Albert Jeltsch

Institute of Biochemistry, Stuttgart University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 36	2014

Other Publications

Article	Year
DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution. PLoS genetics\| PubMed ID: 19325872	2009
Site-directed mutagenesis by polymerase chain reaction. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 11768980	2002
Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases. The Journal of biological chemistry\| PubMed ID: 11919202	2002
Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases. Chembiochem : a European journal of chemical biology\| PubMed ID: 11933228	2002
A fluorimetric assay for on-line detection of DNA cleavage by restriction endonucleases. Journal of biotechnology\| PubMed ID: 12039534	2002
The Escherichia coli dam DNA methyltransferase modifies DNA in a highly processive reaction. Journal of molecular biology\| PubMed ID: 12079349	2002
Specificity of DNA triple helix formation analyzed by a FRET assay. BMC biochemistry\| PubMed ID: 12323077	2002
Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA. European journal of biochemistry / FEBS\| PubMed ID: 12383256	2002
Probing the DNA interface of the EcoRV DNA-(adenine-N6)-methyltransferase by site-directed mutagenesis, fluorescence spectroscopy, and UV cross-linking. Biochemistry\| PubMed ID: 12450373	2002
High-throughput purification of polyHis-tagged recombinant fusion proteins. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 12491887	2003
Detection and analysis of enzymatic DNA methylation of oligonucleotide substrates by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Analytical biochemistry\| PubMed ID: 12576072	2003
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic acids research\| PubMed ID: 12654995	2003
Methylation sensitivity of restriction enzymes interacting with GATC sites. BioTechniques\| PubMed ID: 12765016	2003
Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme. Journal of molecular biology\| PubMed ID: 12787669	2003
The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity. The Journal of biological chemistry\| PubMed ID: 12794065	2003
Structural and biochemical characterization of a new Mg(2+) binding site near Tyr94 in the restriction endonuclease PvuII. Journal of molecular biology\| PubMed ID: 12888347	2003
Maintenance of species identity and controlling speciation of bacteria: a new function for restriction/modification systems? Gene\| PubMed ID: 14604787	2003
Chromatin targeting of de novo DNA methyltransferases by the PWWP domain. The Journal of biological chemistry\| PubMed ID: 14998998	2004
Stopped-flow and mutational analysis of base flipping by the Escherichia coli Dam DNA-(adenine-N6)-methyltransferase. Journal of molecular biology\| PubMed ID: 15276835	2004
The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites. The Journal of biological chemistry\| PubMed ID: 15339928	2004
Anomalous mobility of polymerase chain reaction products after bisulfite treatment of DNA. Analytical biochemistry\| PubMed ID: 15351297	2004
Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer biology & therapy\| PubMed ID: 15539938	2004
Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L. The Journal of biological chemistry\| PubMed ID: 15671018	2005
Profound flanking sequence preference of Dnmt3a and Dnmt3b mammalian DNA methyltransferases shape the human epigenome. Journal of molecular biology\| PubMed ID: 15854647	2005
Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase. Cell\| PubMed ID: 15882618	2005
Avidin plate assay system for enzymatic characterization of a histone lysine methyltransferase. Analytical biochemistry\| PubMed ID: 15935324	2005
De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases. Biochemistry\| PubMed ID: 16026162	2005
Developing a programmed restriction endonuclease for highly specific DNA cleavage. Nucleic acids research\| PubMed ID: 16356926	2005
Mutational analysis of the catalytic domain of the murine Dnmt3a DNA-(cytosine C5)-methyltransferase. Journal of molecular biology\| PubMed ID: 16472822	2006
Accuracy of DNA methylation pattern preservation by the Dnmt1 methyltransferase. Nucleic acids research\| PubMed ID: 16500889	2006
Structure and substrate recognition of the Escherichia coli DNA adenine methyltransferase. Journal of molecular biology\| PubMed ID: 16524590	2006
Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L. Human molecular genetics\| PubMed ID: 16543361	2006
Two substrates are better than one: dual specificities for Dnmt2 methyltransferases. Trends in biochemical sciences\| PubMed ID: 16679017	2006
German human methylome project started. Cancer research\| PubMed ID: 16849590	2006
Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes. Nucleic acids research\| PubMed ID: 17151075	2007
Reversible inactivation of the CG specific SssI DNA (cytosine-C5)-methyltransferase with a photocleavable protecting group. Chembiochem : a European journal of chemical biology\| PubMed ID: 17195251	2007
Application of DNA methyltransferases in targeted DNA methylation. Applied microbiology and biotechnology\| PubMed ID: 17431611	2007
Two alternative conformations of S-adenosyl-L-homocysteine bound to Escherichia coli DNA adenine methyltransferase and the implication of conformational changes in regulating the catalytic c... The Journal of biological chemistry\| PubMed ID: 17545164	2007
Deoxyribonucleic acid methyl transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene activation. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 17579209	2007
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature\| PubMed ID: 17713477	2007
Phosphorylation of serine-515 activates the Mammalian maintenance methyltransferase Dnmt1. Epigenetics : official journal of the DNA Methylation Society\| PubMed ID: 17965600	2007
On the enzymatic properties of Dnmt1: specificity, processivity, mechanism of linear diffusion and allosteric regulation of the enzyme. Epigenetics : official journal of the DNA Methylation Society\| PubMed ID: 17965604	2006
The M.EcoRV DNA-(adenine N6)-methyltransferase uses DNA bending for recognition of an expanded EcoDam recognition site. The Journal of biological chemistry\| PubMed ID: 17977824	2007
Continuous enzymatic assay for histone lysine methyltransferases. BioTechniques\| PubMed ID: 18072589	2007
Mapping of protein-protein interaction sites by the 'absence of interference' approach. Journal of molecular biology\| PubMed ID: 18191145	2008
Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays. Chemistry & biology\| PubMed ID: 18215768	2008
Detection and quantitation of the activity of DNA methyltransferases using a biotin/avidin microplate assay. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18287657	2008
Bisulfite sequencing Data Presentation and Compilation (BDPC) web server--a useful tool for DNA methylation analysis. Nucleic acids research\| PubMed ID: 18296484	2008
Cyclical DNA methylation of a transcriptionally active promoter. Nature\| PubMed ID: 18322525	2008
Persistent downregulation of the pancarcinoma-associated epithelial cell adhesion molecule via active intranuclear methylation. International journal of cancer. Journal international du cancer\| PubMed ID: 18398839	2008
Protein lysine methyltransferase G9a acts on non-histone targets. Nature chemical biology\| PubMed ID: 18438403	2008
Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism. RNA (New York, N.Y.)\| PubMed ID: 18567810	2008
Putting the pieces together: histone H2B ubiquitylation directly stimulates histone H3K79 methylation. Chembiochem : a European journal of chemical biology\| PubMed ID: 18712750	2008
Reading and writing DNA methylation. Nature structural & molecular biology\| PubMed ID: 18836494	2008
Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. Nucleic acids research\| PubMed ID: 18945701	2008
DNA methylation analysis by bisulfite conversion, cloning, and sequencing of individual clones. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18987815	2009
Impact of 7,8-dihydro-8-oxoguanine on methylation of the CpG site by Dnmt3a. Biochemistry\| PubMed ID: 19161295	2009
Specificity of protein lysine methyltransferases and methods for detection of lysine methylation of non-histone proteins. Molecular bioSystems\| PubMed ID: 19396382	2008
The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding. Proteins\| PubMed ID: 19434754	2009
On the divalent metal ion dependence of DNA cleavage by restriction endonucleases of the EcoRI family. Journal of molecular biology\| PubMed ID: 19682999	2009
Transition from EcoDam to T4Dam DNA recognition mechanism without loss of activity and specificity. Chembiochem : a European journal of chemical biology\| PubMed ID: 19725089	2009
A continuous protein methyltransferase (G9a) assay for enzyme activity measurement and inhibitor screening. Journal of biomolecular screening\| PubMed ID: 19734436	2009
Changing the DNA recognition specificity of the EcoDam DNA-(adenine-N6)-methyltransferase by directed evolution. Journal of molecular biology\| PubMed ID: 19766657	2010
New clustering module in BDPC bisulfite sequencing data presentation and compilation web application for DNA methylation analyses. BioTechniques\| PubMed ID: 19852764	2009
Non-imprinted allele-specific DNA methylation on human autosomes. Genome biology\| PubMed ID: 19958531	2009
Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail. Nucleic acids research\| PubMed ID: 20223770	2010
BISMA--fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences. BMC bioinformatics\| PubMed ID: 20459626	2010
Molecular biology. Phylogeny of methylomes. Science (New York, N.Y.)\| PubMed ID: 20466912	2010
The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation. The Journal of biological chemistry\| PubMed ID: 20547484	2010
Silencing of gene expression by targeted DNA methylation: concepts and approaches. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20680833	2010
Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine. PloS one\| PubMed ID: 20808780	2010
Detailed specificity analysis of antibodies binding to modified histone tails with peptide arrays. Epigenetics : official journal of the DNA Methylation Society\| PubMed ID: 20962581	2011
Molecular epigenetics: connecting human biology and disease with little marks. Chembiochem : a European journal of chemical biology\| PubMed ID: 21243707	2011
Structure and function of mammalian DNA methyltransferases. Chembiochem : a European journal of chemical biology\| PubMed ID: 21243710	2011
Specificity analysis-based identification of new methylation targets of the SET7/9 protein lysine methyltransferase. Chemistry & biology\| PubMed ID: 21276944	2011
Approaches to enzyme and substrate design of the murine Dnmt3a DNA methyltransferase. Chembiochem : a European journal of chemical biology\| PubMed ID: 21400651	2011
The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9. Human molecular genetics\| PubMed ID: 21421568	2011
Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue. The FEBS journal\| PubMed ID: 21481189	2011
The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols. BMC biochemistry\| PubMed ID: 21510884	2011
Oligomerization and binding of the Dnmt3a DNA methyltransferase to parallel DNA molecules: heterochromatic localization and role of Dnmt3L. The Journal of biological chemistry\| PubMed ID: 21566127	2011
Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase. Cell research\| PubMed ID: 21606950	2011
C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development. Chembiochem : a European journal of chemical biology\| PubMed ID: 21633996	2011
Application of Celluspots peptide arrays for the analysis of the binding specificity of epigenetic reading domains to modified histone tails. BMC biochemistry\| PubMed ID: 21884582	2011
DNA methyltransferase assays. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21913079	2011
The Caulobacter crescentus DNA-(adenine-N6)-methyltransferase CcrM methylates DNA in a distributive manner. Nucleic acids research\| PubMed ID: 21926159	2012
Function and disruption of DNA methyltransferase 3a cooperative DNA binding and nucleoprotein filament formation. Nucleic acids research\| PubMed ID: 21926161	2012
Using the fluorescence decay of 2-aminopurine to investigate conformational change in the recognition sequence of the EcoRV DNA-(adenine-N6)-methyltransferase on enzyme binding. Biophysical chemistry\| PubMed ID: 21962489	2012
Burning off DNA methylation: new evidence for oxygen-dependent DNA demethylation. Chembiochem : a European journal of chemical biology\| PubMed ID: 21998074	2011
Epigenetics Europe conference. Munich, Germany, 8-9 September 2011. Epigenomics\| PubMed ID: 22126289	2011
On the evolutionary origin of eukaryotic DNA methyltransferases and Dnmt2. PloS one\| PubMed ID: 22140515	2011
Rapid synthesis of new DNMT inhibitors derivatives of procainamide. Chembiochem : a European journal of chemical biology\| PubMed ID: 22170584	2012
A fluorescence-based supramolecular tandem assay for monitoring lysine methyltransferase activity in homogeneous solution. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 22367964	2012
The SET8 H4K20 protein lysine methyltransferase has a long recognition sequence covering seven amino acid residues. Biochimie\| PubMed ID: 22583696	2012
Mapping the tRNA binding site on the surface of human DNMT2 methyltransferase. Biochemistry\| PubMed ID: 22591353	2012
Specificity of Dnmt1 for methylation of hemimethylated CpG sites resides in its catalytic domain. Chemistry & biology\| PubMed ID: 22633409	2012
DNA interaction of the CcrM DNA methyltransferase: a mutational and modeling study. Chembiochem : a European journal of chemical biology\| PubMed ID: 22639453	2012
Mechanistic details of the DNA recognition by the Dnmt1 DNA methyltransferase. FEBS letters\| PubMed ID: 22641038	2012
Identification of ICAD-derived peptides capable of inhibiting caspase-activated DNase. The FEBS journal\| PubMed ID: 22727028	2012
DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies. Expert opinion on therapeutic patents\| PubMed ID: 23033952	2012
Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling. Nucleic acids research\| PubMed ID: 23074192	2012
Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a-Dnmt3L single-chain fusion protein with increased DNA methylation activity. Journal of molecular biology\| PubMed ID: 23220192	2013
Identification of novel inhibitors of DNA methylation by screening of a chemical library. ACS chemical biology\| PubMed ID: 23294304	2013
Oxygen, epigenetic signaling, and the evolution of early life. Trends in biochemical sciences\| PubMed ID: 23454078	2013
Multimerization of the dnmt3a DNA methyltransferase and its functional implications. Progress in molecular biology and translational science\| PubMed ID: 23663978	2013
Non-radioactive protein lysine methyltransferase microplate assay based on reading domains. ChemMedChem\| PubMed ID: 23671032	2014
Target recognition, RNA methylation activity and transcriptional regulation of the Dictyostelium discoideum Dnmt2-homologue (DnmA). Nucleic acids research\| PubMed ID: 23877245	2013
The Tudor domain of the PHD finger protein 1 is a dual reader of lysine trimethylation at lysine 36 of histone H3 and lysine 27 of histone variant H3t. Journal of molecular biology\| PubMed ID: 23954330	2014
Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1. Journal of medicinal chemistry\| PubMed ID: 24328113	2014
Genomic imprinting--the struggle of the genders at the molecular level. Angewandte Chemie (International ed. in English)\| PubMed ID: 24346936	2013
The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism. The Journal of biological chemistry\| PubMed ID: 24368767	2014
Substrate specificity analysis and novel substrates of the protein lysine methyltransferase NSD1. Chemistry & biology\| PubMed ID: 24412544	2014
Targeted methylation of the epithelial cell adhesion molecule (EpCAM) promoter to silence its expression in ovarian cancer cells. PloS one\| PubMed ID: 24489952	2014
Targeted mutagenesis results in an activation of DNA methyltransferase 1 and confirms an autoinhibitory role of its RFTS domain. Chembiochem : a European journal of chemical biology\| PubMed ID: 24532244	2014
Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation. ChemMedChem\| PubMed ID: 24678024	2014
The application of next generation sequencing in DNA methylation analysis. Genes\| PubMed ID: 24710012	2010
The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu. Nucleic acids research\| PubMed ID: 24711368	2014
Label-free measurement of histone lysine methyltransferases activity by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Analytical biochemistry\| PubMed ID: 24747023	2014
New concepts in DNA methylation. Trends in biochemical sciences\| PubMed ID: 24947342	2014
Regulation of DNA methylation patterns by CK2-mediated phosphorylation of Dnmt3a. Cell reports\| PubMed ID: 25066127	2014
Role of somatic cancer mutations in human protein lysine methyltransferases. Biochimica et biophysica acta\| PubMed ID: 25123655	2014
Cooperative DNA Binding and Protein/DNA Fiber Formation Increases the Activity of the Dnmt3a DNA Methyltransferase. The Journal of biological chemistry\| PubMed ID: 25147181	2014
Application of histone modification-specific interaction domains as an alternative to antibodies. Genome research\| PubMed ID: 25301795	2014