Leonard H. Augenlicht

Department of Medicine, Albert Einstein College of Medicine

Affiliated withAlbert Einstein College of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 17	2014

Other Publications

Article	Year
Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate. International journal of cancer. Journal international du cancer\| PubMed ID: 11774242	2002
A gene expression profile that defines colon cell maturation in vitro. Cancer research\| PubMed ID: 12183439	2002
Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer research\| PubMed ID: 12414619	2002
Short chain fatty acids and colon cancer. The Journal of nutrition\| PubMed ID: 12468628	2002
Environment-gene interactions in intestinal cancer. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)\| PubMed ID: 12570330	2002
Microarray analysis in the clinical management of cancer. Hematology/oncology clinics of North America\| PubMed ID: 12737394	2003
Application of gene expression profiling to colon cell maturation, transformation and chemoprevention. The Journal of nutrition\| PubMed ID: 12840217	2003
Gamma delta T cells provide an early source of interferon gamma in tumor immunity. The Journal of experimental medicine\| PubMed ID: 12900519	2003
Targeted inactivation of p27kip1 is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a Western-style high-risk diet. Cancer research\| PubMed ID: 12941825	2003
TR3/Nur77 in colon cancer cell apoptosis. Cancer research\| PubMed ID: 14500374	2003
The intrinsic mitochondrial membrane potential (Deltapsim) is associated with steady-state mitochondrial activity and the extent to which colonic epithelial cells undergo butyrate-mediated g... Cancer research\| PubMed ID: 14559818	2003
Spontaneous aberrant crypt foci in Apc1638N mice with a mutant Apc allele. The American journal of pathology\| PubMed ID: 14578176	2003
Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin. Cancer research\| PubMed ID: 14695196	2003
Tumor necrosis factor-alpha related gene response to Epothilone B in ovarian cancer. Gynecologic oncology\| PubMed ID: 15047209	2004
Customizing chemotherapy for colon cancer: the potential of gene expression profiling. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy\| PubMed ID: 15296862	2004
Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. Molecular and cellular biology\| PubMed ID: 15314168	2004
Methylation in the p21WAF1/cip1 promoter of Apc+/-, p21+/- mice and lack of response to sulindac. Oncogene\| PubMed ID: 15688007	2005
Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/- mice. The American journal of pathology\| PubMed ID: 15793302	2005
Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis. Gastroenterology\| PubMed ID: 15825089	2005
p27kip1 in intestinal tumorigenesis and chemoprevention in the mouse. Cancer research\| PubMed ID: 16230399	2005
The intrinsic mitochondrial membrane potential of colonic carcinoma cells is linked to the probability of tumor progression. Cancer research\| PubMed ID: 16267009	2005
Pathways in nutritional modulation of homeostasis and tumorigenesis. The Journal of nutrition\| PubMed ID: 16317165	2005
Kaiso-deficient mice show resistance to intestinal cancer. Molecular and cellular biology\| PubMed ID: 16354691	2006
Growth properties of colonic tumor cells are a function of the intrinsic mitochondrial membrane potential. Cancer research\| PubMed ID: 16452217	2006
Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer. The Journal of biological chemistry\| PubMed ID: 16533812	2006
Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16670197	2006
Interaction of genetic and dietary factors in mouse intestinal tumorigenesis. The Journal of nutrition\| PubMed ID: 16988154	2006
JNK1 is required for sulindac-mediated inhibition of cell proliferation and induction of apoptosis in vitro and in vivo. European journal of pharmacology\| PubMed ID: 17292881	2007
Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy. Cancer biology & therapy\| PubMed ID: 17387270	2007
c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. The American journal of pathology\| PubMed ID: 17591974	2007
p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: potential role in neoplasia. Gastroenterology\| PubMed ID: 17631145	2007
Sulindac suppresses beta-catenin expression in human cancer cells. European journal of pharmacology\| PubMed ID: 18291362	2008
PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer research\| PubMed ID: 18339877	2008
Expression of selenium-binding protein 1 characterizes intestinal cell maturation and predicts survival for patients with colorectal cancer. Molecular nutrition & food research\| PubMed ID: 18435490	2008
Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. Carcinogenesis\| PubMed ID: 18550571	2008
Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors. Cancer research\| PubMed ID: 18593893	2008
Intestinal deletion of Pofut1 in the mouse inactivates notch signaling and causes enterocolitis. Gastroenterology\| PubMed ID: 18621050	2008
HDAC4 promotes growth of colon cancer cells via repression of p21. Molecular biology of the cell\| PubMed ID: 18632985	2008
Proteomic changes during intestinal cell maturation in vivo. Journal of proteomics\| PubMed ID: 18824147	2008
Western-style diet-induced colonic tumors and their modulation by calcium and vitamin D in C57Bl/6 mice: a preclinical model for human sporadic colon cancer. Carcinogenesis\| PubMed ID: 19017685	2009
Butyrate and vitamin D3 induce transcriptional attenuation at the cyclin D1 locus in colonic carcinoma cells. Journal of cellular physiology\| PubMed ID: 19034928	2009
PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. Experimental cell research\| PubMed ID: 19232344	2009
An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased ... Cancer research\| PubMed ID: 19789347	2009
Gene expression profiling of primary and metastatic colon cancers identifies a reduced proliferative rate in metastatic tumors. Clinical & experimental metastasis\| PubMed ID: 19882219	2010
Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction. Cancer research\| PubMed ID: 20068171	2010
Altered dynamics of intestinal cell maturation in Apc1638N/+ mice. Cancer research\| PubMed ID: 20570902	2010
Oxaliplatin resistance induced by ERCC1 up-regulation is abrogated by siRNA-mediated gene silencing in human colorectal cancer cells. Anticancer research\| PubMed ID: 20682979	2010
Prediction and testing of biological networks underlying intestinal cancer. PloS one\| PubMed ID: 20824133	2010
Transcriptional attenuation in colon carcinoma cells in response to butyrate. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 20841488	2010
MYBL2, a link between proliferation and differentiation in maturing colon epithelial cells. Journal of cellular physiology\| PubMed ID: 20857481	2011
Paneth cell marker expression in intestinal villi and colon crypts characterizes dietary induced risk for mouse sporadic intestinal cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21652773	2011
Mybl2, downregulated during colon epithelial cell maturation, is suppressed by miR-365. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 21737779	2011
Stable differences in intrinsic mitochondrial membrane potential of tumor cell subpopulations reflect phenotypic heterogeneity. International journal of cell biology\| PubMed ID: 21760799	2011
Intestinal epithelial-specific PTEN inactivation results in tumor formation. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 21836055	2011
Intrinsic mitochondrial membrane potential and associated tumor phenotype are independent of MUC1 over-expression. PloS one\| PubMed ID: 21966455	2011
Dietary cholecalciferol and calcium levels in a Western-style defined rodent diet alter energy metabolism and inflammatory responses in mice. The Journal of nutrition\| PubMed ID: 22437564	2012
Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 23466815	2013
The effect of lung cancer on cytokine expression in peripheral blood mononuclear cells. PloS one\| PubMed ID: 23762239	2013
Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science (New York, N.Y.)\| PubMed ID: 24072822	2013
Circulating soluble cytokine receptors and colorectal cancer risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 24192010	2014
The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Krupp... The Journal of biological chemistry\| PubMed ID: 25037223	2014
Vitamin D is a Determinant of Mouse Intestinal Lgr5 Stem Cell Functions. Carcinogenesis\| PubMed ID: 25344836	2014