Stuart H. Orkin

Harvard Medical School

Affiliated withHarvard Medical School Boston Children's Hospital Dana-Farber Cancer Institute

Research Area

Biography

Stuart H. Orkin has not added Biography.
If you are Stuart H. Orkin and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 159	2015

Other Publications

Article	Year
Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. Blood\| PubMed ID: 14504093	2004
The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages. Genes & development\| PubMed ID: 11825872	2002
The search for the hemangioblast. Journal of hematotherapy & stem cell research\| PubMed ID: 11847000	2002
Hematopoiesis and stem cells: plasticity versus developmental heterogeneity. Nature immunology\| PubMed ID: 11919568	2002
Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo. Molecular and cellular biology\| PubMed ID: 11940669	2002
Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation. Molecular and cellular biology\| PubMed ID: 12024038	2002
Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene\| PubMed ID: 12032775	2002
Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. The Journal of experimental medicine\| PubMed ID: 12045237	2002
The use of altered specificity mutants to probe specific protein-protein interactions involved in the activation of GATA-1 target genes. Methods (San Diego, Calif.)\| PubMed ID: 12054907	2002
GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12077323	2002
Stem-cell competition. Nature\| PubMed ID: 12097889	2002
X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. Blood\| PubMed ID: 12200364	2002
Dysregulation of protein modification by ISG15 results in brain cell injury. Genes & development\| PubMed ID: 12208842	2002
Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Development (Cambridge, England)\| PubMed ID: 12223418	2002
The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. Blood\| PubMed ID: 12239153	2002
Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood\| PubMed ID: 12393529	2003
The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development (Cambridge, England)\| PubMed ID: 12441305	2003
Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. Cancer cell\| PubMed ID: 12450796	2002
Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity\| PubMed ID: 12530980	2003
Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature\| PubMed ID: 12540851	2003
GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant. The Journal of experimental medicine\| PubMed ID: 12566412	2003
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature\| PubMed ID: 12891360	2003
Combinatorial interactions of serpent, lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14504400	2003
Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14614148	2003
Priming the hematopoietic pump. Immunity\| PubMed ID: 14614848	2003
Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14715908	2004
More than blood, a novel gene required for mammalian postimplantation development. Molecular and cellular biology\| PubMed ID: 14729962	2004
The SWI/SNF complex--chromatin and cancer. Nature reviews. Cancer\| PubMed ID: 14964309	2004
Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Molecular and cellular biology\| PubMed ID: 14966286	2004
Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis. The Journal of biological chemistry\| PubMed ID: 15037632	2004
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer cell\| PubMed ID: 15093544	2004
Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. Molecular and cellular biology\| PubMed ID: 15314159	2004
The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS biology\| PubMed ID: 15314655	2004
Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes & development\| PubMed ID: 15371326	2004
A critical role for eosinophils in allergic airways remodeling. Science (New York, N.Y.)\| PubMed ID: 15375268	2004
Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature\| PubMed ID: 15457180	2004
GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. The Journal of experimental medicine\| PubMed ID: 15466621	2004
Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome research\| PubMed ID: 15489339	2004
Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse. Methods in molecular medicine\| PubMed ID: 15492385	2005
Enforced expression of PU.1 rescues osteoclastogenesis from embryonic stem cells lacking Tal-1. Stem cells (Dayton, Ohio)\| PubMed ID: 15625130	2005
Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins. Seminars in cell & developmental biology\| PubMed ID: 15659346	2005
Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development. Blood\| PubMed ID: 15677556	2005
The placenta is a niche for hematopoietic stem cells. Developmental cell\| PubMed ID: 15737932	2005
Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood\| PubMed ID: 15811962	2005
Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. Science (New York, N.Y.)\| PubMed ID: 15894532	2005
Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nature genetics\| PubMed ID: 15895080	2005
Stem cells: the road not taken. Nature\| PubMed ID: 15931202	2005
The transcription factor GATA2 regulates differentiation of brown adipocytes. EMBO reports\| PubMed ID: 16082385	2005
Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation. Molecular and cellular biology\| PubMed ID: 16107690	2005
Placenta as a site for hematopoietic stem cell development. Experimental hematology\| PubMed ID: 16140153	2005
Chipping away at the embryonic stem cell network. Cell\| PubMed ID: 16179251	2005
Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube. Nature\| PubMed ID: 16292311	2005
Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells. Current opinion in hematology\| PubMed ID: 16319680	2006
Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo. Blood\| PubMed ID: 16391009	2006
Reactions to the Hwang scandal. Science (New York, N.Y.)\| PubMed ID: 16459360	2006
Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16492768	2006
Characterization of a megakaryocyte-specific enhancer of the key hemopoietic transcription factor GATA1. The Journal of biological chemistry\| PubMed ID: 16551635	2006
Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitors. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16621992	2006
Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16754850	2006
Unraveling the transcriptional network controlling ES cell pluripotency. Genome biology\| PubMed ID: 16942632	2006
The journey of developing hematopoietic stem cells. Development (Cambridge, England)\| PubMed ID: 16968814	2006
The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor. Blood\| PubMed ID: 17038527	2007
A protein interaction network for pluripotency of embryonic stem cells. Nature\| PubMed ID: 17093407	2006
Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell\| PubMed ID: 17123591	2006
Gata4 is necessary for normal pulmonary lobar development. American journal of respiratory cell and molecular biology\| PubMed ID: 17142311	2007
Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell\| PubMed ID: 17574022	2007
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature\| PubMed ID: 17581586	2007
Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Molecular cell\| PubMed ID: 17707228	2007
Immunology: changed destiny. Nature\| PubMed ID: 17898754	2007
ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. Cancer cell\| PubMed ID: 18068631	2007
Site-directed, virus-free, and inducible RNAi in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18093939	2007
A protein roadmap to pluripotency and faithful reprogramming. Cells, tissues, organs\| PubMed ID: 18196921	2008
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18245381	2008
Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes & development\| PubMed ID: 18258751	2008
Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells. Genes & development\| PubMed ID: 18283123	2008
Hematopoiesis: an evolving paradigm for stem cell biology. Cell\| PubMed ID: 18295580	2008
SnapShot: hematopoiesis. Cell\| PubMed ID: 18295585	2008
Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. The Journal of experimental medicine\| PubMed ID: 18299398	2008
PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nature genetics\| PubMed ID: 18311137	2008
An extended transcriptional network for pluripotency of embryonic stem cells. Cell\| PubMed ID: 18358816	2008
The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell stem cell\| PubMed ID: 18371450	2008
Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis. Molecular and cellular biology\| PubMed ID: 18391014	2008
Stem cells down under-ISSCR 2007. Cell stem cell\| PubMed ID: 18399027	2007
Requirement of Nanog dimerization for stem cell self-renewal and pluripotency. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18436640	2008
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes & development\| PubMed ID: 18559481	2008
DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18667698	2008
GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. Developmental biology\| PubMed ID: 18692040	2008
Rb and hematopoiesis: stem cells to anemia. Cell division\| PubMed ID: 18775080	2008
Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Developmental cell\| PubMed ID: 18848501	2008
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Molecular cell\| PubMed ID: 19026780	2008
Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science (New York, N.Y.)\| PubMed ID: 19056937	2008
ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nature immunology\| PubMed ID: 19060901	2009
Glimpses of the epigenetic landscape. Cell stem cell\| PubMed ID: 19128786	2009
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood\| PubMed ID: 19211936	2009
Tandem affinity purification of protein complexes in mouse embryonic stem cells using in vivo biotinylation. Current protocols in stem cell biology\| PubMed ID: 19306258	2009
Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. Nature protocols\| PubMed ID: 19325547	2009
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes & development\| PubMed ID: 19339689	2009
Musings on genome medicine: abuse of genetic tests. Genome medicine\| PubMed ID: 19341489	2009
Musings on genome medicine: the Obama effect. Genome medicine\| PubMed ID: 19341501	2009
Musings on genome medicine: genome wide association studies. Genome medicine\| PubMed ID: 19348690	2009
Musings on genome medicine: gene therapy. Genome medicine\| PubMed ID: 19435468	2009
Musings on genome medicine: cancer genetics and the promise of effective treatment. Genome medicine\| PubMed ID: 19439059	2009
Musings on genome medicine: cholesterol and coronary artery disease. Genome medicine\| PubMed ID: 19519958	2009
TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia. Cell stem cell\| PubMed ID: 19570513	2009
GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Molecular and cellular biology\| PubMed ID: 19620289	2009
Translational isoforms of FOG1 regulate GATA1-interacting complexes. The Journal of biological chemistry\| PubMed ID: 19654328	2009
Developmental and species-divergent globin switching are driven by BCL11A. Nature\| PubMed ID: 19657335	2009
Musings on genome medicine: the Obama effect redux. Genome medicine\| PubMed ID: 19769781	2009
DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell stem cell\| PubMed ID: 19796624	2009
Musings on genome medicine: the slow but inexorable process of medical care reform in the United States. Genome medicine\| PubMed ID: 19822025	2009
Musings on genome medicine: Crohn's disease. Genome medicine\| PubMed ID: 19891793	2009
Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Molecular cell\| PubMed ID: 19941827	2009
Musings on genome medicine: enzyme-replacement therapy of the lysosomal storage diseases. Genome medicine\| PubMed ID: 20017892	2009
Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell\| PubMed ID: 20064376	2009
Systematic tracking of cell fate changes. Nature biotechnology\| PubMed ID: 20139953	2010
Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood\| PubMed ID: 20154221	2010
Musings on genome medicine: Hepatitis C. Genome medicine\| PubMed ID: 20193049	2010
miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes & development\| PubMed ID: 20194440	2010
Advances in the understanding of haemoglobin switching. British journal of haematology\| PubMed ID: 20201948	2010
DNA methylation in adult stem cells: new insights into self-renewal. Epigenetics : official journal of the DNA Methylation Society\| PubMed ID: 20364115	2010
Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes & development\| PubMed ID: 20395365	2010
Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP). The Journal of biological chemistry\| PubMed ID: 20587419	2010
TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell\| PubMed ID: 20603019	2010
Medicine. Sickle cell disease at 100 years. Science (New York, N.Y.)\| PubMed ID: 20647458	2010
Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. Genes & development\| PubMed ID: 20679399	2010
Transcriptional silencing of fetal hemoglobin by BCL11A. Annals of the New York Academy of Sciences\| PubMed ID: 20712774	2010
Training program in cancer and blood diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute. American journal of hematology\| PubMed ID: 20730793	2010
Differential roles of Sall4 isoforms in embryonic stem cell pluripotency. Molecular and cellular biology\| PubMed ID: 20837710	2010
A single cis element maintains repression of the key developmental regulator Gata2. PLoS genetics\| PubMed ID: 20838598	2010
A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell\| PubMed ID: 20946988	2010
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer cell\| PubMed ID: 20951942	2010
Modifier genes in Mendelian disorders: the example of hemoglobin disorders. Annals of the New York Academy of Sciences\| PubMed ID: 21039591	2010
Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation. Nature genetics\| PubMed ID: 21057501	2010
Networking erythropoiesis. The Journal of experimental medicine\| PubMed ID: 21098097	2010
Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer. Blood\| PubMed ID: 21156846	2011
Update on fetal hemoglobin gene regulation in hemoglobinopathies. Current opinion in pediatrics\| PubMed ID: 21157349	2011
MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21205891	2011
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell stem cell\| PubMed ID: 21295276	2011
Context-dependent function of "GATA switch" sites in vivo. Blood\| PubMed ID: 21398579	2011
The erythroid/myeloid lineage fate paradigm takes a new player. The EMBO journal\| PubMed ID: 21407249	2011
Genome Medicine: stem cells, genomics and translational research. Genome medicine\| PubMed ID: 21658298	2011
Chromatin connections to pluripotency and cellular reprogramming. Cell\| PubMed ID: 21663790	2011
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21788502	2011
MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21849676	2011
A functional element necessary for fetal hemoglobin silencing. The New England journal of medicine\| PubMed ID: 21879898	2011
Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells. Stem cells (Dayton, Ohio)\| PubMed ID: 21915945	2011
Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science (New York, N.Y.)\| PubMed ID: 21998251	2011
Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine. Genome medicine\| PubMed ID: 22126538	2011
Polycomb repressive complex 2 regulates normal development of the mouse heart. Circulation research\| PubMed ID: 22158708	2012
Dnmt3a silences hematopoietic stem cell self-renewal. Nature genetics\| PubMed ID: 22200773	2012
PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes & development\| PubMed ID: 22215809	2012
A human stem cell model of early Alzheimer's disease pathology in Down syndrome. Science translational medicine\| PubMed ID: 22344463	2012
MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Science translational medicine\| PubMed ID: 22344686	2012
Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes & development\| PubMed ID: 22345515	2012
MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation\| PubMed ID: 22371328	2012
Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22396593	2012
MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. Genome biology\| PubMed ID: 22424423	2012
Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. The Journal of clinical investigation\| PubMed ID: 22706301	2012
The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo. Molecular and cellular biology\| PubMed ID: 22711990	2012
Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell\| PubMed ID: 22863011	2012
Reawakening fetal hemoglobin: prospects for new therapies for the Î²-globin disorders. Blood\| PubMed ID: 22904296	2012
Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes & development\| PubMed ID: 22929040	2012
Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. Developmental cell\| PubMed ID: 23041383	2012
Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23045682	2012
TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Developmental biology\| PubMed ID: 23159334	2013
The switch from fetal to adult hemoglobin. Cold Spring Harbor perspectives in medicine\| PubMed ID: 23209159	2013
Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. Molecular cell\| PubMed ID: 23395001	2013
Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis. Current opinion in genetics & development\| PubMed ID: 23477921	2013
ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes & development\| PubMed ID: 23512661	2013
Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23576758	2013
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. eLife\| PubMed ID: 23795291	2013
Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23824294	2013
Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nature chemical biology\| PubMed ID: 23974116	2013
Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. Cell stem cell\| PubMed ID: 24035353	2013
An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science (New York, N.Y.)\| PubMed ID: 24115442	2013
Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell stem cell\| PubMed ID: 24239285	2014
Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. Molecular cell\| PubMed ID: 24361252	2014
Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation. Developmental cell\| PubMed ID: 24369834	2013
Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24395799	2014
Corepressor Rcor1 is essential for murine erythropoiesis. Blood\| PubMed ID: 24652990	2014
Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. The Journal of experimental medicine\| PubMed ID: 24711581	2014
Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell\| PubMed ID: 24766805	2014
Characterization of genomic deletion efficiency mediated by clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. The Journal of biological chemistry\| PubMed ID: 24907273	2014
TMEM14C is required for erythroid mitochondrial heme metabolism. The Journal of clinical investigation\| PubMed ID: 25157825	2014
Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F. The Journal of experimental medicine\| PubMed ID: 25288396	2014
Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. Genes & development\| PubMed ID: 25395663	2014
A comparative encyclopedia of DNA elements in the mouse genome. Nature\| PubMed ID: 25409824	2014
Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution. Science (New York, N.Y.)\| PubMed ID: 25411453	2014
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25512523	2014
Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis. Genome biology\| PubMed ID: 25517911	2014