID: 22201908	2012
Sickle cell disease activates peripheral blood mononuclear cells to induce cathepsins k and v activity in endothelial cells. Anemia\| PubMed ID: 22550569	2012
Tumor necrosis factor alpha stimulates cathepsin K and V activity via juxtacrine monocyte-endothelial cell signaling and JNK activation. Molecular and cellular biochemistry\| PubMed ID: 22562303	2012
Cathepsin S cannibalism of cathepsin K as a mechanism to reduce type I collagen degradation. The Journal of biological chemistry\| PubMed ID: 22730330	2012
Patient specific proteolytic activity of monocyte-derived macrophages and osteoclasts predicted with temporal kinase activation states during differentiation. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 23114878	2012
Endothelial dysfunction, arterial stiffening, and intima-media thickening in large arteries from HIV-1 transgenic mice. Annals of biomedical engineering\| PubMed ID: 23180031	2013
Systematic optimization of multiplex zymography protocol to detect active cathepsins K, L, S, and V in healthy and diseased tissue: compromise among limits of detection, reduced time, and re... Molecular biotechnology\| PubMed ID: 23532386	2013
Azidothymidine (AZT) leads to arterial stiffening and intima-media thickening in mice. Journal of biomechanics\| PubMed ID: 23623314	2013
From GRID to gridlock: the relationship between scientific biomedical breakthroughs and HIV/AIDS policy in the US Congress. Journal of the International AIDS Society\| PubMed ID: 24286556	2013
Crohn's disease: a review of treatment options and current research. Cellular immunology\| PubMed ID: 24321565	2013
Pro-atherogenic shear stress and HIV proteins synergistically upregulate cathepsin K in endothelial cells. Annals of biomedical engineering\| PubMed ID: 24719048	2014
Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD. Blood\| PubMed ID: 25075126	2014
Identification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology. Circulation research\| PubMed ID: 25344555	2015
Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model. Annals of biomedical engineering\| PubMed ID: 25558848	2015