Lawrence S.B. Goldstein

Department of Cellular and Molecular Medicine, University of California San Diego

Affiliated withUniversity of California San Diego University of California San Diego School of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2014

Other Publications

Article	Year
Adociasulfates 1-6, Inhibitors of Kinesin Motor Proteins from the Sponge Haliclona (aka Adocia) sp. The Journal of organic chemistry\| PubMed ID: 11674622	1999
Principles of cargo attachment to cytoplasmic motor proteins. Current opinion in cell biology\| PubMed ID: 11792546	2002
A genetic screen for suppressors and enhancers of the Drosophila cdk1-cyclin B identifies maternal factors that regulate microtubule and microfilament stability. Genetics\| PubMed ID: 12454065	2002
Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12672950	2003
Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. The Journal of cell biology\| PubMed ID: 12682084	2003
JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Developmental cell\| PubMed ID: 12689591	2003
Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron\| PubMed ID: 14527431	2003
Do disorders of movement cause movement disorders and dementia? Neuron\| PubMed ID: 14556718	2003
Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease. Journal of neurobiology\| PubMed ID: 14704957	2004
Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction. Current opinion in cell biology\| PubMed ID: 15261678	2004
A standardized kinesin nomenclature. The Journal of cell biology\| PubMed ID: 15479732	2004
Polyglutamine diseases and transport problems: deadly traffic jams on neuronal highways. Archives of neurology\| PubMed ID: 15642849	2005
Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science (New York, N.Y.)\| PubMed ID: 15731448	2005
Sunday Driver links axonal transport to damage signaling. The Journal of cell biology\| PubMed ID: 15738268	2005
Kinesin-2 and photoreceptor cell death: requirement of motor subunits. Experimental eye research\| PubMed ID: 16337628	2006
Linking molecular motors to Alzheimer's disease. Journal of physiology, Paris\| PubMed ID: 16459060	2006
Axonal transport and Alzheimer's disease. Annual review of biochemistry\| PubMed ID: 16756504	2006
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron\| PubMed ID: 16815330	2006
The genetics of axonal transport and axonal transport disorders. PLoS genetics\| PubMed ID: 17009871	2006
Analysis of kinesin-2 function in photoreceptor cells using synchronous Cre-loxP knockout of Kif3a with RHO-Cre. Investigative ophthalmology & visual science\| PubMed ID: 17065525	2006
Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment. Molecular biology of the cell\| PubMed ID: 17360970	2007
Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18492803	2008
Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides. Human molecular genetics\| PubMed ID: 18694898	2008
Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19074039	2008
Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19420244	2009
Examination of potential mechanisms of amyloid-induced defects in neuronal transport. Neurobiology of disease\| PubMed ID: 19497367	2009
Sunday driver interacts with two distinct classes of axonal organelles. The Journal of biological chemistry\| PubMed ID: 19801628	2009
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes & development\| PubMed ID: 20516196	2010
Patients beware: commercialized stem cell treatments on the web. Cell stem cell\| PubMed ID: 20621049	2010
Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies. Human molecular genetics\| PubMed ID: 20817925	2010
Unconventional allies: interdisciplinary approaches to science policy and funding. Trends in cell biology\| PubMed ID: 21106464	2010
Investigating synapse formation and function using human pluripotent stem cell-derived neurons. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21278334	2011
Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles. Cell\| PubMed ID: 21335237	2011
Somatic coding mutations in human induced pluripotent stem cells. Nature\| PubMed ID: 21368825	2011
Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PloS one\| PubMed ID: 21407814	2011
A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. Molecular biology of the cell\| PubMed ID: 21880894	2011
Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds. Tissue engineering. Part A\| PubMed ID: 21883047	2011
In the trenches: lessons for scientists from California's Proposition 71 campaign. Molecular biology of the cell\| PubMed ID: 22039069	2011
Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism. PloS one\| PubMed ID: 22272245	2012
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature\| PubMed ID: 22278060	2012
Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila. Molecular biology of the cell\| PubMed ID: 22398725	2012
Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1. Human molecular genetics\| PubMed ID: 22437840	2012
Axonal transport and neurodegenerative disease: can we see the elephant? Progress in neurobiology\| PubMed ID: 22484448	2012
Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22582169	2012
Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects. Human molecular genetics\| PubMed ID: 22843498	2012
Alzheimer's disease in a dish: promises and challenges of human stem cell models. Human molecular genetics\| PubMed ID: 22865875	2012
An October call to arms: we are research! Molecular biology of the cell\| PubMed ID: 22936697	2012
New frontiers in human cell biology and medicine: can pluripotent stem cells deliver? The Journal of cell biology\| PubMed ID: 23148231	2012
ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23275297	2013
Endogenous GSK-3/shaggy regulates bidirectional axonal transport of the amyloid precursor protein. Traffic (Copenhagen, Denmark)\| PubMed ID: 23279138	2013
A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell stem cell\| PubMed ID: 23333150	2013
Using human-induced pluripotent stem cells to model monogenic metabolic disorders of the liver. Seminars in liver disease\| PubMed ID: 23397530	2012
Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo. Human molecular genetics\| PubMed ID: 23710041	2013
The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in Drosophila. PloS one\| PubMed ID: 23840848	2013
Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. The Journal of biological chemistry\| PubMed ID: 24145027	2013
The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells. Cell reports\| PubMed ID: 24239350	2013
Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function. Journal of cell science\| PubMed ID: 24522182	2014
UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24573290	2014
Biophysical challenges to axonal transport: motor-cargo deficiencies and neurodegeneration. Annual review of biophysics\| PubMed ID: 24702007	2014
Long-distance axonal growth from human induced pluripotent stem cells after spinal cord injury. Neuron\| PubMed ID: 25123310	2014
Effect of Potent γ-Secretase Modulator in Human Neurons Derived From Multiple Presenilin 1-Induced Pluripotent Stem Cell Mutant Carriers. JAMA neurology\| PubMed ID: 25285942	2014