Assaf Friedler

Institute of Chemistry, The Hebrew University of Jerusalem

Affiliated withThe Hebrew University of Jerusalem

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 18	2014

Other Publications

Article	Year
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11782540	2002
Inhibition of nuclear import by backbone cyclic peptidomimetics derived from the HIV-1 MA NLS sequence. Biochimica et biophysica acta\| PubMed ID: 11904219	2002
HIV-1 Vif-derived peptide inhibits drug-resistant HIV proteases. Biochemical and biophysical research communications\| PubMed ID: 11944889	2002
Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12124396	2002
Human immunodeficiency virus type 1 Vif binds the viral protease by interaction with its N-terminal region. The Journal of general virology\| PubMed ID: 12185277	2002
The structure of an FF domain from human HYPA/FBP11. Journal of molecular biology\| PubMed ID: 12381297	2002
Molecular mechanism of the interaction between MDM2 and p53. Journal of molecular biology\| PubMed ID: 12381304	2002
Kinetic instability of p53 core domain mutants: implications for rescue by small molecules. The Journal of biological chemistry\| PubMed ID: 12700230	2003
Cooperative organization in a macromolecular complex. Nature structural biology\| PubMed ID: 12897769	2003
Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14595027	2003
Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation". Journal of molecular biology\| PubMed ID: 14741214	2004
Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes. Journal of molecular biology\| PubMed ID: 14741215	2004
Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis. Protein science : a publication of the Protein Society\| PubMed ID: 14978302	2004
Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53. The Journal of biological chemistry\| PubMed ID: 15611070	2005
Modulation of binding of DNA to the C-terminal domain of p53 by acetylation. Structure (London, England : 1993)\| PubMed ID: 15837201	2005
Butyrylcholinesterase attenuates amyloid fibril formation in vitro. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16731619	2006
Interaction between HIV-1 Rev and integrase proteins: a basis for the development of anti-HIV peptides. The Journal of biological chemistry\| PubMed ID: 17403681	2007
Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17488811	2007
Expression and characterization of a novel reverse transcriptase of the LTR retrotransposon Tf1. Virology\| PubMed ID: 17524442	2007
The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome. The Journal of biological chemistry\| PubMed ID: 17827148	2007
Using peptides to study the interaction between the p53 tetramerization domain and HIV-1 Tat. Biopolymers\| PubMed ID: 18189286	2008
Correlation between shiftide activity and HIV-1 integrase inhibition by a peptide selected from a combinatorial library. Journal of molecular biology\| PubMed ID: 18201721	2008
Peptides derived from HIV-1 Rev inhibit HIV-1 integrase in a shiftide mechanism. Biopolymers\| PubMed ID: 18219678	2008
Synthesis of a novel macrocyclic library: discovery of an IGF-1R inhibitor. Journal of combinatorial chemistry\| PubMed ID: 18271560	2008
The structure and interactions of the proline-rich domain of ASPP2. The Journal of biological chemistry\| PubMed ID: 18448430	2008
Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18719108	2008
Design and synthesis of backbone cyclic phosphorylated peptides: The IkappaB model. Biopolymers\| PubMed ID: 19025995	2009
Peptides derived from HIV-1 integrase that bind Rev stimulate viral genome integration. PloS one\| PubMed ID: 19127291	2009
The C-terminal domain of the HIV-1 Vif protein is natively unfolded in its unbound state. Protein engineering, design & selection : PEDS\| PubMed ID: 19218568	2009
A model for the interaction between NF-kappa-B and ASPP2 suggests an I-kappa-B-like binding mechanism. Proteins\| PubMed ID: 19507243	2009
Peptide inhibitors of HIV-1 integrase: from mechanistic studies to improved lead compounds. Bioorganic & medicinal chemistry\| PubMed ID: 19850483	2009
Integration of HIV-1 DNA is regulated by interplay between viral rev and cellular LEDGF/p75 proteins. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 19855849	2010
Novel regulation of HIV-1 replication and pathogenicity: Rev inhibition of integration. Protein engineering, design & selection : PEDS\| PubMed ID: 19875511	2009
The positively charged region of the myosin IIC non-helical tailpiece promotes filament assembly. The Journal of biological chemistry\| PubMed ID: 19959848	2010
A novel role for the viral Rev protein in promoting resistance to superinfection by human immunodeficiency virus type 1. The Journal of general virology\| PubMed ID: 20147519	2010
Over-expression of the HIV-1 Rev promotes death of nondividing eukaryotic cells. Virus genes\| PubMed ID: 20151187	2010
Mechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361-370. Biochemical and biophysical research communications\| PubMed ID: 20171172	2010
Structural disorder in the HIV-1 Vif protein and interaction-dependent gain of structure. Protein and peptide letters\| PubMed ID: 20450485	2010
Peptide-modified "smart" hydrogels and genetically engineered stem cells for skeletal tissue engineering. Biomacromolecules\| PubMed ID: 20462241	2010
Stimulation of the HIV-1 integrase enzymatic activity and cDNA integration by a peptide derived from the integrase protein. Biopolymers\| PubMed ID: 20517955	2010
The ASPP interaction network: electrostatic differentiation between pro- and anti-apoptotic proteins. Journal of molecular recognition : JMR\| PubMed ID: 20623514	2011
Oxidation of Helix-3 methionines precedes the formation of PK resistant PrP. PLoS pathogens\| PubMed ID: 20625387	2010
The C terminus of p53 binds the N-terminal domain of MDM2. Nature structural & molecular biology\| PubMed ID: 20639885	2010
Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells. Virology journal\| PubMed ID: 20678206	2010
Specific eradication of HIV-1 from infected cultured cells. AIDS research and therapy\| PubMed ID: 20723214	2010
A family of cell-adhering peptides homologous to fibrinogen C-termini. Biochemical and biophysical research communications\| PubMed ID: 20833137	2010
Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein. Bioorganic & medicinal chemistry\| PubMed ID: 20974536	2010
From peptides to proteins: lessons from my years at the Centre for Protein Engineering. Protein engineering, design & selection : PEDS\| PubMed ID: 21062759	2011
Critical scaffolding regions of the tumor suppressor Axin1 are natively unfolded. Journal of molecular biology\| PubMed ID: 21087614	2011
Peptides that bind the HIV-1 integrase and modulate its enzymatic activity--kinetic studies and mode of action. The FEBS journal\| PubMed ID: 21156026	2011
Studying protein-protein interactions using peptide arrays. Chemical Society reviews\| PubMed ID: 21243154	2011
Crowding alone cannot account for cosolute effect on amyloid aggregation. PloS one\| PubMed ID: 21249221	2011
Transportin 3 and importin α are required for effective nuclear import of HIV-1 integrase in virus-infected cells. Nucleus (Austin, Tex.)\| PubMed ID: 21326825	2010
Nucleocytoplasmic shuttling of HIV-1 integrase is controlled by the viral Rev protein. Nucleus (Austin, Tex.)\| PubMed ID: 21326951	2010
The effect of tachykinin neuropeptides on amyloid β aggregation. Biochemical and biophysical research communications\| PubMed ID: 21352807	2011
Using peptides to study protein-protein interactions. Future medicinal chemistry\| PubMed ID: 21426115	2010
Chemical synthesis and expression of the HIV-1 Rev protein. Chembiochem : a European journal of chemical biology\| PubMed ID: 21488138	2011
Mechanism of the interaction between the intrinsically disordered C-terminus of the pro-apoptotic ARTS protein and the Bir3 domain of XIAP. PloS one\| PubMed ID: 21949740	2011
Exposure of bipartite hydrophobic signal triggers nuclear quality control of Ndc10 at the endoplasmic reticulum/nuclear envelope. Molecular biology of the cell\| PubMed ID: 21998200	2011
A structural model of the HIV-1 Rev-integrase complex: the molecular basis of integrase regulation by Rev. Biochemical and biophysical research communications\| PubMed ID: 22093836	2011
Peptides mimicking the unique ARTS-XIAP binding site promote apoptotic cell death in cultured cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22392914	2012
Molecular basis of the interaction between proapoptotic truncated BID (tBID) protein and mitochondrial carrier homologue 2 (MTCH2) protein: key players in mitochondrial death pathway. The Journal of biological chemistry\| PubMed ID: 22416135	2012
A comparative study of backbone versus side chain peptide cyclization: application for HIV-1 integrase inhibitors. Bioorganic & medicinal chemistry\| PubMed ID: 22507205	2012
Specific recognition of p53 tetramers by peptides derived from p53 interacting proteins. PloS one\| PubMed ID: 22693587	2012
Peptides that inhibit HIV-1 integrase by blocking its protein-protein interactions. The FEBS journal\| PubMed ID: 22742518	2012
Revealing the ligand binding site of NhaA Na+/H+ antiporter and its pH dependence. The Journal of biological chemistry\| PubMed ID: 22915592	2012
High resolution characterization of myosin IIC protein tailpiece and its effect on filament assembly. The Journal of biological chemistry\| PubMed ID: 23426373	2013
Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system. Chemical communications (Cambridge, England)\| PubMed ID: 23463374	2013
Regulation of ASPP2 interaction with p53 core domain by an intramolecular autoinhibitory mechanism. PloS one\| PubMed ID: 23472201	2013
Mapping the Vif-A3G interaction using peptide arrays: a basis for anti-HIV lead peptides. Bioorganic & medicinal chemistry\| PubMed ID: 23545135	2013
The STIL protein contains intrinsically disordered regions that mediate its protein-protein interactions. Chemical communications (Cambridge, England)\| PubMed ID: 24022511	2014
Characterization of the translocation-competent complex between the Helicobacter pylori oncogenic protein CagA and the accessory protein CagF. The Journal of biological chemistry\| PubMed ID: 24072713	2013
acetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitro. PloS one\| PubMed ID: 24194938	2013
A highly efficient in situ N-acetylation approach for solid phase synthesis. Organic & biomolecular chemistry\| PubMed ID: 24526269	2014
Cation diffusion facilitators transport initiation and regulation is mediated by cation induced conformational changes of the cytoplasmic domain. PloS one\| PubMed ID: 24658343	2014
Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24706857	2014
Allosteric modulation of protein oligomerization: an emerging approach to drug design. Frontiers in chemistry\| PubMed ID: 24790978	2014
Bacterial magnetosome biomineralization--a novel platform to study molecular mechanisms of human CDF-related Type-II diabetes. PloS one\| PubMed ID: 24819161	2014
A tandem in situ peptide cyclization through trifluoroacetic acid cleavage. Angewandte Chemie (International ed. in English)\| PubMed ID: 24827640	2014
A role of disordered domains in regulating protein oligomerization and stability. Chemical communications (Cambridge, England)\| PubMed ID: 25054624	2014
The disordered region of Arabidopsis VIP1 binds the Agrobacterium VirE2 protein outside its DNA-binding site. Protein engineering, design & selection : PEDS\| PubMed ID: 25212215	2014