David G. Harrison

Department of Medicine, Emory University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 83	2010

Other Publications

Article	Year
The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: part I: oxidative stress and atherogenesis. Circulation\| PubMed ID: 11804998	2002
The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: Part II: AT(1) receptor regulation. Circulation\| PubMed ID: 11815439	2002
Geldanamycin leads to superoxide formation by enzymatic and non-enzymatic redox cycling. Implications for studies of Hsp90 and endothelial cell nitric-oxide synthase. The Journal of biological chemistry\| PubMed ID: 11983711	2002
Free radicals in heart failure: therapeutic targets for old and new drugs. Congestive heart failure (Greenwich, Conn.)\| PubMed ID: 12045380	2002
Extracellular superoxide dismutase and cardiovascular disease. Cardiovascular research\| PubMed ID: 12123763	2002
Maintenance of a functional endothelial cell monolayer on a fibroblast/polymer substrate under physiologically relevant shear stress conditions. Tissue engineering\| PubMed ID: 12202008	2002
Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 12231557	2002
Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. Hypertension\| PubMed ID: 12364355	2002
NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production in response to angiotensin II. The Journal of biological chemistry\| PubMed ID: 12377764	2002
Detection of superoxide in vascular tissue. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 12426202	2002
Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke. Circulation\| PubMed ID: 12451014	2002
Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase. Circulation\| PubMed ID: 12473554	2002
Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-... Molecular pharmacology\| PubMed ID: 12527803	2003
Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12595302	2003
Electron spin resonance characterization of vascular xanthine and NAD(P)H oxidase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation. Circulation\| PubMed ID: 12642358	2003
Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. The Journal of biological chemistry\| PubMed ID: 12692136	2003
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. The Journal of clinical investigation\| PubMed ID: 12697739	2003
Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease. Journal of the renin-angiotensin-aldosterone system : JRAAS\| PubMed ID: 12806586	2003
Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12958034	2003
Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion. The Journal of biological chemistry\| PubMed ID: 12958309	2003
The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases. Trends in pharmacological sciences\| PubMed ID: 12967772	2003
Shear stress regulates endothelial nitric-oxide synthase promoter activity through nuclear factor kappaB binding. The Journal of biological chemistry\| PubMed ID: 14570928	2004
Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase. Free radical biology & medicine\| PubMed ID: 14583337	2003
Endothelial control of vasomotion and nitric oxide production. Cardiology clinics\| PubMed ID: 14621446	2003
Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma. Circulation\| PubMed ID: 14744973	2004
C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils. Hypertension\| PubMed ID: 15078863	2004
Established and emerging plasma biomarkers in the prediction of first atherothrombotic events. Circulation\| PubMed ID: 15226246	2004
Oscillatory shear stress upregulation of endothelial nitric oxide synthase requires intracellular hydrogen peroxide and CaMKII. Journal of molecular and cellular cardiology\| PubMed ID: 15242742	2004
Oxidative stress and diabetic vascular complications. Current diabetes reports\| PubMed ID: 15265465	2004
Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay. American journal of physiology. Cell physiology\| PubMed ID: 15306539	2004
Angiotensin II-induced hypertrophy is potentiated in mice overexpressing p22phox in vascular smooth muscle. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15345488	2005
Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15471976	2005
ATVB in focus: redox mechanisms in blood vessels. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 15514203	2005
Association between novel oxidative stress markers and C-reactive protein among adults without clinical coronary heart disease. Atherosclerosis\| PubMed ID: 15585208	2005
Critical involvement of hydrogen peroxide in exercise-induced up-regulation of endothelial NO synthase. Cardiovascular research\| PubMed ID: 15621054	2005
Role of antioxidant-1 in extracellular superoxide dismutase function and expression. Circulation research\| PubMed ID: 15761197	2005
The shear stress of keeping arteries clear. Nature medicine\| PubMed ID: 15812513	2005
Laminar shear stress and 3' polyadenylation of eNOS mRNA. Circulation research\| PubMed ID: 15905462	2005
Regulation of xanthine oxidoreductase protein expression by hydrogen peroxide and calcium. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 15905466	2005
Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase. Biochemical pharmacology\| PubMed ID: 15963955	2005
A negative feedback mechanism involving nitric oxide and nuclear factor kappa-B modulates endothelial nitric oxide synthase transcription. Journal of molecular and cellular cardiology\| PubMed ID: 16099468	2005
The role of the multidrug resistance protein-1 in modulation of endothelial cell oxidative stress. Circulation research\| PubMed ID: 16123331	2005
Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases. Circulation\| PubMed ID: 16129811	2005
Can vitamin E prevent cardiovascular events and cancer? Nature clinical practice. Cardiovascular medicine\| PubMed ID: 16186847	2005
Coronary artery superoxide production and nox isoform expression in human coronary artery disease. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 16293794	2006
RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response. Hypertension\| PubMed ID: 16391171	2006
The relationship between plasma levels of oxidized and reduced thiols and early atherosclerosis in healthy adults. Journal of the American College of Cardiology\| PubMed ID: 16516085	2006
Vascular NADPH oxidases as drug targets for novel antioxidant strategies. Drug discovery today\| PubMed ID: 16713904	2006
Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation. Circulation\| PubMed ID: 16769910	2006
Role of extracellular superoxide dismutase in hypertension. Hypertension\| PubMed ID: 16864745	2006
Early determinants of H2O2-induced endothelial dysfunction. Free radical biology & medicine\| PubMed ID: 16895801	2006
Angiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia, and attenuated angiotensin response. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17148616	2006
Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetes. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17237245	2007
Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 17272743	2007
Measurement of reactive oxygen species in cardiovascular studies. Hypertension\| PubMed ID: 17296874	2007
Endothelial NF-kappaB as a mediator of kidney damage: the missing link between systemic vascular and renal disease? Circulation research\| PubMed ID: 17673681	2007
Regulation of tetrahydrobiopterin biosynthesis by shear stress. Circulation research\| PubMed ID: 17704208	2007
Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. The Journal of experimental medicine\| PubMed ID: 17875676	2007
Sad heart from no SOD. Hypertension\| PubMed ID: 18025292	2008
Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction. Circulation research\| PubMed ID: 18096818	2008
Detection of reactive oxygen species and nitric oxide in vascular cells and tissues: comparison of sensitivity and specificity. Methods in molecular medicine\| PubMed ID: 18287681	2007
Activation of p300 histone acetyltransferase activity is an early endothelial response to laminar shear stress and is essential for stimulation of endothelial nitric-oxide synthase mRNA tran... The Journal of biological chemistry\| PubMed ID: 18397880	2008
Endothelial function and aminothiol biomarkers of oxidative stress in healthy adults. Hypertension\| PubMed ID: 18504327	2008
Enhanced hype. The American journal of cardiology\| PubMed ID: 18638604	2008
Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production. Free radical biology & medicine\| PubMed ID: 18760347	2008
Role of Menkes ATPase in angiotensin II-induced hypertension: a key modulator for extracellular superoxide dismutase function. Hypertension\| PubMed ID: 18768397	2008
Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome. The American journal of pathology\| PubMed ID: 18787098	2008
Is hypertension an immunologic disease? Current cardiology reports\| PubMed ID: 18950555	2008
Doubt about an essential role for constitutive nitric oxide synthase in nitroglycerin-mediated vasodilation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19020103	2008
Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxidase contributes to vascular oxidative stress in human coronary artery disease. Journal of the American College of Cardiology\| PubMed ID: 19022160	2008
Regulation of T-cell function by endogenously produced angiotensin II. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 19073907	2009
Molecular beacons can assess changes in expression and 3'-polyadenylation of human eNOS mRNA. American journal of physiology. Cell physiology\| PubMed ID: 19109525	2009
Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes. Circulation research\| PubMed ID: 19265038	2009
Blood pressure control: salt gets under your skin. Nature medicine\| PubMed ID: 19424204	2009
Oxidative stress and hypertension. The Medical clinics of North America\| PubMed ID: 19427495	2009
Targeted detoxification of selected reactive oxygen species in the vascular endothelium. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 19692634	2009
GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide. Circulation research\| PubMed ID: 19926872	2010
Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system. Hypertension\| PubMed ID: 20008675	2010
Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction. Hypertension\| PubMed ID: 20038749	2010
Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction. Circulation\| PubMed ID: 20083682	2010
NO solution for a radical problem: a TAL story. American journal of physiology. Renal physiology\| PubMed ID: 20130124	2010
Role of the adaptive immune system in hypertension. Current opinion in pharmacology\| PubMed ID: 20167535	2010
Oxidative stress and hypertension. Journal of the American Society of Hypertension : JASH\| PubMed ID: 20409831	2007
Inflammatory markers and incident heart failure risk in older adults: the Health ABC (Health, Aging, and Body Composition) study. Journal of the American College of Cardiology\| PubMed ID: 20447537	2010
Therapeutic targeting of mitochondrial superoxide in hypertension. Circulation research\| PubMed ID: 20448215	2010
Protective role of extracellular superoxide dismutase in renal ischemia/reperfusion injury. Kidney international\| PubMed ID: 20505656	2010
Central and peripheral mechanisms of T-lymphocyte activation and vascular inflammation produced by angiotensin II-induced hypertension. Circulation research\| PubMed ID: 20558826	2010
Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 20639222	2010
Regulation of endothelial cell tetrahydrobiopterin pathophysiological and therapeutic implications. Advances in pharmacology (San Diego, Calif.)\| PubMed ID: 21081217	2010
Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension. Circulation\| PubMed ID: 21126972	2010
Inflammation, immunity, and hypertension. Hypertension\| PubMed ID: 21149826	2011
The central nervous system and inflammation in hypertension. Current opinion in pharmacology\| PubMed ID: 21196131	2011
Role of increased guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation. The Journal of biological chemistry\| PubMed ID: 21343293	2011
Localization of culprit lesions in coronary arteries of patients with ST-segment elevation myocardial infarctions: relation to bifurcations and curvatures. American heart journal\| PubMed ID: 21392605	2011
Just not himself these days: an invitation to submit papers on the topic of inflammation and immunity in organ systems physiology and pathophysiology. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 21474428	2011
Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21474820	2011
Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flow. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21512164	2011
A novel high-throughput screening assay for discovery of molecules that increase cellular tetrahydrobiopterin. Journal of biomolecular screening\| PubMed ID: 21693765	2011
Role of vascular extracellular superoxide dismutase in hypertension. Hypertension\| PubMed ID: 21730294	2011
Requirement of argininosuccinate lyase for systemic nitric oxide production. Nature medicine\| PubMed ID: 22081021	2011
What fans the fire: insights into mechanisms of inflammation in atherosclerosis and diabetes mellitus. Circulation\| PubMed ID: 22184043	2011