Hanjoong Jo

Department of Medicine, Emory University

Affiliated withEmory University Georgia Tech and Emory University Ewha Womans University

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 83	2010
Publication title Cited by 7	2021

Other Publications

Article	Year
Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A. The Journal of biological chemistry\| PubMed ID: 11729190	2002
Activation of c-Jun N-terminal kinase and apoptosis in endothelial cells mediated by endogenous generation of hydrogen peroxide. Biological chemistry\| PubMed ID: 12033458	2002
Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. Hypertension\| PubMed ID: 12364355	2002
NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production in response to angiotensin II. The Journal of biological chemistry\| PubMed ID: 12377764	2002
Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12384459	2002
Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide s... The Journal of biological chemistry\| PubMed ID: 12591925	2003
IkappaBalpha-dependent regulation of low-shear flow-induced NF-kappa B activity: role of nitric oxide. American journal of physiology. Cell physiology\| PubMed ID: 12620896	2003
Chronic shear induces caveolae formation and alters ERK and Akt responses in endothelial cells. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12763750	2003
Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response. The Journal of biological chemistry\| PubMed ID: 12766166	2003
Optimization of isolation and functional characterization of primary murine aortic endothelial cells. Endothelium : journal of endothelial cell research\| PubMed ID: 12791518	2003
A role for PYK2 in ANG II-dependent regulation of the PHAS-1-eIF4E complex by multiple signaling cascades in vascular smooth muscle. American journal of physiology. Cell physiology\| PubMed ID: 12890645	2003
Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases. American journal of physiology. Cell physiology\| PubMed ID: 12900384	2003
Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12958034	2003
Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion. The Journal of biological chemistry\| PubMed ID: 12958309	2003
Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase. Free radical biology & medicine\| PubMed ID: 14583337	2003
High glucose induced NF-kappaB DNA-binding activity in HAEC is maintained under low shear stress but inhibited under high shear stress: role of nitric oxide. Atherosclerosis\| PubMed ID: 14644391	2003
Bovine caveolin-2 cloning and effects of shear stress on its localization in bovine aortic endothelial cells. Endothelium : journal of endothelial cell research\| PubMed ID: 15370296	2004
Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxida... Circulation research\| PubMed ID: 15388638	2004
Simulated microgravity using the Random Positioning Machine inhibits differentiation and alters gene expression profiles of 2T3 preosteoblasts. American journal of physiology. Cell physiology\| PubMed ID: 15689415	2005
Transcriptional profiles of valvular and vascular endothelial cells reveal phenotypic differences: influence of shear stress. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 16293796	2006
Mechanical inhibition of RANKL expression is regulated by H-Ras-GTPase. The Journal of biological chemistry\| PubMed ID: 16306046	2006
Plasma membrane requirements for 1alpha,25(OH)2D3 dependent PKC signaling in chondrocytes and osteoblasts. Steroids\| PubMed ID: 16325216	2006
Caveolin-1 is transiently dephosphorylated by shear stress-activated protein tyrosine phosphatase mu. Biochemical and biophysical research communications\| PubMed ID: 16325778	2006
Laminar shear stress inhibits cathepsin L activity in endothelial cells. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 16709945	2006
Ascorbic acid synthesis due to L-gulono-1,4-lactone oxidase expression enhances NO production in endothelial cells. Biochemical and biophysical research communications\| PubMed ID: 16737683	2006
Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation. Circulation\| PubMed ID: 16769910	2006
Coordinated regulation of endothelial nitric oxide synthase activity by phosphorylation and subcellular localization. Free radical biology & medicine\| PubMed ID: 16781462	2006
Embryonic stem cell-derived endothelial cells may lack complete functional maturation in vitro. Journal of vascular research\| PubMed ID: 16877873	2006
Early determinants of H2O2-induced endothelial dysfunction. Free radical biology & medicine\| PubMed ID: 16895801	2006
Role of NADPH oxidases in disturbed flow- and BMP4- induced inflammation and atherosclerosis. Antioxidants & redox signaling\| PubMed ID: 16987015	2006
Regulation of growth plate chondrocytes by 1,25-dihydroxyvitamin D3 requires caveolae and caveolin-1. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 16995819	2006
An ex vivo study of the biological properties of porcine aortic valves in response to circumferential cyclic stretch. Annals of biomedical engineering\| PubMed ID: 17031600	2006
Cyclic pressure and shear stress regulate matrix metalloproteinases and cathepsin activity in porcine aortic valves. The Journal of heart valve disease\| PubMed ID: 17044366	2006
An improved method to measure nitrate/nitrite with an NO-selective electrochemical sensor. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society\| PubMed ID: 17056288	2007
Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosis. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17098827	2007
Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetes. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17237245	2007
Identification of mechanosensitive genes in osteoblasts by comparative microarray studies using the rotating wall vessel and the random positioning machine. Journal of cellular biochemistry\| PubMed ID: 17243119	2007
Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathway. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 17272757	2007
Reversible glutathiolation of caspase-3 by glutaredoxin as a novel redox signaling mechanism in tumor necrosis factor-alpha-induced cell death. Circulation research\| PubMed ID: 17272816	2007
Caveolin-1 knockout mice have increased bone size and stiffness. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 17550335	2007
Emerging role of IGF-1R in stretch-induced neointimal hyperplasia in venous grafts. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 17634521	2007
NFKB1 promoter variation implicates shear-induced NOS3 gene expression and endothelial function in prehypertensives and stage I hypertensives. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17644577	2007
Laminar shear inhibits tubule formation and migration of endothelial cells by an angiopoietin-2 dependent mechanism. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 17673702	2007
Bone morphogenic protein antagonists are coexpressed with bone morphogenic protein 4 in endothelial cells exposed to unstable flow in vitro in mouse aortas and in human coronary arteries: ro... Circulation\| PubMed ID: 17785623	2007
Laminar shear stress up-regulates peroxiredoxins (PRX) in endothelial cells: PRX 1 as a mechanosensitive antioxidant. The Journal of biological chemistry\| PubMed ID: 18024958	2008
Target accessibility and signal specificity in live-cell detection of BMP-4 mRNA using molecular beacons. Nucleic acids research\| PubMed ID: 18276638	2008
X-linked inhibitor of apoptosis protein is an important regulator of vascular endothelial growth factor-dependent bovine aortic endothelial cell survival. Circulation research\| PubMed ID: 18309102	2008
Design of an ex vivo culture system to investigate the effects of shear stress on cardiovascular tissue. Journal of biomechanical engineering\| PubMed ID: 18532871	2008
Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 18539760	2008
Angiopoietin-2 stimulates blood flow recovery after femoral artery occlusion by inducing inflammation and arteriogenesis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 18772493	2008
Laminar shear stress inhibits lipid peroxidation induced by high glucose plus arachidonic acid in endothelial cells. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 18790833	2008
Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-beta1-dependent pathway. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19023092	2009
Low magnitude and high frequency mechanical loading prevents decreased bone formation responses of 2T3 preosteoblasts. Journal of cellular biochemistry\| PubMed ID: 19125415	2009
Expression of CYP1A1 and CYP1B1 in human endothelial cells: regulation by fluid shear stress. Cardiovascular research\| PubMed ID: 19126602	2009
Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 19151254	2009
Redox-sensitive Akt and Src regulate coronary collateral growth in metabolic syndrome. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 19376806	2009
Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 19684185	2009
Systems analysis of the role of bone morphogenic protein 4 in endothelial inflammation. Annals of biomedical engineering\| PubMed ID: 19851868	2010
GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide. Circulation research\| PubMed ID: 19926872	2010
Intimal cushions and endothelial nuclear elongation around mouse aortic branches and their spatial correspondence with patterns of lipid deposition. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 19933414	2010
HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20351266	2010
Shear stress and plaque development. Expert review of cardiovascular therapy\| PubMed ID: 20397828	2010
X-linked inhibitor of apoptosis protein controls alpha5-integrin-mediated cell adhesion and migration. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 20472758	2010
Elevated cyclic stretch induces aortic valve calcification in a bone morphogenic protein-dependent manner. The American journal of pathology\| PubMed ID: 20489151	2010
Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow. Blood\| PubMed ID: 20551377	2010
Animal, in vitro, and ex vivo models of flow-dependent atherosclerosis: role of oxidative stress. Antioxidants & redox signaling\| PubMed ID: 20712399	2011
Endothelial metallothionein expression and intracellular free zinc levels are regulated by shear stress. American journal of physiology. Cell physiology\| PubMed ID: 20861469	2010
Detection of low levels of nitric oxide using an electrochemical sensor. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21161631	2011
Differences in valvular and vascular cell responses to strain in osteogenic media. Biomaterials\| PubMed ID: 21284997	2011
Angiotensin type I receptor blockade in conjunction with enhanced Akt activation restores coronary collateral growth in the metabolic syndrome. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 21335466	2011
The effects of combined cyclic stretch and pressure on the aortic valve interstitial cell phenotype. Annals of biomedical engineering\| PubMed ID: 21347552	2011
MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 21378144	2011
Redox going with vascular shear stress. Antioxidants & redox signaling\| PubMed ID: 21457103	2011
Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flow. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21512164	2011
Disturbed flow: p53 SUMOylation in the turnover of endothelial cells. The Journal of cell biology\| PubMed ID: 21624951	2011
Preferential activation of SMAD1/5/8 on the fibrosa endothelium in calcified human aortic valves--association with low BMP antagonists and SMAD6. PloS one\| PubMed ID: 21698246	2011
Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cells. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 21705672	2011
Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice. Circulation research\| PubMed ID: 21835911	2011
Serum BMP-4 levels in relation to arterial stiffness and carotid atherosclerosis in patients with Type 2 diabetes. Biomarkers in medicine\| PubMed ID: 22103619	2011
Dynamic Immune Cell Accumulation During Flow-Induced Atherogenesis in Mouse Carotid Artery: An Expanded Flow Cytometry Method. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 22247254	2012
Maturing EPCs into endothelial cells: may the force be with the EPCs: focus on "Fluid shear stress induces differentiation of circulating phenotype endothelial progenitor cells". American journal of physiology. Cell physiology\| PubMed ID: 22763124	2012
Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling. Biochemical and biophysical research communications\| PubMed ID: 22995306	2012
Aortic valve: mechanical environment and mechanobiology. Annals of biomedical engineering\| PubMed ID: 23515935	2013
The role of the vascular dendritic cell network in atherosclerosis. American journal of physiology. Cell physiology\| PubMed ID: 23552284	2013
Anti-inflammatory and antiatherogenic role of BMP receptor II in endothelial cells. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23559633	2013
Vascular injury involves the overoxidation of peroxiredoxin type II and is recovered by the peroxiredoxin activity mimetic that induces reendothelialization. Circulation\| PubMed ID: 23820076	2013
The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. Nature communications\| PubMed ID: 24346612	2013
Development of immortalized mouse aortic endothelial cell lines. Vascular cell\| PubMed ID: 24690145	2014
Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 24812324	2014
Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis. The Journal of clinical investigation\| PubMed ID: 24865430	2014
Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis: mechanosensitive athero-miRs. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25012134	2014
Disturbed flow enhances inflammatory signaling and atherogenesis by increasing thioredoxin-1 level in endothelial cell nuclei. PloS one\| PubMed ID: 25265386	2014
Fluid Mechanics, Arterial Disease, and Gene Expression. Annual review of fluid mechanics\| PubMed ID: 25360054	2014
The Role of Mechanical Stimulation in Recovery of Bone Loss-High versus Low Magnitude and Frequency of Force. Life (Basel, Switzerland)\| PubMed ID: 25370188	2014
Flow-Dependent Epigenetic DNA Methylation in Endothelial Gene Expression and Atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25953647	2015
Flow-dependent regulation of genome-wide mRNA and microRNA expression in endothelial cells in vivo. Scientific data\| PubMed ID: 25977794	2014
The role of epigenetics in the endothelial cell shear stress response and atherosclerosis. The international journal of biochemistry & cell biology\| PubMed ID: 25979369	2015
Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces. Circulation research\| PubMed ID: 26034042	2015
Micro-CT Technique Is Well Suited for Documentation of Remodeling Processes in Murine Carotid Arteries. PloS one\| PubMed ID: 26086218	2015
Vascular Proteomics Reveal Novel Proteins Involved in SMC Phenotypic Change: OLR1 as a SMC Receptor Regulating Proliferation and Inflammatory Response. PloS one\| PubMed ID: 26305474	2015
Multifunctional Nanoparticles Facilitate Molecular Targeting and miRNA Delivery to Inhibit Atherosclerosis in ApoE(-/-) Mice. ACS nano\| PubMed ID: 26308181	2015
The NADPH oxidase Nox4 has anti-atherosclerotic functions. European heart journal\| PubMed ID: 26385958	2015
The role of endothelial mechanosensitive genes in atherosclerosis and omics approaches. Archives of biochemistry and biophysics\| PubMed ID: 26686737	2016
Identification of side- and shear-dependent microRNAs regulating porcine aortic valve pathogenesis. Scientific reports\| PubMed ID: 27151744	2016
Discovery of novel peptides targeting pro-atherogenic endothelium in disturbed flow regions -Targeted siRNA delivery to pro-atherogenic endothelium in vivo. Scientific reports\| PubMed ID: 27173134	2016
Deep transcriptomic profiling reveals the similarity between endothelial cells cultured under static and oscillatory shear stress conditions. Physiological genomics\| PubMed ID: 27449656	2016
Simulated Microgravity and 3D Culture Enhance Induction, Viability, Proliferation and Differentiation of Cardiac Progenitors from Human Pluripotent Stem Cells. Scientific reports\| PubMed ID: 27492371	2016
Functional screening of mammalian mechanosensitive genes using Drosophila RNAi library- Smarcd3/Bap60 is a mechanosensitive pro-inflammatory gene. Scientific reports\| PubMed ID: 27819340	2016
Mechanosensitive microRNA-181b Regulates Aortic Valve Endothelial Matrix Degradation by Targeting TIMP3. Cardiovascular engineering and technology\| PubMed ID: 28236165	2018
KLF2 and KLF4 control endothelial identity and vascular integrity. JCI insight\| PubMed ID: 28239661	2017
Accelerated atherosclerosis development in C57Bl6 mice by overexpressing AAV-mediated PCSK9 and partial carotid ligation. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 28504688	2017
Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1. Circulation\| PubMed ID: 28778947	2017
Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 28882872	2017
Conserved Gene Microsynteny Unveils Functional Interaction Between Protein Disulfide Isomerase and Rho Guanine-Dissociation Inhibitor Families. Scientific reports\| PubMed ID: 29222525	2017
Vascular Semaphorin 7A Upregulation by Disturbed Flow Promotes Atherosclerosis Through Endothelial β1 Integrin. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 29269512	2018
3D Imaging and Quantitative Analysis of Vascular Networks: A Comparison of Ultramicroscopy and Micro-Computed Tomography. Theranostics\| PubMed ID: 29721067	2018
ZBTB46 is a shear-sensitive transcription factor inhibiting endothelial cell proliferation via gene expression regulation of cell cycle proteins. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 29884909	2019
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells. Nature communications\| PubMed ID: 29895827	2018
Role of flow-sensitive microRNAs and long noncoding RNAs in vascular dysfunction and atherosclerosis. Vascular pharmacology\| PubMed ID: 30300747	2019
Disturbed Flow Increases UBE2C (Ubiquitin E2 Ligase C) via Loss of miR-483-3p, Inducing Aortic Valve Calcification by the pVHL (von Hippel-Lindau Protein) and HIF-1α (Hypoxia-Inducible Facto... Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 30602302	2019
miR-214 is Stretch-Sensitive in Aortic Valve and Inhibits Aortic Valve Calcification. Annals of biomedical engineering\| PubMed ID: 30671754	2019
Conditional Deoxyribozyme-Nanoparticle Conjugates for miRNA-Triggered Gene Regulation. ACS applied materials & interfaces\| PubMed ID: 32803952	2020
Deletion of NoxO1 limits atherosclerosis development in female mice. Redox biology\| PubMed ID: 32949971	2020
Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis. Advanced drug delivery reviews\| PubMed ID: 33428994	2021
Delivery of Anti-microRNA-712 to Inflamed Endothelial Cells Using Poly(β-amino ester) Nanoparticles Conjugated with VCAM-1 Targeting Peptide. Advanced healthcare materials\| PubMed ID: 33448151	2021
Very late vasomotor responses and gene expression with bioresorbable scaffolds and metallic drug-eluting stents. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions\| PubMed ID: 34164905	2021
Combined LXR and RXR Agonist Therapy Increases ABCA1 Protein Expression and Enhances ApoAI-Mediated Cholesterol Efflux in Cultured Endothelial Cells. Metabolites\| PubMed ID: 34564456	2021